丹参素钠对2期压力性损伤模型大鼠受压部位病理学的影响
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摘要
<正>压力性损伤俗称压疮,是指皮肤和深部软组织由强烈和(或)长期的压力或压力联合剪切力所致的局部损伤。现代研究发现~([1-3]),丹参提取物丹参素钠有潜在的抗氧化、抑制炎症反应、促进血管内皮生长及创面修复等作用。笔者通过建立2期压力性损伤模型,观察丹参素钠对2期压力性损伤模型大鼠受压部位病理学的影响。1材料与方法1.1实验动物:SPF级健康雄性大鼠25只,月龄20～22
引文
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[2]Irmak F,Yazar S K,?irvan S S,et al.Beneficial effects of Salvia miltiorrhiza in the healing of burn wounds:an experimental study in rats[J].Journal of Plastic Surgery&Hand Surgery,2018,52(4):1-5.
[3]Yin Y,Duan J,Guo C,et al. Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis[J]. European Journal of Pharmacology,2017,814:274-282.
[4]张亚楠,李贤,严德云,等.构建各期大鼠压疮模型方法的实验研究[J].护理研究,2017,31(31):3945-3948.
[5]江仕爽,吴疆,王晓慧,等.两性离子水凝胶敷料用于压疮创面的实验研究[J].护理学杂志,2018,33(2):48-51.
[6]Ren Z,Li H,Zhang M,et al. A novel derivative of the natural product danshensu suppresses inflammatory responses to alleviate caerulein-induced acute pancreatitis[J].Front Immunol,2018,9:2513.
[7]Li Y,Shi S,Gao J,et al.Cryptotanshinone downregulates the profibrotic activities of hypertrophic scar fibroblasts and accelerates wound healing:A potential therapy for the reduction of skin scarring[J].Biomed Pharmacother,2016,80:80-86.