桂枝茯苓汤化裁联合缩宫素对于子宫复旧不全并恶露不尽的疗效观察

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英文篇名：Observation on Efficacy of Guizhi Fuling Decoction Combined with Oxytocin in the Treatment of Subinvolution of Uterus and Lochiorrhea 作者：袁亚楠 ; 聂金霞 ; 陈难 英文作者：Yuan Ya-nan;Nie Jin-xia;Chen Nan;Department of Obstetrics, Zhengzhou Maternal and Child Health Hospital; 关键词：子宫复旧不全 ; 恶露不绝 ; 桂枝茯苓汤 ; 缩宫素 英文关键词：Subinvolution of Uterus;;Lochiorrhea;;Guizhi Fuling Decoction;;Oxytocin 中文刊名：ZYYS 英文刊名：Chinese Journal of Rational Drug Use 机构：郑州市妇幼保健院产科; 出版日期：2019-01-01 出版单位：中国合理用药探索 年：2019 期：v.16;No.181 语种：中文; 页：ZYYS201901038 页数：5 CN：01 ISSN：10-1462/R 分类号：129-133

摘要

目的 :观察桂枝茯苓汤化裁联合缩宫素治疗子宫复旧不全并恶露不尽的临床疗效。方法 :选取2016年1月—2018年1月在本院分娩后子宫复旧不全并恶露不绝的126例患者作为观察对象,按随机数字表法分为对照组与观察组,各63例。对照组应用缩宫素(20 U,qd)治疗,观察组在对照组基础上联合应用桂枝茯苓汤化裁,1剂药入500 mL水煎至240 mL取汁,煎2次,早晚各温服240 mL,每日一剂,比较两组临床疗效,治疗后第1 d、第7 d时子宫下降幅度与恶露排出量的变化情况,观察两组治疗前、后血液流变学指标及临床症状体征的改善情况。结果 :观察组总有效率为87.30%,高于对照组的79.37%,差异有统计学意义(P <0.05);治疗后第7 d时两组子宫下降幅度与恶露排出量均较治疗后第1 d改善,且观察组优于对照组,差异有统计学意义(P <0.05);治疗后,两组全血黏度、血浆黏度与纤维蛋白原(FiB)均较治疗前降低,且观察组低于对照组,差异有统计学意义(P <0.05);观察组小腹疼痛缓解时间、子宫压痛缓解时间、腰腹坠胀缓解时间、血性恶露持续时间、恶露总持续时间、治疗后7 d宫体大小、宫腔积液量均小于对照组,差异有统计学意义(P <0.05)。结论 :桂枝茯苓汤化裁联合缩宫素治疗子宫复旧不全并恶露不绝的临床疗效显著,能够有效缩短治疗周期,促进患者尽早康复。
        Objective: To observe the clinical efficacy of guizhi fuling decoction combined with oxytocin in the treatment of subinvolution of uterus and lochiorrhea. Methods: 126 patients with subinvolution of uterus and lochiorrhea after delivery from January 2016 to January 2018 were selected as subjects investigated and divided into a control group and an observation group according to the random number table method, 63 cases in each group. The patients in the control group were treated with oxytocin(20 U, qd), and the patients in the observation group were treated with guizhi fuling decoction on the basis of the control group. One dose of medicine was added to 500 mL water to obtain 240 mL juice, decoction twice, and taken 240 mL when it was warm in morning and evening, one dose a day. The clinical efficacy and the changes in uterine descent amplitude and lochia volume discharged on the 1st and 7th day after treatment were compared between the two groups, and the improvement of hemorheological indexes and clinical symptoms and signs before and after treatment in the two groups were observed. Results: The total effective rate in the observation group was 87.30%, which was higher than 79.37% in the control group, with statistically significant difference(P<0.05).The uterine descent amplitude and lochia volume discharged on the 7th day after treatment were higher than those on the 1st day after treatment, and the indexes in the observation group were superior to those in the control group, with statistically significant differences(P<0.05). The whole blood viscosity, plasma viscosity and fibrinogen(FiB) after treatment were lower than those before treatment in the two groups, and the indexes in the observation group were lower than those in the control group, with statistically significant difference(P<0.05). The abdominal pain relief time, uterine tenderness relief time, waist and abdomen sagging distention relief time, bloody lochia duration, total lochia duration, uterine body size after 7 days of treatment and intrauterine fluid volume in the observation group were smaller than those in the control group, with statistically significant difference(P<0.05). Conclusion: The guizhi fuling decoction combined with oxytocin has significant clinical efficacy in the treatment of subinvolution of uterus and lochiorrhea, which can effectively shorten treatment cycles and promote the early recovery of the patients.

引文

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