大果飞蛾藤的研究现状和展望
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摘要
随着正品丁公藤药材野生资源的减少,大果飞蛾藤已成为其主流替代品。通过查阅国内外相关文献及专利,对大果飞蛾藤化学成分、药理作用及其作为丁公藤的代用品的研究进行总结,为大果飞蛾藤的深入开发和利用提供参考依据。目前从大果飞蛾藤中分离分析共发现15个化合物,包括香豆素、酚酸、酰胺、苯醌及甾类成分。大果飞蛾藤及其有效成分具有抗痛风、抗炎镇痛、抗肿瘤、保护心脑血管、抗糖尿病、抗微生物、抗氧化、杀农业病原虫等作用。同时,对大果飞蛾藤作为丁公藤药材代用品的研究利用进行了总结和展望。
Porana sinensis has become a widely used substitute for Erycibes Caulis with the reduction of Erycibes Caulis resources in the wild. Chemical components, pharmacological effects and a substitute for Erycibes Caulis of Porana sinensis are summarized by referring to relevant domestic and foreign literatures and patents,so as to provide some useful and basic suggestions of Porana sinensis for the future. It shows that 15 compounds have been found from Porana sinensis, including coumarins, phenolic acids, amides, benzoquinones and steroids.Porana sinensis and its active ingredients have anti-gout, anti-inflammatory, analgesic, anti-tumor, protection on cardiac cerebral vessel, antidiabetic, antimicrobial, antioxidant, insecticidal and other pharmacological effects.Simultaneously, a conclusion and prospect on the research and utilization of Porana sinensis used as a substitute for Erycibes Caulis in the future is made.
Porana sinensis has become a widely used substitute for Erycibes Caulis with the reduction of Erycibes Caulis resources in the wild. Chemical components, pharmacological effects and a substitute for Erycibes Caulis of Porana sinensis are summarized by referring to relevant domestic and foreign literatures and patents,so as to provide some useful and basic suggestions of Porana sinensis for the future. It shows that 15 compounds have been found from Porana sinensis, including coumarins, phenolic acids, amides, benzoquinones and steroids.Porana sinensis and its active ingredients have anti-gout, anti-inflammatory, analgesic, anti-tumor, protection on cardiac cerebral vessel, antidiabetic, antimicrobial, antioxidant, insecticidal and other pharmacological effects.Simultaneously, a conclusion and prospect on the research and utilization of Porana sinensis used as a substitute for Erycibes Caulis in the future is made.
引文
[1]张朝凤,张紫佳,张勉,等.大果飞蛾藤的化学成分研究[J].中国药学杂志,2006,41(2):94-96.
[2]国家药典委员会.中华人民共和国药典(一部)[S].北京:中国医药科技出版社,2015:3-4.
[3]吴立宏,朱恩圆,张紫佳,等.广西产丁公藤原植物的调查及商品丁公藤主流品种鉴定[J].中草药,2005,36(9):1398-1401.
[4]Chen Z Y,Liao L P,Yang Y Y,et al.Different fingerprinting strategies to differentiate Porana sinensis and plants of Erycibe by high-performance liquid chromatography with diode array detection,ultra high performance liquid chromatography with tandem quadrupole mass spectrometry,and chemometrics[J].J Sep Sci,2015,38(2):231-238.
[5]Chen Z Y,Tao H X,Liao L P,et al.Quick identification of xanthine oxidase inhibitor and antioxidant from Erycibe obtusifolia by a drug discovery platform composed of multiple mass spectrometric platforms and thin-layer chromatography bioautography[J].J Sep Sci,2014,37(16):2253-2259.
[6]Xia Y F,Dai Y,Wang Q,et al.Determination of scopoletin in rat plasma by high performance liquid chromatographic method with UV detection andits application to a pharmacokineticstudy[J].J Chromatogr B,2007,857:332-336.
[7]戴岳,王铮涛,丁佐奇.东莨菪素在制备防治高尿酸血症药物中的应用[P].中国,200410065021,2005-05-18.
[8]Pan R,Gao X H,Li Y,et al.Anti-arthritic effect of scopoletin,a coumarin compound occurring in Erycibe obtusifolia Benth stems is associated with decreased angiogenesis in synovium[J].Fundam Clin Pharmacol,2010,24(4):477-490.
