肿瘤微环境胶原变化和肿瘤转移的研究进展
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摘要
恶性肿瘤的危害在于侵袭和远处转移,肿瘤微环境中胶原变化和肿瘤转移密切相关。肿瘤微环境中胶原变化主要表现在新生胶原、密度、方向、长度、交联等方面,这些变化可以通过影响肿瘤细胞的代谢、水扩散和大分子运输、基因表达、血管生成等方面,也可以通过促进上皮间充质转化、免疫和基质细胞等来影响肿瘤的侵袭转移。深入了解肿瘤微环境中胶原变化和肿瘤转移的关系对于防治肿瘤具有积极的指导意义。
引文
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[26]TORZILLI P A,BOURNE J W,CIGLER T,et al.A new paradigm for mechanobiological mechanisms in tumor metastasis[J].Semin Cancer Biol,2012,22(5/6):385-395.
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[29]RICHING K M,COX B L,SALICK M R,et al.3Dcollagen alignment limits protrusions to enhance breast cancer cell persistence[J].Biophys J,2014,107(11):2546-2558.
[30]GARCIA-MENDOZA M G,INMAN D R,PONIK S M,et al.Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment[J].Breast Cancer Res,2016,18(1):49.
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[32]POLLARD J W.Tumour-educated macrophages promote tumour progression and metastasis[J].Nat Rev Cancer,2004,4(1):71-78.
[33]KAPLAN G.In vitro differentiation of human monocytes.Monocytes cultured on glass are cytotoxic to tumor cells but monocytes cultured on collagen are not[J].J Exp Med,1983,157(6):2061-2072.
[34]WEATHINGTON N M,VAN HOUWELINGEN A H,NOERAGER B D,et al.A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation[J].Nat Med,2006,12(3):317-323.
[35]POSTLETHWAITE A E,KANG A H.Collagen-and collagen peptide-induced chemotaxis of human blood monocytes[J].J Exp Med,1976,143(6):1299-1307.
[36]BINGLE L,BROWN N J,LEWIS C E.The role of tumourassociated macrophages in tumour progression:implications for new anticancer therapies[J].J Pathol,2002,196(3):254-265.
[37]CARMELIET P,JAIN R K.Angiogenesis in cancer and other diseases[J].Nature,2000,407(6801):249-257.
[38]BOUDREAU N,MYERS C.Breast cancer-induced angiogenesis:multiple mechanisms and the role of the microenvironment[J].Breast Cancer Res,2003,5(3):140-146.
[39]ROTH J M,CAUNT M,CRETU A,et al.Inhibition of experimental metastasis by targeting the HUIV26cryptic epitope in collagen[J].Am J Pathol,2006,168(5):1576-1586.
[40]MORRIS B A,BURKEL B,PONIK S M,et al.Collagen matrix density drives the metabolic shift in breast cancer cells[J].EBioMedicine,2016,13:146-156.
[41]KAKKAD S,ZHANG J,AKHBARDEH A,et al.Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers[J].Neoplasia,2016,18(10):585-593.
[42]ESBONA K,INMAN D,SAHA S,et al.COX-2 modulates mammary tumor progression in response to collagen density[J].Breast Cancer Res,2016,18(1):35.
[43]VELLINGA T T,DEN UIL S,RINKES I H,et al.Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion[J].Oncogene,2016,35(40):5263-5271.
[44]HUIJBERS I J,IRAVANI M,POPOV S,et al.A role for fibrillar collagen deposition and the collagen internalization receptor endo180in glioma invasion[J].PLoS One,2010,5(3):e9808.
[45]MARAGOUDAKIS M E,MISSIRLIS E,KARAKIULAKIS G D,et al.Basement membrane biosynthesis as a target for developing inhibitors of angiogenesis with anti-tumor properties[J].Kidney Int,1993,43(1):147-150.
[46]KALLURI R.Basement membranes:structure,assembly and role in tumour angiogenesis[J].Nat Rev Cancer,2003,3(6):422-433.
[47]KEHLET S N,SANZ-PAMPLONA R,BRIX S,et al.Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients[J].Sci Rep,2016,6:30599.
[2]MAKAREEVA E,HAN S,VERA J C,et al.Carcinomas contain a matrix metalloproteinase-resistant isoform of typeⅠcollagen exerting selective support to invasion[J].Cancer Res,2010,70(11):4366-4374.
