儿童脓疱型银屑病治疗进展
|
摘要
儿童银屑病是一种常见的炎症性皮肤病,而儿童脓疱型银屑病(Childhood pustular psoriasis,CPP)较为少见,是一种发生于儿童的全身性炎症性伴皮肤功能障碍的银屑病类型。CPP顽固且易复发,对患儿及其父母生活质量及发展都影响颇大。对于CPP,皮肤的局部治疗是必不可少的基础,维甲酸类、甲氨蝶呤、环孢素、生物制剂等为系统治疗中的常用药物,脓疱型银屑病儿童通常对光疗有较好的反应。此文介绍了目前针对于儿童脓疱型银屑病的治疗共识与经验,为现在的治疗进展进行了概括。
引文
[1]Wu Y,Lin Y,Liu HJ,et al.Childhood psoriasis:a study of 137cases from central China[J].World J Pediatr,2010,6:260-264.
[2]Tsang V,Dvorakova V,Enright F,et al.Successful use of infliximab as first line treatment for severe childhood generalized pustular psoriasis[J].J Eur Acad Dermatol Venereol,2016,30:e117-119.
[3]王艺蓉,程茹虹,李明,等.儿童急性泛发性脓疱型银屑病外周血参数分析[J].中国麻风皮肤病杂志,2015,31(10):586-588.
[4]王倩,刘伟,张丽霞.儿童泛发性脓疱型银屑病43例临床分析[J].中国麻风皮肤病杂志,2016,32(3):136-138.
[5]Lysell J,Padyukov L,Kockum I,et al.Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06[J].J Invest Dermatol,2013,133:411-417.
[6]Ellingford JM,Black GC,Clayton TH,et al.A novel mutation in IL36RN underpins childhood pustular dermatosis[J].J Eur Acad Dermatol Venereol,2016,30:302-305.
[7]Popadic S,Nikolic M.Pustular psoriasis in childhood and adolescence:a 20-year single-center experience[J].Pediatr Dermatol,2014,31:575-579.
[8]Moustou AE,Kakourou T,Masouri S,et al.Childhood and adolescent psoriasis in Greece:a retrospective analysis of 842patients[J].Int J Dermatol,2014,53:1 447-1 453.
[9]Haug V,Benoit S,Wohlleben M,et al.Annular pustular psoriasis in a 14-month-old girl:a therapeutic challenge[J].J Dermatolog Treat,2017,28:520-522.
[10]Burden-Teh E,Thomas KS,Ratib S,et al.The epidemiology of childhood psoriasis:a scoping review[J].Br J Dermatol,2016,174:1 242-1 257.
[11]Fluhr JW,Cavallotti C,Berardesca E.Emollients,moisturizers,and keratolytic agents in psoriasis[J].Clin Dermatol,2008,26:380-386.
[12]罗蕊雨,欧阳莹.儿童银屑病治疗进展[J].儿科药学杂志,2016,22(2):59-62.
[13]冯小燕,李钦峰.儿童银屑病治疗的进展[J].中国中西医结合皮肤性病学杂志,2017,16(3):283-285.
[14]慕珍珍,杨帆,张悦,等.维A酸类药物治疗儿童皮肤病的临床应用进展[J].中国皮肤性病学杂志,2016,30(3):308-310.
[15]Di Lernia V,Bonamonte D,Lasagni C,et al.Effectiveness and safety of acitretin in children with plaque psoriasis:a multicenter retrospective analysis[J].Pediatr Dermatol,2016,33:530-535.
[16]Bulbul BE,Yazici S,Tunali S,et al.Clinical experience with systemic cyclosporine A treatment in severe childhood psoriasis[J].JDermatolog Treat,2016,27:328-331.
[17]陈蕊.儿童泛发性脓疱型银屑病46例临床分析[D].郑州大学,2014.
[18]吴波.阿维A联合环孢素治疗儿童脓疱型银屑病60例[J].中国药业,2013,22(23):82-83.
[19]Napolitano M,Megna M,Balato A,et al.Systemic treatment of pediatric psoriasis:a review[J].Dermatol Ther(Heidelb),2016,6:125-142.
[20]Charbit L,Mahe E,Phan A,et al.Systemic treatments in childhood psoriasis:a French multicentre study on 154 children[J].Br JDermatol,2016,174:1 118-1 121.
[21]罗蕊雨.阿维A治疗儿童脓疱型银屑病临床疗效对比分析[D].重庆医科大学,2015.