[9]Chen Z Y,Liao L P,Zhang Z J,et al.Comparison of active constituents,acute toxicity,anti-nociceptive and anti-inflammatory activities of Porana sinensis Hemsl.,Erycibe obtusifolia Benth.and Erycibe schmidtii Craib[J].J Ethnopharmacol,2013,150(2):501-506.
[10]Xue Q,Fan H,Li K,et al.Comparative evaluations on phenolic antioxidants of nine adulterants and anti-inflammation of four alternatives with their original herb Erycibe schmidtii[J].RSC Adv,2017,7:51151-51161.
[11]肖志彬,贾韩学,刘小雷.β-谷甾醇药理活性的研究现状[J].世界最新医学信息文摘,2015,15(8):66-68.
[12]李斌,陈钰妍,李顺祥.飞蛾藤属植物化学成分和药理作用研究进展[J].科技导报,2013,31(11):74-79.
[13]Moon P D,Lee B H,Jeong H J,et al.Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the I kappa B/NF-kappa B signal cascade in the human mast cell line HMC-1[J].Eur JPharmacol,2007,555:218-225.
[14]赵昱,赵军,李湘萍,等.咖啡酰奎尼酸类化合物研究进展[J].中国中药杂志,2006,31(11):869-874.
[15]Kurdekar R R,Hegde1 G R,Kulkarni M V,et al.Isolation and characterization of scopoletin-an anticancer compound from the bark of Hymenodictyon obovatum Wall[J].J Pharm Phytopharmacol Res,2014,3(6):469-471.
[16]Darmawan A,Kosela S,Kardono L,et al.Scopoletin,a coumarin derivative compound isolated from Macaranga gigantifolia Merr[J].J Appl Pharm Sci,2012,2(12):175-177.
[17]Li C L,Han X C,Zhang H,et al.Effect of scopoletin on apoptosis and cell cycle arrest in human prostate cancer cells in vitro[J].Trop J Pharm Res,2015,14(4):611-617.
[18]Maria G M,Graciela F,Maria B A,et al.Comparative immunomodulatory effect of scopoletin on tumoral and normal lymphocytes[J].Life Sci,2006,79(21):2043-2048.
[19]Seo E J,Saeed M,Law B Y K,et al.Pharmacogenomics of scopoletin in tumor cells[J].Molecules,2016,21(4):496-518.
[20]韩枫.东莨菪内酯的药理活性和药动学研究进展[J].中国药房,2011,22(31):2971-2972.
[21]Tabana Y M,Hassan L E A,Ahamed M B K,et al.Scopoletin,an active principle of tree tobacco(Nicotiana glauca)inhibits human tumor vascularization in xenograft models and modulates ERK1,VEGF-A,and FGF-2 in computer model[J],Microvasc Res,2016,107:17-33.
[22]赵秀红.β-谷甾醇对肝癌HepG2细胞增殖和凋亡的影响及机制研究[D].兰州:兰州大学,2018.
[23]盛艳梅,唐绍微,张静,等.3,5-二咖啡酰奎宁酸体外透血脑屏障能力及抗大鼠脑缺血再灌注损伤作用研究[J].中药药理与临床,2016,32(6):26-29.
[24]那袭雪,张文涛,谈远锋,等.绿原酸及其异构体药理作用及不良反应研究进展[J].辽宁中医药大学学报,2018,20(3):140-144.
[25]韩红英,李国玉,王航宇,等.全裂叶阿魏中拉迪替醇和东莨菪素抗凝血活性的研究[J].农垦医学,2010(2):112-114.
[26]Ong K W,Hsu A,Tan B K H.Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation[J].Biochem Pharmaco,2013,85(9):1341-1351.
[27]Ma Y J,Gao M M,Liu D X.Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice[J].Pharm Res,2015,32(4):1200-1209.
[28]夏超,李满妹,李药兰,等.天然咖啡酰基奎宁酸类化合物抗RSV活性及其构效关系研究[J].中药材,2016,39(2):383-388.
[29]夏玉玲,徐立,张占营,等.桑树东莨菪素体外抗假丝酵母菌活性初步研究[J].吉林农业,2011,261(11):75-76.
