肺癌的“痰毒瘀”微观模型初探
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摘要
文章主要从肺癌的中医宏观病机"虚""痰""瘀""毒"出发,进一步论述了肺癌的微观病机是"痰""毒""瘀"的胶结渗透,包括"痰瘀""瘀毒"和"痰毒"3个方面。最后提出了肺癌的"痰毒瘀"微观模型并作了详细的分析,同时阐述了"痰毒瘀"微观模型的致病特点。
Starting from the macroscopic pathogenesis of lung cancer in traditional Chinese medicine(TCM) including 'deficiency' 'phlegm' 'stasis' and 'toxin', it was further discussed that the microscopic pathogenesis of lung cancer was the cementation and infiltration of 'phlegm' 'toxin' and 'stasis', including three aspects: 'phlegm and stasis', 'stasis and toxin' and 'phlegm and toxin'. Finally, the microscopic model of 'phlegm-toxin-stasis' of lung cancer was put forward and analyzed in detail, and the pathogenic characteristics of 'phlegm-toxin-stasis' microcosmic model were also expounded.
Starting from the macroscopic pathogenesis of lung cancer in traditional Chinese medicine(TCM) including 'deficiency' 'phlegm' 'stasis' and 'toxin', it was further discussed that the microscopic pathogenesis of lung cancer was the cementation and infiltration of 'phlegm' 'toxin' and 'stasis', including three aspects: 'phlegm and stasis', 'stasis and toxin' and 'phlegm and toxin'. Finally, the microscopic model of 'phlegm-toxin-stasis' of lung cancer was put forward and analyzed in detail, and the pathogenic characteristics of 'phlegm-toxin-stasis' microcosmic model were also expounded.
引文
[1]Jemal A,Bray F,Center M M,et al.Global cancer statistics.CA Cancer J Clin,2011,61(2):69-90
[2]LIU Y,YU S,LIU S,et al.Comparison of nedaplatin-based versus cisplatin-based chemotherapy for advanced non-small cell lung cancer among East Asian populations:a meta-analysis.Sci Rep,2015,5:10516
[3]Bronte G,Rolfo C,Passiglia F,et al.What can platinum offer yet in the treatment of PS2 NSCLC patients:a systematic review and meta-analysis.Crit Rev Oncol Hematol,2015,95(3):306-317
[4]孙建立,刘嘉湘,徐蔚杰.原发性支气管肺癌中医证的特征研究.中国中医基础医学杂志,2007,13(7):536-537
[5]蒋士卿,孙宏新,朴炳奎.益肺清化膏对荷瘤小鼠瘤组CD44、CD44v6、E-cad等m RNA表达水平的影响.中医学报,2010,1(1):17-20
[6]胡小梅,张培彤,杨宗艳,等.非小细胞肺癌不同病理类型与中医证候分布规律关系探讨.中国中医药信息杂志,2006,13(12):19-21
[7]刘永惠,杨晓峰,周冬枝,等.肿瘤转移与血瘀证的临床研究.中国中医基础医学杂志,2002,8(4):50-58
[8]第五永长,李妮矫.论中医“毒”概念的演变及其阴阳属性.中华中医药杂志,2010,25(5):654-657
[9]郭建辉,王志英.周仲瑛从癌毒论治肺癌学术思想举要.辽宁中医杂志,2012,39(3):410-411
[10]MAO Y,KELLER E T,GARFIELD D H,et al.Stromal cells in tumor microenvironment and breast cancer.Cancer Metastasis Rev,2013,32(1-2):303-315
[11]TUXHORN J A,MCALHALLY S J,DANG T D,et al.Stromal cells promote angiogenesis and growth of human prostate tumorsin a differential reactive stroma(DRS)xenograft model.Cancer Res,2002,62(11):3298-3307
[12]ALBINI A,MAGNANI E,NOONAN D M.The tumor microenvironment:biology of a complex cellular and tissue society.Q J Nucl Med Mol Imaging,2010,54(3):244-248
[13]陈滨海,庞德湘,张雅丽,等.肺金生方通过调控MMP-2/TIMP-2平衡抗肺癌侵袭转移研究.中华中医药学刊,2015,33(12):2900-2902
[14]张广顺,张光霁,廖广辉,等.藤梨根总三萜化合物通过下调N-Cadherin、Snail抑制BGC-823胃癌细胞侵袭的体内外实验研究.中华中医药杂志,2016,31(4):1188-1192
[15]常虹,张光霁.三氧化二砷联合丹参酮胶囊抗肝癌细胞bel-7404的研究.中华中医药杂志,2015,30(11):3881-3885
[16]陈滨海,张雅丽,姚成,等.基于肿瘤微环境学说探讨肺癌转移与痰毒的关系.中华中医药学刊,2015,33(9):2079-2081
[2]LIU Y,YU S,LIU S,et al.Comparison of nedaplatin-based versus cisplatin-based chemotherapy for advanced non-small cell lung cancer among East Asian populations:a meta-analysis.Sci Rep,2015,5:10516
[3]Bronte G,Rolfo C,Passiglia F,et al.What can platinum offer yet in the treatment of PS2 NSCLC patients:a systematic review and meta-analysis.Crit Rev Oncol Hematol,2015,95(3):306-317
[4]孙建立,刘嘉湘,徐蔚杰.原发性支气管肺癌中医证的特征研究.中国中医基础医学杂志,2007,13(7):536-537
[5]蒋士卿,孙宏新,朴炳奎.益肺清化膏对荷瘤小鼠瘤组CD44、CD44v6、E-cad等m RNA表达水平的影响.中医学报,2010,1(1):17-20
[6]胡小梅,张培彤,杨宗艳,等.非小细胞肺癌不同病理类型与中医证候分布规律关系探讨.中国中医药信息杂志,2006,13(12):19-21
[7]刘永惠,杨晓峰,周冬枝,等.肿瘤转移与血瘀证的临床研究.中国中医基础医学杂志,2002,8(4):50-58
[8]第五永长,李妮矫.论中医“毒”概念的演变及其阴阳属性.中华中医药杂志,2010,25(5):654-657
[9]郭建辉,王志英.周仲瑛从癌毒论治肺癌学术思想举要.辽宁中医杂志,2012,39(3):410-411
[10]MAO Y,KELLER E T,GARFIELD D H,et al.Stromal cells in tumor microenvironment and breast cancer.Cancer Metastasis Rev,2013,32(1-2):303-315
[11]TUXHORN J A,MCALHALLY S J,DANG T D,et al.Stromal cells promote angiogenesis and growth of human prostate tumorsin a differential reactive stroma(DRS)xenograft model.Cancer Res,2002,62(11):3298-3307
[12]ALBINI A,MAGNANI E,NOONAN D M.The tumor microenvironment:biology of a complex cellular and tissue society.Q J Nucl Med Mol Imaging,2010,54(3):244-248
[13]陈滨海,庞德湘,张雅丽,等.肺金生方通过调控MMP-2/TIMP-2平衡抗肺癌侵袭转移研究.中华中医药学刊,2015,33(12):2900-2902
[14]张广顺,张光霁,廖广辉,等.藤梨根总三萜化合物通过下调N-Cadherin、Snail抑制BGC-823胃癌细胞侵袭的体内外实验研究.中华中医药杂志,2016,31(4):1188-1192
[15]常虹,张光霁.三氧化二砷联合丹参酮胶囊抗肝癌细胞bel-7404的研究.中华中医药杂志,2015,30(11):3881-3885
[16]陈滨海,张雅丽,姚成,等.基于肿瘤微环境学说探讨肺癌转移与痰毒的关系.中华中医药学刊,2015,33(9):2079-2081