[22]Skrabl-Baumgartner A,Weger W,Salmhofer W,et al.Childhood generalized pustular psoriasis:longtime remission with combined infliximab and methotrexate treatment[J].Pediatr Dermatol,2015,32:e13-e14.
[23]Kim HS,Kim GM,Kim SY.Two-stage therapy for childhood generalized pustular psoriasis:low-dose cyclosporin for induction and maintenance with acitretin/narrowband ultraviolet Bphototherapy[J].Pediatr Dermatol,2006,23:306-308.
[24]Takahashi M,Takeuchi M,Matsunaga K.Infant with generalized pustular psoriasis who responded to cyclosporin A therapy[J].JDermatol,2015,42:911-913.
[25]Posso-De LRC,Pope E,Lara-Corrales I.A systematic review of systemic medications for pustular psoriasis in pediatrics[J].Pediatr Dermatol,2014,31:430-439.
[26]Saikaly SK,Mattes M.Biologics and pediatric generalized pustular psoriasis:an emerging therapeutic trend[J].Cureus,2016,8:e652.
[27]Fialova J,Vojackova N,Vanousova D,et al.Juvenile generalized pustular psoriasis treated with etanercept[J].Dermatol Ther,2014,27:105-108.
[28]Pan J,Qiu L,Xiao T,et al.Juvenile generalized pustular psoriasis with IL36RN mutation treated with short-term infliximab[J].Dermatol Ther,2016,29:164-167.
[29]Mahe E,Gnossike P,Sigal ML.Childhood psoriasis[J].Arch Pediatr,2014,21:778-786.
[30]Sticherling M,Augustin M,Boehncke WH,et al.Therapy of psoriasis in childhood and adolescence-a German expert consensus[J].J Dtsch Dermatol Ges,2011,9:815-823.
[31]Wong Y,Koh MJ,Chong WS.Role of Narrowband ultraviolet Bphototherapy in the treatment of childhood psoriasis in Asian children[J].Pediatr Dermatol,2015,32:e221-223.
[32]Sen BB,Rifaioglu EN,Ekiz O,et al.Narrow-band ultraviolet Bphototherapy in childhood[J].Cutan Ocul Toxicol,2014,33:189-191.
[33]Lee WK,Kim JM,Kim GW,et al.Recalcitrant infantile generalized pustular psoriasis successfully treated with acitretin and narrowband ultraviolet B[J].J Dermatol,2018,45:330-331.
[34]Kopp T,Karlhofer F,Szepfalusi Z,et al.Successful use of acitretin in conjunction with narrowband ultraviolet B phototherapy in a child with severe pustular psoriasis,von Zumbusch type[J].Br J Dermatol,2004,151:912-916.
[2]Tsang V,Dvorakova V,Enright F,et al.Successful use of infliximab as first line treatment for severe childhood generalized pustular psoriasis[J].J Eur Acad Dermatol Venereol,2016,30:e117-119.
[3]王艺蓉,程茹虹,李明,等.儿童急性泛发性脓疱型银屑病外周血参数分析[J].中国麻风皮肤病杂志,2015,31(10):586-588.
[4]王倩,刘伟,张丽霞.儿童泛发性脓疱型银屑病43例临床分析[J].中国麻风皮肤病杂志,2016,32(3):136-138.
[5]Lysell J,Padyukov L,Kockum I,et al.Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06[J].J Invest Dermatol,2013,133:411-417.
[6]Ellingford JM,Black GC,Clayton TH,et al.A novel mutation in IL36RN underpins childhood pustular dermatosis[J].J Eur Acad Dermatol Venereol,2016,30:302-305.
[7]Popadic S,Nikolic M.Pustular psoriasis in childhood and adolescence:a 20-year single-center experience[J].Pediatr Dermatol,2014,31:575-579.
[8]Moustou AE,Kakourou T,Masouri S,et al.Childhood and adolescent psoriasis in Greece:a retrospective analysis of 842patients[J].Int J Dermatol,2014,53:1 447-1 453.
[9]Haug V,Benoit S,Wohlleben M,et al.Annular pustular psoriasis in a 14-month-old girl:a therapeutic challenge[J].J Dermatolog Treat,2017,28:520-522.
[10]Burden-Teh E,Thomas KS,Ratib S,et al.The epidemiology of childhood psoriasis:a scoping review[J].Br J Dermatol,2016,174:1 242-1 257.