[30]刘微微,任虹,曹学丽,等.天然产物抗氧化活性体外评价方法研究进展[J].食品科学,2010,31(17):415-419.
[31]吴吉,喻叶楠,张心怡,等.3,5-O-二咖啡酰基奎宁酸的稳定性和抗氧化活性研究[J].中国现代应用药学,2017,34(10):1397-1400.
[32]祝茗,张开梅,丁燕.茵陈蒿中滨蒿內酯及东莨菪素抗氧化活性的评价[J].沈阳药科大学学报,2016,33(11):889-893.
[33]Nam H,Kim M M.Scopoletin has a potential activity for anti-aging via autophagy in human lung fibroblasts[J].Phytomedicine,2015,22(3):362-368.
[34]Gnonlonfin G J B,Sanni A,Brimer L.Review scopoletin-a coumarin phytoalexin with medicinal properties[J].Crit Rev Plant Sci,2012,31(1):47-56.
[35]张紫佳,张勉,朱恩圆,等.丁公藤类药材及其混用品中总东莨菪内酯的含量测定[J].中国药学杂志,2004,39(12):936-938.
[36]杨媛媛,张鑫,张楠,等.大果飞蛾藤质量标准研究[J].中药材,2018,41(7):1657-1662.
[2]国家药典委员会.中华人民共和国药典(一部)[S].北京:中国医药科技出版社,2015:3-4.
[3]吴立宏,朱恩圆,张紫佳,等.广西产丁公藤原植物的调查及商品丁公藤主流品种鉴定[J].中草药,2005,36(9):1398-1401.
[4]Chen Z Y,Liao L P,Yang Y Y,et al.Different fingerprinting strategies to differentiate Porana sinensis and plants of Erycibe by high-performance liquid chromatography with diode array detection,ultra high performance liquid chromatography with tandem quadrupole mass spectrometry,and chemometrics[J].J Sep Sci,2015,38(2):231-238.
[5]Chen Z Y,Tao H X,Liao L P,et al.Quick identification of xanthine oxidase inhibitor and antioxidant from Erycibe obtusifolia by a drug discovery platform composed of multiple mass spectrometric platforms and thin-layer chromatography bioautography[J].J Sep Sci,2014,37(16):2253-2259.
[6]Xia Y F,Dai Y,Wang Q,et al.Determination of scopoletin in rat plasma by high performance liquid chromatographic method with UV detection andits application to a pharmacokineticstudy[J].J Chromatogr B,2007,857:332-336.
[7]戴岳,王铮涛,丁佐奇.东莨菪素在制备防治高尿酸血症药物中的应用[P].中国,200410065021,2005-05-18.
[8]Pan R,Gao X H,Li Y,et al.Anti-arthritic effect of scopoletin,a coumarin compound occurring in Erycibe obtusifolia Benth stems is associated with decreased angiogenesis in synovium[J].Fundam Clin Pharmacol,2010,24(4):477-490.
[9]Chen Z Y,Liao L P,Zhang Z J,et al.Comparison of active constituents,acute toxicity,anti-nociceptive and anti-inflammatory activities of Porana sinensis Hemsl.,Erycibe obtusifolia Benth.and Erycibe schmidtii Craib[J].J Ethnopharmacol,2013,150(2):501-506.
[10]Xue Q,Fan H,Li K,et al.Comparative evaluations on phenolic antioxidants of nine adulterants and anti-inflammation of four alternatives with their original herb Erycibe schmidtii[J].RSC Adv,2017,7:51151-51161.
[11]肖志彬,贾韩学,刘小雷.β-谷甾醇药理活性的研究现状[J].世界最新医学信息文摘,2015,15(8):66-68.
[12]李斌,陈钰妍,李顺祥.飞蛾藤属植物化学成分和药理作用研究进展[J].科技导报,2013,31(11):74-79.
[13]Moon P D,Lee B H,Jeong H J,et al.Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the I kappa B/NF-kappa B signal cascade in the human mast cell line HMC-1[J].Eur JPharmacol,2007,555:218-225.
[14]赵昱,赵军,李湘萍,等.咖啡酰奎尼酸类化合物研究进展[J].中国中药杂志,2006,31(11):869-874.
