IGF-1/IGF-1R信号通路在皮肤光损伤中的研究进展
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摘要
胰岛素样生长因子(IGFs)通过与细胞表面的胰岛素样生长因子受体结合,激活一系列下游信号通路,发挥促进细胞增殖、分化和抑制凋亡等作用。近年来研究发现,胰岛素样生长因子-1/胰岛素样生长因子1受体(IGF-1/IGF-1R)信号通路在皮肤成纤维细胞中可以促进胶原蛋白的合成,同时能抑制紫外线(UV)诱导的皮肤角质形成细胞癌变。因此,IGF-1/IGF-1R信号通路在UV照射引起的一系列皮肤损伤,如光老化及皮肤良性肿瘤,甚至是各种皮肤癌的发生中均发挥着重要作用。该文就IGF-1/IGF-1R信号通路在抗皮肤光老化及UV诱导皮肤肿瘤中的作用和相关机制作一综述。
引文
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[2]Hartog H,Wesseling J,Boezen HM,et al.The insulin-like growth factor 1 receptor in cancer:old focus,new future[J].Eur J Cancer,2007,43(13):1895-1904.
[3]Lewis DA,Travers JB,Somani AK,et al.The IGF-1/IGF-1Rsignaling axis in the skin:a new role for the dermis in agingassociated skin cancer[J].Oncogene,2010,29(10):1475-1485.
[4]Poon F,Kang S,Chien AL.Mechanisms and treatments of photoaging[J].Photodermatol Photoimmunol Photomed,2015,31(2):65-74.
[5]Shim JH,Shin DW,Lee TR,et al.The retinoic acid-induced up-regulation of insulin-like growth factor 1 and 2 is associated with prolidase-dependent collagen synthesis in UVA-irradiated human dermal equivalents[J].J Dermatol Sci,2012,66(1):51-59.
[6]Brandt K,Grunler J,Brismar K,et al.Effects of IGFBP-1 and IGFBP-2 and their fragments on migration and IGF-induced proliferation of human dermal fibroblasts[J].Growth Horm IGF Res,2015,25(1):34-40.
[7]Hakuno F,Takahashi SI.IGF1 receptor signaling pathways[J].JMol Endocrinol,2018,61(1):T69-T86.
[8]Takasao N,Tsuji-Naito K,Ishikura S,et al.Cinnamon extract promotes typeⅠcollagen biosynthesis via activation of IGF-Ⅰsignaling in human dermal fibroblasts[J].J Agric Food Chem,2012,60(5):1193-1200.
[9]Szoka L,Karna E,Hlebowicz-Sarat K,et al.Exogenous proline stimulates typeⅠcollagen and HIF-1alpha expression and the process is attenuated by glutamine in human skin fibroblasts[J].Mol Cell Biochem,2017,435(1-2):197-206.
[10]Zareba I,Palka J.Prolidase-proline dehydrogenase/proline oxidase-collagen biosynthesis axis as a potential interface of apoptosis/autophagy[J].Biofactors,2016,42(4):341-348.
[11]Szoka L,Karna E,Morka RP,et al.Enalapril stimulates collagen biosynthesis through prolidase-dependent mechanism in cultured fibroblasts[J].Naunyn Schmiedebergs Arch Pharmacol,2015,388(6):677-683.
[12]Fang Y,Hu XH,Jia ZG,et al.Tiron protects against UVB-induced senescence-like characteristics in human dermal fibroblasts by the inhibition of superoxide anion production and glutathione depletion[J].Australas J Dermatol,2012,53(3):172-180.
[13]Kemp MG,Spandau DF,Travers JB.Impact of age and insulinlike growth factor-1 on DNA damage responses in UV-irradiated human skin[J].Molecules,2017,22(3):pii:E356.
[14]Gegotek A,Bielawska K,Biernacki M,et al.Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide[J].Arch Dermatol Res,2017,309(4):285-303.
[15]Lewis DA,Travers JB,Machado C,et al.Reversing the aging stromal phenotype prevents carcinoma initiation[J].Aging(Albany NY),2011,3(4):407-416.
[16]Spandau DF,Lewis DA,Somani AK,et al.Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin[J].J Invest Dermatol,2012,132(6):1591-1596.
[17]Baek M,Kim M,Lim JS,et al.Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling[J].Cell Death Dis,2018,9(7):730.
[18]Khan AQ,Travers JB,Kemp MG.Roles of UVA radiation and DNA damage responses in melanoma pathogenesis[J].Environ Mol Mutagen,2018,59(5):438-460.
[19]Lewis DA,Travers JB,Spandau DF.A new paradigm for the role of aging in the development of skin cancer[J].J Invest Dermatol,2009,129(3):787-791.
[20]Kemp MG,Spandau DF,Simman R,et al.Insulin-like growth factor 1 receptor signaling is required for optimal ATR-Chk1kinase signaling in ultraviolet B(UVB)-irradiated human keratinocytes[J].J Biol Chem,2017,292(4):1231-1239.
[21]Loesch MM,Collier AE,Southern DH,et al.Insulin-like growth factor-1 receptor regulates repair of ultraviolet B-induced DNAdamage in human keratinocytes in vivo[J].Mol Oncol,2016,10(8):1245-1254.
[22]Smits VA,Gillespie DA.DNA damage control:regulation and functions of checkpoint kinase 1[J].FEBS J,2015,282(19):3681-3692.
[23]Fernandez TL,Van Lonkhuyzen DR,Dawson RA,et al.Insulinlike growth factor-I and UVB photoprotection in human keratinocytes[J].Exp Dermatol,2015,24(3):235-238.