[11]Fluhr JW,Cavallotti C,Berardesca E.Emollients,moisturizers,and keratolytic agents in psoriasis[J].Clin Dermatol,2008,26:380-386.
[12]罗蕊雨,欧阳莹.儿童银屑病治疗进展[J].儿科药学杂志,2016,22(2):59-62.
[13]冯小燕,李钦峰.儿童银屑病治疗的进展[J].中国中西医结合皮肤性病学杂志,2017,16(3):283-285.
[14]慕珍珍,杨帆,张悦,等.维A酸类药物治疗儿童皮肤病的临床应用进展[J].中国皮肤性病学杂志,2016,30(3):308-310.
[15]Di Lernia V,Bonamonte D,Lasagni C,et al.Effectiveness and safety of acitretin in children with plaque psoriasis:a multicenter retrospective analysis[J].Pediatr Dermatol,2016,33:530-535.
[16]Bulbul BE,Yazici S,Tunali S,et al.Clinical experience with systemic cyclosporine A treatment in severe childhood psoriasis[J].JDermatolog Treat,2016,27:328-331.
[17]陈蕊.儿童泛发性脓疱型银屑病46例临床分析[D].郑州大学,2014.
[18]吴波.阿维A联合环孢素治疗儿童脓疱型银屑病60例[J].中国药业,2013,22(23):82-83.
[19]Napolitano M,Megna M,Balato A,et al.Systemic treatment of pediatric psoriasis:a review[J].Dermatol Ther(Heidelb),2016,6:125-142.
[20]Charbit L,Mahe E,Phan A,et al.Systemic treatments in childhood psoriasis:a French multicentre study on 154 children[J].Br JDermatol,2016,174:1 118-1 121.
[21]罗蕊雨.阿维A治疗儿童脓疱型银屑病临床疗效对比分析[D].重庆医科大学,2015.
[22]Skrabl-Baumgartner A,Weger W,Salmhofer W,et al.Childhood generalized pustular psoriasis:longtime remission with combined infliximab and methotrexate treatment[J].Pediatr Dermatol,2015,32:e13-e14.
[23]Kim HS,Kim GM,Kim SY.Two-stage therapy for childhood generalized pustular psoriasis:low-dose cyclosporin for induction and maintenance with acitretin/narrowband ultraviolet Bphototherapy[J].Pediatr Dermatol,2006,23:306-308.
[24]Takahashi M,Takeuchi M,Matsunaga K.Infant with generalized pustular psoriasis who responded to cyclosporin A therapy[J].JDermatol,2015,42:911-913.
[25]Posso-De LRC,Pope E,Lara-Corrales I.A systematic review of systemic medications for pustular psoriasis in pediatrics[J].Pediatr Dermatol,2014,31:430-439.
[26]Saikaly SK,Mattes M.Biologics and pediatric generalized pustular psoriasis:an emerging therapeutic trend[J].Cureus,2016,8:e652.
[27]Fialova J,Vojackova N,Vanousova D,et al.Juvenile generalized pustular psoriasis treated with etanercept[J].Dermatol Ther,2014,27:105-108.
[28]Pan J,Qiu L,Xiao T,et al.Juvenile generalized pustular psoriasis with IL36RN mutation treated with short-term infliximab[J].Dermatol Ther,2016,29:164-167.
[29]Mahe E,Gnossike P,Sigal ML.Childhood psoriasis[J].Arch Pediatr,2014,21:778-786.
[30]Sticherling M,Augustin M,Boehncke WH,et al.Therapy of psoriasis in childhood and adolescence-a German expert consensus[J].J Dtsch Dermatol Ges,2011,9:815-823.
[31]Wong Y,Koh MJ,Chong WS.Role of Narrowband ultraviolet Bphototherapy in the treatment of childhood psoriasis in Asian children[J].Pediatr Dermatol,2015,32:e221-223.
[32]Sen BB,Rifaioglu EN,Ekiz O,et al.Narrow-band ultraviolet Bphototherapy in childhood[J].Cutan Ocul Toxicol,2014,33:189-191.
[33]Lee WK,Kim JM,Kim GW,et al.Recalcitrant infantile generalized pustular psoriasis successfully treated with acitretin and narrowband ultraviolet B[J].J Dermatol,2018,45:330-331.
[34]Kopp T,Karlhofer F,Szepfalusi Z,et al.Successful use of acitretin in conjunction with narrowband ultraviolet B phototherapy in a child with severe pustular psoriasis,von Zumbusch type[J].Br J Dermatol,2004,151:912-916.