[3]CARON J M,AMES J J,CONTOIS L,et al.Inhibition of ovarian tumor growth by targeting the HU177cryptic collagen epitope[J].Am J Pathol,2016,186(6):1649-1661.
[4]GILKES D M,CHATURVEDI P,BAJPAI S,et al.Collagen prolyl hydroxylases are essential for breast cancer metastasis[J].Cancer Res,2013,73(11):3285-3296.
[5]PAGE-MCCAW A,EWALD A J,WERB Z.Matrix metalloproteinases and the regulation of tissue remodelling[J].Nat Rev Mol Cell Biol,2007,8(3):221-233.
[6]JABLONSKA-TRYPUC A,MATEJCZYK M,ROSOCHACKI S.Matrix metalloproteinases(MMPs),the main extracellular matrix(ECM)enzymes in collagen degradation,as a target for anticancer drugs[J].J Enzyme Inhib Med Chem,2016,31(Supp 1):177-183.
[7]RATH N,MORTON J P,JULIAN L,et al.ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth[J].EMBO Mol Med,2017,9(2):198-218.
[8]CLARKE C J,BERG T J,BIRCH J,et al.The initiator methionine tRNA drives secretion of typeⅡcollagen from stromal fibroblasts to promote tumor growth and angiogenesis[J].Curr Biol,2016,26(6):755-765.
[9]BRISSON B K,MAULDIN E A,LEI W,et al.TypeⅢcollagen directs stromal organization and limits metastasis in a murine model of breast cancer[J].Am J Pathol,2015,185(5):1471-1486.
[10]NYSTROM H,NAREDI P,BERGLUND A,et al.Livermetastatic potential of colorectal cancer is related to the stromal composition of the tumour[J].Anticancer Res,2012,32(12):5183-5191.
[11]PARRA E R,ALVENO R A,FAUSTINO C B,et al.Intranasal administration of typeⅤcollagen reduces lung carcinogenesis through increasing endothelial and epithelial apoptosis in a urethane-induced lung tumor model[J].Arch Immunol Ther Exp(Warsz),2016,64(4):321-329.
[12]WANG K,WU F,SEO B R,et al.Breast cancer cells alter the dynamics of stromal fibronectin-collagen interactions[J].Matrix Biol,2017(60/61):86-95.
[13]FANG M,YUAN J,PENG C,et al.Collagen as a doubleedged sword in tumor progression[J].Tumour Biol,2014,35(4):2871-2882.
[14]PROVENZANO P P,INMAN D R,ELICEIRI K W,et al.Collagen density promotes mammary tumor initiation and progression[J].BMC Med,2008,6:11.
[15]RIZWAN A,BULTE C,KALAICHELVAN A,et al.Metastatic breast cancer cells in lymph nodes increase nodal collagen density[J].Sci Rep,2015,5:10002.
[16]UCHUGONOVA A,ZHAO M,WEINIGEL M,et al.Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer-cell anchorage and shape[J].J Cell Biochem,2013,114(1):99-102.
[17]PROVENZANO P P,ELICEIRI K W,CAMPBELL J M,et al.Collagen reorganization at the tumor-stromal interface facilitates local invasion[J].BMC Med,2006,4(1):38.
[18]WYCKOFF J B,WANG Y,LIN E Y,et al.Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors[J].Cancer Res,2007,67(6):2649-2656.
[19]HAN W,CHEN S,YUAN W,et al.Oriented collagen fibers direct tumor cell intravasation[J].Proc Natl Acad Sci U S A,2016,113(40):11208-11213.
[20]BURKE K A,DAWES R P,CHEEMA M K,et al.Second-harmonic generation scattering directionality predicts tumor cell motility in collagen gels[J].J Biomed Opt,2015,20(5):51024.
[21]HANLEY C J,NOBLE F,WARD M,et al.A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation,which is prognostic in multiple cancers[J].Oncotarget,2016,7(5):6159-6174.
[22]LEVENTAL K R,YU H,KASS L,et al.Matrix crosslinking forces tumor progression by enhancing integrin signaling[J].Cell,2009,139(5):891-906.
[23]CHEN Y,TERAJIMA M,YANG Y,et al.Lysyl hydroxylase 2induces a collagen cross-link switch in tumor stroma[J].J Clin Invest,2015,125(3):1147-1162.
[24]WANG T H,HSIA S M,SHIEH T M.Lysyl oxidase and the tumor microenvironment[J].Int J Mol Sci,2016,18(1):E62.
