血清瘦素、抵抗素和脂联素水平与子痫前期的相关性研究
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摘要
目的探讨瘦素、抵抗素和脂联素这三种脂肪因子的血清浓度与子痫前期发病是否存在相关性。方法采用病例对照研究,所有入组孕妇均来自中国医学科学院北京协和医学院北京协和医院。选取2013年1月至2015年6月期间就诊的74例子痫前期患者为病例组,并根据发病孕周将其分为早发型和晚发型(病例数分别为51例和23例),选取同期产检的无并发症足月分娩孕妇79例为对照组。3种脂肪因子采用酶联免疫吸附法测定。结果病例组和对照组相比,病例组的瘦素水平明显高于对照组[(34.23±22.48)μg/L vs.(15.84±8.98)μg/L,P<0.001],瘦素水平在对照组中与BMI呈正相关(r=0.651,P<0.001),但在病例组中这种相关性消失;病例组的血清抵抗素水平明显高于对照组[(14.08±6.10)μg/L vs.(9.99±8.33)μg/L,P<0.001],抵抗素水平与BMI并无相关性;脂联素水平在两组差异无统计学意义。结论血清抵抗素和瘦素在子痫前期孕妇中明显高于正常妊娠人群,其升高机制仍需进一步探索;脂联素与子痫前期的发生相关性并不明确。
Objective To investigate the relationship between serum leptin,resistin and adiponectin levels and preeclampsia.Methods The study was a case-control study.All enrolled pregnant women were selected from January2013 to June 2015 in Peking Union Medical College Hospital,Peking Union Medical College Peking Union Medical College Hospital.In the case group,74 patients were further divided into early-onset and late-onset subgroups(51 cases and 23 cases respectively).The control group enrolled 79 uncomplicated pregnant women who delivered full-term babies during the study period.Three adipokines were measured by enzyme linked immunosorbent assay.Results Leptin level8.98)μg/L,P<0.001).Positive correlation between leptin level and BMI was observed in normotensive pregnancies(r=0.651,P<0.001),but the correlation disappeared in preeclampsia patients.The serum resistin level in the case group was significantly higher than that in the control group(14.08±6.10)vs.(9.99±8.33)μg/L,P<0.001),and there was no correlation between serum resistin level and BMI.There was no significant difference in adiponectin level between the case group and the control group.Conclusion Serum resistin and leptin in preeclampsia population are significantly higher than those in normotensive pregnancies,and the underlying mechanism of their elevation needs to be further investigated.The correlation between adiponectin and preeclampsia is not clear.
Objective To investigate the relationship between serum leptin,resistin and adiponectin levels and preeclampsia.Methods The study was a case-control study.All enrolled pregnant women were selected from January2013 to June 2015 in Peking Union Medical College Hospital,Peking Union Medical College Peking Union Medical College Hospital.In the case group,74 patients were further divided into early-onset and late-onset subgroups(51 cases and 23 cases respectively).The control group enrolled 79 uncomplicated pregnant women who delivered full-term babies during the study period.Three adipokines were measured by enzyme linked immunosorbent assay.Results Leptin level8.98)μg/L,P<0.001).Positive correlation between leptin level and BMI was observed in normotensive pregnancies(r=0.651,P<0.001),but the correlation disappeared in preeclampsia patients.The serum resistin level in the case group was significantly higher than that in the control group(14.08±6.10)vs.(9.99±8.33)μg/L,P<0.001),and there was no correlation between serum resistin level and BMI.There was no significant difference in adiponectin level between the case group and the control group.Conclusion Serum resistin and leptin in preeclampsia population are significantly higher than those in normotensive pregnancies,and the underlying mechanism of their elevation needs to be further investigated.The correlation between adiponectin and preeclampsia is not clear.
引文
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[8]中华人民共和国卫生和计划生育委员会.中华人民共和国卫生行业标准:成人体重判定(WS/T428-2013)[M].中国标准出版社,2013.
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[10]Salimi S,Farajian-Mashhadi F,Naghavi A,et al.Different profile of serum leptin between early onset and late onset preeclampsia[J].Dis Markers,2014,46:628476.
[11]Angelidis G,Dafopoulos K,Messini CI,et al.The emerging roles of adiponectin in female reproductive system-associated disorders and pregnancy[J].Reprod Sci,2013,20(8):872-881.
[12]Haghiac M,Basu S,Presley L,et al.Patterns of adiponectin expression in term pregnancy:impact of obesity[J].J Clin Endocrinol Metab,2014,99(9):3427-3434.2018-12-152019-01-20
[2]Christiansen M,Hedley PL,Placing S,et al.Maternal serum resistin is reduced in first trimester preeclampsia pregnancies and is a marker of clinical severity[J].Hypertens Pregnancy,2015,34(4):422-433.
[3]郑东颖,乔宠.子痫前期导致死胎预测方法的研究进展[J].中国实用妇科与产科杂志,2017,33(11):1137-1141.
[4]Briana DD,Malamitsi-Puchner A.Reviews:adipocytokines in normal and complicated pregnancies[J].Reprod Sci,2009,16(10):921-937.
[5]Wang Y,Liu RX,Liu H.Association of adiponectin gene polymorphisms with hypertensive disorder complicating pregnancy and disorders of lipid metabolism[J].Genet Mol Res,2015,14(4):15213-15223.
[6]王广娇,杨孜.脂代谢和脂肪酸代谢与子痫前期[J].中国实用妇科与产科杂志,2018,34(9):966-970.
[7]Chen X,Scholl TO.Ethnic differences in maternal adipokines during normal pregnancy[J].Int J Environ Res Public Health,2015,13(1):ijerph13010008.
[8]中华人民共和国卫生和计划生育委员会.中华人民共和国卫生行业标准:成人体重判定(WS/T428-2013)[M].中国标准出版社,2013.
[9]Song Y,Gao J,Qu Y,et al.Serum levels of leptin,adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia[J].Clin Chim Acta,2016,458:133-137.
[10]Salimi S,Farajian-Mashhadi F,Naghavi A,et al.Different profile of serum leptin between early onset and late onset preeclampsia[J].Dis Markers,2014,46:628476.
[11]Angelidis G,Dafopoulos K,Messini CI,et al.The emerging roles of adiponectin in female reproductive system-associated disorders and pregnancy[J].Reprod Sci,2013,20(8):872-881.
[12]Haghiac M,Basu S,Presley L,et al.Patterns of adiponectin expression in term pregnancy:impact of obesity[J].J Clin Endocrinol Metab,2014,99(9):3427-3434.2018-12-152019-01-20