中兽药超微粉碎工艺研究

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英文篇名：Study on Ultrafine Grinding Process of Traditional Chinese Veterinary Medi?cine 作者：李龙瑞 ; 张吉鹍 ; 张庆生 ; 赖贻奎 ; 黎观红 ; 陈金兴 ; 邵智军 ; 李检香 英文作者：Li Longrui;Zhang Jikun;Zhang Qingsheng;Lai Yikui;Li Guanhong;Chen Jinxing;Shao Zhijun;Li Jianxiang;Veterinary Medicine Research Institute,Jiangxi New World Pharmaceutical Co Ltd;Institute of Animal Science, Jiangxi Academy of Agricultural Sciences;Ji'an Animal Husbandry and Veterinary Bureau;Jiangxi Agricultural University; 关键词：单味中兽药 ; 复方散剂 ; 超微粉碎 ; 小批量生产线 ; 工艺参数 英文关键词：Single TCVM;;Compound powder;;Ultrafine grinding;;Small batch production line;;Technology parameters 中文刊名：JLNK 英文刊名：Journal of Northeast Agricultural Sciences 机构：江西新天地药业有限公司兽药研究院;江西省农业科学院畜牧兽医研究所;吉安市畜牧兽医局;江西农业大学; 出版日期：2019-02-25 出版单位：东北农业科学 年：2019 期：v.44;No.215 基金：江西省重点研发计划项目(20132BBF60043);; 国家自然科学基金项目(31360563) 语种：中文; 页：JLNK201901009 页数：8 CN：01 ISSN：22-1376/S 分类号：38-45

摘要

中兽药超微粉碎不是以追求细度为目的,而是要求达到细胞级粉碎以将细胞破壁。本研究工艺采用自行组装的小型气流超微粉碎小批量生产线进行。试验用中兽药首先经预处理粉碎至120目以上、水分干燥至5%以下,然后再固定其它工艺参数,通过在50～70 Hz范围内调节分级筛工作频率及在-4～4℃范围内调节压缩空气温度来达到超微粉碎的目的。结果表明,单味中兽药青蒿、仙鹤草、何首乌、白头翁、肉桂及其复方散剂"鸡球虫散"经超微粉碎后:①粒径小,所测定的中心粒径(d50)依次为13.91μm、15.30μm、15.30μm、13.76μm、13.83μm及14.96μm,均接近千目12.5μm;②粒径分布均匀,所测定的粒径分布宽度(SPAN)依次为2.99、3.29、4.13、3.93、2.99及3.00,分布宽度小,并呈正态分布。光学显微镜观察发现本研究所用的中兽药超微粉看不到完整的细胞结构,只有细胞碎片,表明达到了细胞级粉碎。此外,经本工艺粉碎的单味中兽药超微粉及其复方混合中兽药超微粉的产品质量指标相似,今后可将各单味中兽药按处方要求配伍成复方散剂,再采用本工艺进行混合超微粉碎,以便进行工业化大生产。
        The ultrafine grinding of Traditional Chinese Veterinary Medicine(TCVM) is not in pursuit of fineness, but for the cell level ground with the cell wall broken. The trial was taken with self-assembly small-sized jet milling small batch production line. The TCVM, of which the fineness and moisture were larger then 120 mesh and less then 5% respectively after pretreatment, had been superfinely grinded into cell level ultramicro powder through adjusting the classifying screen working frequency ranged from50 to 70 Hz and compressed air temperature ranged from-4 to 4℃ in the condition of other processing parameters being constant. The results showed that: a. the ultrafine particle sizes of center(d50) of single Artemisiae Annuae Herba, Agrimoniae Herba, Polygoni Multiflori Radix, Pulsatillae Radix, Cinnamomi Cortex and their Compound Powder"Chicken Coccidiosis Powder" were 13.91μm, 15.30 μm, 15.30 μm,13.76 μm, 13.83 μm and 14.96 μm respectively, slightly exceeded 12.5μm(1000 mesh). b. the particle size distribution widths(SPAN) were respectively 2.99, 3.29, 4.13, 3.93, 2.99 and 3.00, and the SPAN was small, presented normal distribution and uniform. The optical microscopic observation showed that the ultrafine powder was in incomplete cell structure, only presented the cell debris. Furthermore, the ultrafine grinding parameters among single and compound powder of traditional Chinese veterinary medicine were similar, so the ultrafine grinding of compound powder can be used to facilitate industrial production.

引文

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