肝移植术后高尿酸血症的相关危险因素研究进展
摘要
高尿酸血症(HUA)是肝移植术后的常见代谢并发症。尿酸是嘌呤代谢的终产物,而肝脏是体内嘌呤氧化代谢生成尿酸的主要器官。器官移植术后血尿酸升高可增加代谢综合征、动脉粥样硬化、移植物失功等并发症的发生率。肝移植术后发生HUA的主要危险因素与免疫抑制剂的应用及代谢综合征的发生密切相关。HUA严重影响肝移植病人生活质量和预后,因此HUA的早期诊断、早期治疗对于肝移植受者术后并发症的预防和长期存活具有重要意义。
引文
[1]NEAL D A,TOM B D,GIMSON A E,et al.Hyperuricemia,gout,and renal function after liver transplantation[J].Transplantation,2001,72(10):1689-1691.
[2]饶伟萍,牛玉坚,王宏宇,等.肝移植术后高尿酸血症的发生率和相关危险因素分析:单中心回顾性研究[J].中华内分泌外科杂志,2015,9(6):493-496.
[3]MUREA M.Advanced kidney failure and hyperuricemia[J].Adv Chronic Kidney Dis,2012,19(6):419-424.
[4]SIMAO A N,LOZOVOY M A,DICHI I.The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome[J].EXPERT Opin Ther Targets,2012,16(12):1175-1187.
[5]葛均波,徐永健.内科学[M].8版.北京:人民卫生出版社,2014:792.
[6]LISA S,MARTIN S,JOHN O,et al.Gout in solid organ transplantation:A challenging clinical problem[J].Drugs,2005,65(18):2593-2611.
[7]KRISHNAN E,PANDYA B J,CHUNG L,et al.Hyperuricemia and the risk for subclinical coronary atherosclerosis-data from a prospective observational cohort study[J].Arthritis Res Ther,2011,13(2):R66.
[8]RUGGIERO C,CHERUBINI A,BLE A,et al.Uric acid and inflammatory markers[J].Eur Heart J,2006,27(10):1174-1181.
[9]ELSAYED A S,MOSTAFA M M,ABDELKHALIK A,et al.Hyperuricemia and its association with carotid intimamedia thickness in hypertensive and non hypertensive patients[J].J Saudi Heart Assoc,2010,22(1):19-23.
[10]MAZZALI M,HUGHES J,KIM Y G,et al.Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism[J].Hypertension,2001,38(5):1101-1106.
[11]KIM K M,KIM S S,YUN S,et al.Uric acid contributes to glomerular filtration rate deterioration in renal transplantation[J].Nephron Clin Prac,2011,118(2):c136-142.
[12]ERKMEN UYAR M,SEZER S,BAL Z,et al.Post-transplant hyperuricemia as a cardiovascular risk factor[J].Transplant Proc,2015,47(4):1146-1151.
[13]HUANG Y,LI Y L,HUANG H.Effects of hyperuricemia on renal function of renal transplant recepients:A systematic review and meta-analysis of cohort studies[J].PLoS One,2012,7(6):e39457.
[14]AKGUL A,BILGIC A,IBIS A,et al.Is uric acid a predictive factor for graft dysfunction in renal transplant recipients[J]?Transplant Proc,2007,39(4):1023-1026.
[15]HARIRIAN A,NOGUEIRA J M,ZANDI-NEJAD K,et al.The independent association between serum uric acid and graft outcomes after kidney transplantation[J].Transplantation,2010,89(5):573-579.
[16]HARAMBAT J,DUBOURG L,RANCHIN B,et al.Hyperuricemia after liver transplantation in children[J].Pediatr Transplant,2008,12(8):847-53.
[17]LONGENECKER J C,WAHEED S,BANDAK G,et al.Hyperuricemia after orthotopic liver transplantation:Divergent associations with progression of renal disease,incident endstage renal disease,and mortality[J].BMC Nephrol,2017,27;18(1):103.
[18]LU H Y,NING X Y,CHEN Y Q,et al.Predictive value of serum creatinine,blood urea nitrogen,uric acid,andβ2-microglobulin in the evaluation of acute kidney injury after orthotopic liver transplantation[J].Chin Med J(Engl),2018,131(9):1059-1066.
