帕罗西汀血药浓度检测方法研究进展
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摘要
帕罗西汀为5-羟色胺(5-HT)阻断药,具有起效快、疗效好、不良反应低等优点,为目前临床上常用抗抑郁症药物。帕罗西汀疗效和不良反应与该药血药浓度密切相关,并且个体差异性较大。因此,研究开发专一性强、灵敏度高的血药浓度检测方法十分必要,具有重要的临床和实践意义。本文综述帕罗西汀血药浓度检测时血样的前处理方法,同时对高效液相色谱法和气相色谱法检测帕罗西汀血药浓度进展进行论述,为该领域的临床合理用药和相关领域的研究提供借鉴。
Paroxetine, as the hydroxytryptamine(5-HT) uptake inhibitor with rapid efficacy, and low adverse reaction, is offen used as antidepressant clinically at present. The curative effect and adverse reaction of paroxetine are closely related to it's blood concentration, but the individual difference is obvious. Therefore, to research and development of medicine concentration in human plasma with high specificity and sensitivity is very necessary and has the important clinical and practical significance. In this article, we reviewed the development of the pretreatment methods of blood samples, as well as the high performance liquid chromatography and gas chromatography. The aim was to provide hints for clinical medicine use and researches of related fields.
Paroxetine, as the hydroxytryptamine(5-HT) uptake inhibitor with rapid efficacy, and low adverse reaction, is offen used as antidepressant clinically at present. The curative effect and adverse reaction of paroxetine are closely related to it's blood concentration, but the individual difference is obvious. Therefore, to research and development of medicine concentration in human plasma with high specificity and sensitivity is very necessary and has the important clinical and practical significance. In this article, we reviewed the development of the pretreatment methods of blood samples, as well as the high performance liquid chromatography and gas chromatography. The aim was to provide hints for clinical medicine use and researches of related fields.
引文
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[13]Zheng,M.-M.In-tube solid-phase microextraction based on hybrid silica monolith coupled to liquid chromatography-mass spectrometry for automated analysis of ten antidepressants in human urine and plasma[J].Journal of Chromatography A,2010,1217(48):7493-7501
[14]Porto,C.E.D.Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma[J].Quim Nova,2012,35(1):72-76
[15]Lai,C.-T.,Gordon,E.S.Kennedy,S.H,et al.Determination of paroxetine levels in human plasma using gas chromatography with electron-capture detection[J].J Chromatogr B Biomed Sci Appl,2000,749(2):275-279
[16]魻nal,A.and A.魻ztun觭.Determination of paroxetine in human plasma by high-performance liquid chromatography using 7,7,8,8-tetracyanoquinodimethane as the derivatization reagent[J].Ther Drug Monit,2006,28(2):180-184
[17]施爱明,王蒙,周文佳,等.盐酸帕罗西汀薄膜衣片的生物等效性研究[J].中国药学杂志,2012,47(05):367-370Shi Ai-ming,Wang Meng,Zhou Wen-jia,et al.Bioequivalence Study of Paroxetine Hydrochloride Film-Coated Tablets[J].Chinese Pharmaceutical Journal,2012,47(05):367-370
[18]Socala K,Nieoczym D,Wyska E,et al.Sildenafil,a phosphodiesterase type 5 inhibitor,reduces antidepressant-like activity of paroxetine in the forced swim test in mice[J].Pharmacol Rep,2012,64(5):1259-1266
[19]El-Nabarawi MA,Bendas ER,El Rehem RT,et al.Transdermal drug delivery of paroxetine through lipid-vesicular formulation to augment its bioavailability[J].Int J Pharm,2013,443(1-2):307-317
[20]文友民,魏世杰,党宏万,等.HPLC法同时测定人血浆中6种抗抑郁药的浓度[J].中国药房,2009,20(32):2506-2508Wen You-min,Wei Shi-jie,Dang Hong-wan,et al.Simultaneous Determination of 6 Antidepressants in Human Plasma by HPLC[J].China Ph armacy,2009,20(32):2506-2508