[25]MOTRESCU E R,BLAISE S,ETIQUE N,et al.Matrix metalloproteinase-11/stromelysin-3exhibits collagenolytic function against collagenⅥunder normal and malignant conditions[J].Oncogene,2008,27(49):6347-6355.
[26]TORZILLI P A,BOURNE J W,CIGLER T,et al.A new paradigm for mechanobiological mechanisms in tumor metastasis[J].Semin Cancer Biol,2012,22(5/6):385-395.
[27]ESSEX D W,LI M,MILLER A,et al.Protein disulfide isomerase and sulfhydryl-dependent pathways in platelet activation[J].Biochemistry,2001,40(20):6070-6075.
[28]NETTI P A,BERK D A,SWARTZ M A,et al.Role of extracellular matrix assembly in interstitial transport in solid tumors[J].Cancer Res,2000,60(9):2497-2503.
[29]RICHING K M,COX B L,SALICK M R,et al.3Dcollagen alignment limits protrusions to enhance breast cancer cell persistence[J].Biophys J,2014,107(11):2546-2558.
[30]GARCIA-MENDOZA M G,INMAN D R,PONIK S M,et al.Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment[J].Breast Cancer Res,2016,18(1):49.
[31]PARKS W C,WILSON C L,LOPEZ-BOADO Y S.Matrix metalloproteinases as modulators of inflammation and innate immunity[J].Nat Rev Immunol,2004,4(8):617-629.
[32]POLLARD J W.Tumour-educated macrophages promote tumour progression and metastasis[J].Nat Rev Cancer,2004,4(1):71-78.
[33]KAPLAN G.In vitro differentiation of human monocytes.Monocytes cultured on glass are cytotoxic to tumor cells but monocytes cultured on collagen are not[J].J Exp Med,1983,157(6):2061-2072.
[34]WEATHINGTON N M,VAN HOUWELINGEN A H,NOERAGER B D,et al.A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation[J].Nat Med,2006,12(3):317-323.
[35]POSTLETHWAITE A E,KANG A H.Collagen-and collagen peptide-induced chemotaxis of human blood monocytes[J].J Exp Med,1976,143(6):1299-1307.
[36]BINGLE L,BROWN N J,LEWIS C E.The role of tumourassociated macrophages in tumour progression:implications for new anticancer therapies[J].J Pathol,2002,196(3):254-265.
[37]CARMELIET P,JAIN R K.Angiogenesis in cancer and other diseases[J].Nature,2000,407(6801):249-257.
[38]BOUDREAU N,MYERS C.Breast cancer-induced angiogenesis:multiple mechanisms and the role of the microenvironment[J].Breast Cancer Res,2003,5(3):140-146.
[39]ROTH J M,CAUNT M,CRETU A,et al.Inhibition of experimental metastasis by targeting the HUIV26cryptic epitope in collagen[J].Am J Pathol,2006,168(5):1576-1586.
[40]MORRIS B A,BURKEL B,PONIK S M,et al.Collagen matrix density drives the metabolic shift in breast cancer cells[J].EBioMedicine,2016,13:146-156.
[41]KAKKAD S,ZHANG J,AKHBARDEH A,et al.Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers[J].Neoplasia,2016,18(10):585-593.
[42]ESBONA K,INMAN D,SAHA S,et al.COX-2 modulates mammary tumor progression in response to collagen density[J].Breast Cancer Res,2016,18(1):35.
[43]VELLINGA T T,DEN UIL S,RINKES I H,et al.Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion[J].Oncogene,2016,35(40):5263-5271.
[44]HUIJBERS I J,IRAVANI M,POPOV S,et al.A role for fibrillar collagen deposition and the collagen internalization receptor endo180in glioma invasion[J].PLoS One,2010,5(3):e9808.
[45]MARAGOUDAKIS M E,MISSIRLIS E,KARAKIULAKIS G D,et al.Basement membrane biosynthesis as a target for developing inhibitors of angiogenesis with anti-tumor properties[J].Kidney Int,1993,43(1):147-150.
[46]KALLURI R.Basement membranes:structure,assembly and role in tumour angiogenesis[J].Nat Rev Cancer,2003,3(6):422-433.
[47]KEHLET S N,SANZ-PAMPLONA R,BRIX S,et al.Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients[J].Sci Rep,2016,6:30599.
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