[15]Kurdekar R R,Hegde1 G R,Kulkarni M V,et al.Isolation and characterization of scopoletin-an anticancer compound from the bark of Hymenodictyon obovatum Wall[J].J Pharm Phytopharmacol Res,2014,3(6):469-471.
[16]Darmawan A,Kosela S,Kardono L,et al.Scopoletin,a coumarin derivative compound isolated from Macaranga gigantifolia Merr[J].J Appl Pharm Sci,2012,2(12):175-177.
[17]Li C L,Han X C,Zhang H,et al.Effect of scopoletin on apoptosis and cell cycle arrest in human prostate cancer cells in vitro[J].Trop J Pharm Res,2015,14(4):611-617.
[18]Maria G M,Graciela F,Maria B A,et al.Comparative immunomodulatory effect of scopoletin on tumoral and normal lymphocytes[J].Life Sci,2006,79(21):2043-2048.
[19]Seo E J,Saeed M,Law B Y K,et al.Pharmacogenomics of scopoletin in tumor cells[J].Molecules,2016,21(4):496-518.
[20]韩枫.东莨菪内酯的药理活性和药动学研究进展[J].中国药房,2011,22(31):2971-2972.
[21]Tabana Y M,Hassan L E A,Ahamed M B K,et al.Scopoletin,an active principle of tree tobacco(Nicotiana glauca)inhibits human tumor vascularization in xenograft models and modulates ERK1,VEGF-A,and FGF-2 in computer model[J],Microvasc Res,2016,107:17-33.
[22]赵秀红.β-谷甾醇对肝癌HepG2细胞增殖和凋亡的影响及机制研究[D].兰州:兰州大学,2018.
[23]盛艳梅,唐绍微,张静,等.3,5-二咖啡酰奎宁酸体外透血脑屏障能力及抗大鼠脑缺血再灌注损伤作用研究[J].中药药理与临床,2016,32(6):26-29.
[24]那袭雪,张文涛,谈远锋,等.绿原酸及其异构体药理作用及不良反应研究进展[J].辽宁中医药大学学报,2018,20(3):140-144.
[25]韩红英,李国玉,王航宇,等.全裂叶阿魏中拉迪替醇和东莨菪素抗凝血活性的研究[J].农垦医学,2010(2):112-114.
[26]Ong K W,Hsu A,Tan B K H.Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation[J].Biochem Pharmaco,2013,85(9):1341-1351.
[27]Ma Y J,Gao M M,Liu D X.Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice[J].Pharm Res,2015,32(4):1200-1209.
[28]夏超,李满妹,李药兰,等.天然咖啡酰基奎宁酸类化合物抗RSV活性及其构效关系研究[J].中药材,2016,39(2):383-388.
[29]夏玉玲,徐立,张占营,等.桑树东莨菪素体外抗假丝酵母菌活性初步研究[J].吉林农业,2011,261(11):75-76.
[30]刘微微,任虹,曹学丽,等.天然产物抗氧化活性体外评价方法研究进展[J].食品科学,2010,31(17):415-419.
[31]吴吉,喻叶楠,张心怡,等.3,5-O-二咖啡酰基奎宁酸的稳定性和抗氧化活性研究[J].中国现代应用药学,2017,34(10):1397-1400.
[32]祝茗,张开梅,丁燕.茵陈蒿中滨蒿內酯及东莨菪素抗氧化活性的评价[J].沈阳药科大学学报,2016,33(11):889-893.
[33]Nam H,Kim M M.Scopoletin has a potential activity for anti-aging via autophagy in human lung fibroblasts[J].Phytomedicine,2015,22(3):362-368.
[34]Gnonlonfin G J B,Sanni A,Brimer L.Review scopoletin-a coumarin phytoalexin with medicinal properties[J].Crit Rev Plant Sci,2012,31(1):47-56.
[35]张紫佳,张勉,朱恩圆,等.丁公藤类药材及其混用品中总东莨菪内酯的含量测定[J].中国药学杂志,2004,39(12):936-938.
[36]杨媛媛,张鑫,张楠,等.大果飞蛾藤质量标准研究[J].中药材,2018,41(7):1657-1662.
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