[21]刘亦伟,王长连,黄品芳.HPLC-ECD法测定小鼠血浆中异丙肾上腺素浓度[J].药物分析杂志,2011,31(6):1098-1101Liu Yi-wei,Wang Chang-lian,Huang Pin-fang.HPLC-ECD determination of isoproterenol concentration in mouse plasma[J].Chin J Pharm Anal,2011,31(6):1098-1101
[22]周桂云,陈平,孙秀丽,等.HPLC-ECD法测定盐酸大观霉素有关物质[J].药物分析杂志,2012,32(9):1665-1668Zhou Gui-yun,Chen Ping,Sun Xiu-li,et al.Determination of spectinomycin hydrochloride related substances by HPLC-ECD[J].Chin J Pharm Anal,2012,32(9):1665-1668
[23]刘亚妮,魏柳珍,于捷飞,等.气相色谱法同时测定无极膏中5个挥发性有效成分的含量[J].药物分析杂志,2012,32(3):406-409Liu Ya-ni,Wei Liu-zhen,Yu Jie-fei,et al.GC simultaneous determination of fivevolatile effective components in Compositus Mentholi cream[J].Chin J Pharm Anal,2012,32(3):406-409
[24]李艳,罗立骏,程辉跃,等.气相色谱法测定维生素E软胶囊含量的不确定度评定[J].药物分析杂志,2012,32(4):692-696Li Yan,Luo Li-jun,Cheng Hui-yue,et al.GC evaluation of measurement uncertainty for the determination of vitamin E soft cream[J].Chin J Pharm Anal,2012,32(4):692-696
[25]熊凤梅,唐玉海,孙四娟,等.毛细管电泳电化学发光法测定盐酸帕罗西汀的研究[J].分析试验室,2008,27(10):63-65Xiong Feng-mei,Tang Yu-hai,Sun Si-juan,et al.Study of capillary by electrophoresis electroch emiluminescence determination hydrochloride paroxetine[J].Chinese Journal of Analysis Laboratory,2008,27(10):63-65
[2]Van Zeeland YR,Schoemaker NJ,Haritova A,et al.Pharmacokinetics of paroxetine,a selective serotonin reuptake inhibitor,in Grey parrots(Psittacus erithacus erithacus):influence of pharmaceutical formulation and length of dosing[J].Vet Pharmacol Ther,2012,36(1):51-58
[3]隋玉辉.文拉法辛与帕罗西汀治疗抑郁症的临床疗效比较[J].中国医院用药评价与分析,2013,13(7):641-643Sui Yu-hui.Clinical Efficacy of Venlafaxine vs Paroxetine for Depression[J].Evaluation and analysis of drug-use in hospitals of China,2013,13(7):641-643
[4]陈川柏.帕罗西汀联合小剂量非典型抗精神病药物对老年抑郁症的临床疗效[J].中国老年学杂志,2013,33(13):3216-3217Chen Chuan-bo.Paroxetine combined with low-dose atypical antipsychotic drugs on the clinical efficacy of geriatric depression[J].Chinese Journal of Gerontology,2013,33(13):3216-3217
[5]孙静,赵汝松,王霞,等.液液萃取-HPLC-ESI-MS法同步测定环境水样中的三氯卡班和三氯生[J].山东轻工业学院学报(自然科学版),2011,25(1):35-37Sun Jing,Zhao Ru-song,Wang Xia,et al.Liquid-liquid extractionHPLC-ESI-MS method of simultaneous determination of environmental water samples triclocarban and triclosan[J].Journal of Shandong Polytecinic University(Natural Science Edition),2011,25(1):35-37
[6]张梨,谭群友,柳珊,等.液-液萃取反相离子对色谱法测定口腔崩解片剂中溴吡斯的明的血浆浓度[J].光谱实验室,2011,28(6):2753-2758Zhang Li,Tan Qun-you,Liu Shan et al.Liquid-liquid extraction phase ion pair chromatography orally disintegrating tablets pyridostigmine bromide plasma concentrations[J].Chinese Journal of Spectroscopy Laboratory,2011,28(6):2753-2758
[7]Tournel G,Houdret N,Hédouin V,et al.High-performance liquid chromatography method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum[J].J Chromatog B,2001,761(2):147-158
[8]Zainaghi,Lanchote,Queiroz.Determination of paroxetine in geriatric depression by high-performance liquid chromatography[J].Pharmacological research,2003,48(2):217-221
[9]张信凤,侯晓玲,黎薇,等.光度法及离子色谱法测定驱油剂中硫酸根含量-联合运用盐析法及活性炭吸附法除去其复杂有机物基体干扰[J].理化检验(化学分册),2011,47(08):882-884Zhang Xin-feng,Hou Xiao-ling,Li Wei,et al.Photometric and ion chromatographic determination of sulfate in deoiling agents with elimination of complex organic matrix interference by combined use of salting-out and active carbon adsorption[J].Physical Testing and Chemical Analysis Part B(Chemical Analysis),2011,47(08):882-884
[10]Juan,H.,et al.Simultaneous determination of fluoxetine,citalopram,paroxetine,venlafaxine in plasma by high performance liquid chromatography-electrospray ionization mass spectrometry(HPLCMS/ESI)[J].J Chromatography B,2005,820(1):33-39