[19]DE BOCCARDO G,KIM J Y,SCHIANO T D,et al.The burden of chronic kidney disease in long-term liver transplant recipients[J].Transplant Proc,2008,40(5):1498-503.
[20]MALHEIRO J,ALMEIDA M,FONSECA I,et al.Hyperuricemia in adult renal allograft recipients:Prevalence and predictors[J].Transplant Proc,2012,44(8):2369-2372.
[21]CLIVE D M.Renal transplant-associated hyperuricemia and gout[J].J Am Soc Nephrol,2000,11(5):974-979.
[22]TUMGOR G,ARIKAN C,KILIC M,et al.Frequency of hyperuricemia and effect of calcineurin inhibitors on serum uric acid levels in liver transplanted children[J].Pediatr Transplant,2006,10(6):665-668.
[23]SHIBOLET O,ELINAV E,ILAN Y,et al.Reduced incidence of hyperuricemia,gout,and renal failure following liver transplantation in comparison to heart transplantation:A long-term follow-up study[J].Transplantation,2004,77(10):1576-1580.
[24]MEIER-KRIESCHE H U,SCHOLD J D,VANRENTER-GHEM Y,et al.Uric acid levels have no significant effect on renal function in adult renal transplant recipients:Evidence from the symphony study[J].Clin J Am Soc Nephrol,2009,4(10):1655-1660.
[25]DUMORTIER J,COUCHONNAL E,LACAILLE F,et al.mTOR inhibitors in pediatric liver transplant recipients[J].Clin Res Hepatol Gastroenterol,2018.pii:S2210-7401(18)30267-5.
[26]TANNURI U,GIBELLI N E,MAKSOUD-FILHO J G,et al.Mycophenolate mofetil promotes prolonged improvement of renal dysfunction after pediatric liver transplantation:Experience of a single center[J].Pediatr Transplant,2007,11(1):82-86.
[27]MENTION K,LAHOCHE-MANUCCI A,BONNEVALLEM,et al.Renal function outcome in pediatric liver transplant recipients[J].Pediatr Transplant,2005,9(2):201-207.
[28]ISHINO K,MUTOH M,TOTSUKA Y,et al.Metabolic syndrome:A novel high-risk state for colorectal cancer[J].Cancer Lett,2013,28;334(1):56-61.
[29]HU L S,CHAI Y C,ZHENG J,et al.Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death[J].World J Gastroenterol,2018,21;24(43):4920-4927.
[30]D′AVOLA D,CUERVAS-MONS V,MARTI J,et al.Cardiovascular morbidity and mortality after liver transplantation:The protective role of mycophenolate mofetil[J].Liver Transpl,2017,23(4):498-509.
[2]饶伟萍,牛玉坚,王宏宇,等.肝移植术后高尿酸血症的发生率和相关危险因素分析:单中心回顾性研究[J].中华内分泌外科杂志,2015,9(6):493-496.
[3]MUREA M.Advanced kidney failure and hyperuricemia[J].Adv Chronic Kidney Dis,2012,19(6):419-424.
[4]SIMAO A N,LOZOVOY M A,DICHI I.The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome[J].EXPERT Opin Ther Targets,2012,16(12):1175-1187.
[5]葛均波,徐永健.内科学[M].8版.北京:人民卫生出版社,2014:792.
[6]LISA S,MARTIN S,JOHN O,et al.Gout in solid organ transplantation:A challenging clinical problem[J].Drugs,2005,65(18):2593-2611.
[7]KRISHNAN E,PANDYA B J,CHUNG L,et al.Hyperuricemia and the risk for subclinical coronary atherosclerosis-data from a prospective observational cohort study[J].Arthritis Res Ther,2011,13(2):R66.
[8]RUGGIERO C,CHERUBINI A,BLE A,et al.Uric acid and inflammatory markers[J].Eur Heart J,2006,27(10):1174-1181.
[9]ELSAYED A S,MOSTAFA M M,ABDELKHALIK A,et al.Hyperuricemia and its association with carotid intimamedia thickness in hypertensive and non hypertensive patients[J].J Saudi Heart Assoc,2010,22(1):19-23.
[10]MAZZALI M,HUGHES J,KIM Y G,et al.Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism[J].Hypertension,2001,38(5):1101-1106.
[11]KIM K M,KIM S S,YUN S,et al.Uric acid contributes to glomerular filtration rate deterioration in renal transplantation[J].Nephron Clin Prac,2011,118(2):c136-142.