[11]Konig S,Aebi B,Lanz S,et al.On-line SPE LC-MS/MS for the quantification of Delta9-tetrahydrocannabinol(THC)and its two major metabolites in human peripheral blood by liquid chromatography tandem mass spectrometry[J].Anal Bioanal Chem,2011,400(1):9-16
[12]Thibeault D,Caron N,Djiana R,et al.Development and optimization of simplified LC-MS/MS quantification of 25-hydroxyvitamin D using protein precipitation combined with on-line solid phase extraction(SPE)[J].J Chromatogr B Analyt Technol Biomed Life Sci,2011,883-884(2012):120-127
[13]Zheng,M.-M.In-tube solid-phase microextraction based on hybrid silica monolith coupled to liquid chromatography-mass spectrometry for automated analysis of ten antidepressants in human urine and plasma[J].Journal of Chromatography A,2010,1217(48):7493-7501
[14]Porto,C.E.D.Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma[J].Quim Nova,2012,35(1):72-76
[15]Lai,C.-T.,Gordon,E.S.Kennedy,S.H,et al.Determination of paroxetine levels in human plasma using gas chromatography with electron-capture detection[J].J Chromatogr B Biomed Sci Appl,2000,749(2):275-279
[16]魻nal,A.and A.魻ztun觭.Determination of paroxetine in human plasma by high-performance liquid chromatography using 7,7,8,8-tetracyanoquinodimethane as the derivatization reagent[J].Ther Drug Monit,2006,28(2):180-184
[17]施爱明,王蒙,周文佳,等.盐酸帕罗西汀薄膜衣片的生物等效性研究[J].中国药学杂志,2012,47(05):367-370Shi Ai-ming,Wang Meng,Zhou Wen-jia,et al.Bioequivalence Study of Paroxetine Hydrochloride Film-Coated Tablets[J].Chinese Pharmaceutical Journal,2012,47(05):367-370
[18]Socala K,Nieoczym D,Wyska E,et al.Sildenafil,a phosphodiesterase type 5 inhibitor,reduces antidepressant-like activity of paroxetine in the forced swim test in mice[J].Pharmacol Rep,2012,64(5):1259-1266
[19]El-Nabarawi MA,Bendas ER,El Rehem RT,et al.Transdermal drug delivery of paroxetine through lipid-vesicular formulation to augment its bioavailability[J].Int J Pharm,2013,443(1-2):307-317
[20]文友民,魏世杰,党宏万,等.HPLC法同时测定人血浆中6种抗抑郁药的浓度[J].中国药房,2009,20(32):2506-2508Wen You-min,Wei Shi-jie,Dang Hong-wan,et al.Simultaneous Determination of 6 Antidepressants in Human Plasma by HPLC[J].China Ph armacy,2009,20(32):2506-2508
[21]刘亦伟,王长连,黄品芳.HPLC-ECD法测定小鼠血浆中异丙肾上腺素浓度[J].药物分析杂志,2011,31(6):1098-1101Liu Yi-wei,Wang Chang-lian,Huang Pin-fang.HPLC-ECD determination of isoproterenol concentration in mouse plasma[J].Chin J Pharm Anal,2011,31(6):1098-1101
[22]周桂云,陈平,孙秀丽,等.HPLC-ECD法测定盐酸大观霉素有关物质[J].药物分析杂志,2012,32(9):1665-1668Zhou Gui-yun,Chen Ping,Sun Xiu-li,et al.Determination of spectinomycin hydrochloride related substances by HPLC-ECD[J].Chin J Pharm Anal,2012,32(9):1665-1668
[23]刘亚妮,魏柳珍,于捷飞,等.气相色谱法同时测定无极膏中5个挥发性有效成分的含量[J].药物分析杂志,2012,32(3):406-409Liu Ya-ni,Wei Liu-zhen,Yu Jie-fei,et al.GC simultaneous determination of fivevolatile effective components in Compositus Mentholi cream[J].Chin J Pharm Anal,2012,32(3):406-409
[24]李艳,罗立骏,程辉跃,等.气相色谱法测定维生素E软胶囊含量的不确定度评定[J].药物分析杂志,2012,32(4):692-696Li Yan,Luo Li-jun,Cheng Hui-yue,et al.GC evaluation of measurement uncertainty for the determination of vitamin E soft cream[J].Chin J Pharm Anal,2012,32(4):692-696
[25]熊凤梅,唐玉海,孙四娟,等.毛细管电泳电化学发光法测定盐酸帕罗西汀的研究[J].分析试验室,2008,27(10):63-65Xiong Feng-mei,Tang Yu-hai,Sun Si-juan,et al.Study of capillary by electrophoresis electroch emiluminescence determination hydrochloride paroxetine[J].Chinese Journal of Analysis Laboratory,2008,27(10):63-65