[12]ERKMEN UYAR M,SEZER S,BAL Z,et al.Post-transplant hyperuricemia as a cardiovascular risk factor[J].Transplant Proc,2015,47(4):1146-1151.
[13]HUANG Y,LI Y L,HUANG H.Effects of hyperuricemia on renal function of renal transplant recepients:A systematic review and meta-analysis of cohort studies[J].PLoS One,2012,7(6):e39457.
[14]AKGUL A,BILGIC A,IBIS A,et al.Is uric acid a predictive factor for graft dysfunction in renal transplant recipients[J]?Transplant Proc,2007,39(4):1023-1026.
[15]HARIRIAN A,NOGUEIRA J M,ZANDI-NEJAD K,et al.The independent association between serum uric acid and graft outcomes after kidney transplantation[J].Transplantation,2010,89(5):573-579.
[16]HARAMBAT J,DUBOURG L,RANCHIN B,et al.Hyperuricemia after liver transplantation in children[J].Pediatr Transplant,2008,12(8):847-53.
[17]LONGENECKER J C,WAHEED S,BANDAK G,et al.Hyperuricemia after orthotopic liver transplantation:Divergent associations with progression of renal disease,incident endstage renal disease,and mortality[J].BMC Nephrol,2017,27;18(1):103.
[18]LU H Y,NING X Y,CHEN Y Q,et al.Predictive value of serum creatinine,blood urea nitrogen,uric acid,andβ2-microglobulin in the evaluation of acute kidney injury after orthotopic liver transplantation[J].Chin Med J(Engl),2018,131(9):1059-1066.
[19]DE BOCCARDO G,KIM J Y,SCHIANO T D,et al.The burden of chronic kidney disease in long-term liver transplant recipients[J].Transplant Proc,2008,40(5):1498-503.
[20]MALHEIRO J,ALMEIDA M,FONSECA I,et al.Hyperuricemia in adult renal allograft recipients:Prevalence and predictors[J].Transplant Proc,2012,44(8):2369-2372.
[21]CLIVE D M.Renal transplant-associated hyperuricemia and gout[J].J Am Soc Nephrol,2000,11(5):974-979.
[22]TUMGOR G,ARIKAN C,KILIC M,et al.Frequency of hyperuricemia and effect of calcineurin inhibitors on serum uric acid levels in liver transplanted children[J].Pediatr Transplant,2006,10(6):665-668.
[23]SHIBOLET O,ELINAV E,ILAN Y,et al.Reduced incidence of hyperuricemia,gout,and renal failure following liver transplantation in comparison to heart transplantation:A long-term follow-up study[J].Transplantation,2004,77(10):1576-1580.
[24]MEIER-KRIESCHE H U,SCHOLD J D,VANRENTER-GHEM Y,et al.Uric acid levels have no significant effect on renal function in adult renal transplant recipients:Evidence from the symphony study[J].Clin J Am Soc Nephrol,2009,4(10):1655-1660.
[25]DUMORTIER J,COUCHONNAL E,LACAILLE F,et al.mTOR inhibitors in pediatric liver transplant recipients[J].Clin Res Hepatol Gastroenterol,2018.pii:S2210-7401(18)30267-5.
[26]TANNURI U,GIBELLI N E,MAKSOUD-FILHO J G,et al.Mycophenolate mofetil promotes prolonged improvement of renal dysfunction after pediatric liver transplantation:Experience of a single center[J].Pediatr Transplant,2007,11(1):82-86.
[27]MENTION K,LAHOCHE-MANUCCI A,BONNEVALLEM,et al.Renal function outcome in pediatric liver transplant recipients[J].Pediatr Transplant,2005,9(2):201-207.
[28]ISHINO K,MUTOH M,TOTSUKA Y,et al.Metabolic syndrome:A novel high-risk state for colorectal cancer[J].Cancer Lett,2013,28;334(1):56-61.
[29]HU L S,CHAI Y C,ZHENG J,et al.Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death[J].World J Gastroenterol,2018,21;24(43):4920-4927.
[30]D′AVOLA D,CUERVAS-MONS V,MARTI J,et al.Cardiovascular morbidity and mortality after liver transplantation:The protective role of mycophenolate mofetil[J].Liver Transpl,2017,23(4):498-509.