尿足细胞相关蛋白检测研究进展
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摘要
<正>肾小球是肾脏最重要的功能单位部分,它是由毛细血管内皮细胞、基底膜、脏层上皮细胞(足细胞)、系膜细胞及基质组成。其中前三者构成肾小球滤过膜,肾小球过滤的物质必须通过这3个结构才能从毛细血管腔进入Bowman’s囊。足细胞本身由胞体和足突组成,足突是胞体上大的突出部分,长长的足突黏附在肾小球基底膜上。足突有3个表面,分别是顶端、侧面和基底[1]。每个表面都有独特的功能和结构,当足细胞受损时,足细
引文
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[3]Konvalinka A,Scholey JW,Diamandis EP.Searching for new biomarkers of renal diseases through proteomics[J].Clin Chem,2012,58(2):353-365.
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[5]Okubo S.A study of urinary podocalyxin in children with Ig A nephropathy[J].Jap J Nephrol,1995,37(7):357-365.
[6]Tomino Y.Immunopathological predictors of prognosis in Ig A nephropathy[J].Contrib Nephrol,2013,181:65-74.
[7]Nakamura T,Ushiyama C,Suzukietal S.Urinary excretion of podocytes in patients with diabetic nephropathy[J].Nephrol Dial Transpl,2000,15(9):1379-1383.
[8]Ye H,Bai X,Gao H,et al.Urinary podocalyxin positive-element occurs in the early stage of diabetic nephropathy and is correlated with a clinical diagnosis of diabetic nephropathy[J].J Diabetes Complications,2014,28(1):96-100.
[9]Zhu B,Li XF,Zhu XL,et al.ELISA analysis of urinary nephrin and podocalyxin standardized by aquaporin-2 in adult patients with nephrotic syndrome[J].J Nephrol,2014,27(4):411-417.
[10]周晓菊,李宇宁.哺乳动物雷帕霉素靶蛋白在阿霉素诱导足细胞损伤中的作用[J].国际儿科学杂志,2014,41(6):644-648.
[11]Asao R,Asanuma K,Kodama F,et al.Relationships between levels of urinary podocalyxin,number of urinary podocytes,and histologic injury in adult patients with Ig A nephropathy[J].Clin J Am Soc Nephrol,2012,7(9):1385-1393.
[12]P?t?ri A,Forsblom C,Havana M,et al.Nephrinuria in diabetic nephropathy of type 1 diabetes[J].Diabetes,2003,52(12):2969-2974.
[13]Navarro-Munoz M,Ibernon M,Pérez V,et al.Messenger RNA expression of B7-1 and NPHS1 in urinary sediment could be useful to differentiate between minimal-change disease and focal segmental glomerulosclerosis in adult patients[J].Nephrol Dial Transplan,2011,26(12):3914-3923.
[14]Wang P,Li M,Liu Q,et al.Detection of urinary podocytes and nephrin as markers for children with glomerular diseases[J].Exp Biol Med,2015,240(2):169-174.
[15]Nakatsue T,Koike H,Han GD,et al.Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy[J].Kidney Int,2005,67(6):2239-2253.
[16]Petermann AT,Krofft R,Blonski M,et al.Podocytes that detach in experimental membranous nephropathy are viable[J].Kidney Int.,2003,64(4):1222-1231.
[17]Petermann AT,Pippin J,Krofft R,et al.Viable podocytes detach in experimental diabetic nephropathy:potential mechanism underlying glomerulosclerosis[J].Nephron Exp Nephrol,2004,98(4):114-123.
[18]Sato Y,Wharram BL,Lee SK,et al.Urine podocyte m RNAs mark progression of renal disease[J].J Am Soc Nephrol,2009,20(5):1041-1052.
[19]Fukuda A,Wickman LT,Venkatareddy MP,et al.Urine podocin:nephrin m RNA ratio(PNR)as a podocyte stress biomarker[J].Nephrol Dial Transplant,2012,27(11):4079-4087.
[20]Wang G,Lai FM-M,Tam L-S,et al.Messenger RNA expression of podocyte-associated molecules in urinary sediment of patients with lupus nephritis[J].J Rheumatol,2007,34(12):2358-2364.
[21]Zheng M,Lv L-L,Ni J,et al.Urinary podocyte-associated m RNA profile in various stages of diabetic nephropathy[J].PLo S ONE,2011,6(5):20431.
[22]Szeto C-C,Lai K-B,Chow K-M,et al.Messenger RNA expression of glomerular podocyte markers in the urinary sediment of acquired proteinuric diseases[J].Clin Chim Acta,2005,361(1-2):182-190.
[23]Sakairi T,Abe Y,Kajiyama H,et al.Conditionally immortalized human podocyte cell lines established from urine[J].Am J Physiol Renal Physiol,2010,298(3):557-567.
[24]Hara M,Yanagihara T,Itoh M,et al.Immunohistochemical and urinary markers of podocyte injury[J].Pediat Nephrol,1998,12(1):43-48.
[25]Murakoshi M,Tanimoto M,Gohda T,et al.Mindin:a novel marker for podocyte injury in diabetic nephropathy[J].Nephrol Dialysis Transpl,2011,26(7):2153-2160
[26]Rooney IA,Davies A,Griffiths D,et al.The complement-inhibiting protein,protectin(CD59 antigen),is present and functionally active on glomerular epithelial cells[J].Clin Exp Immunol,1991,83(2):251-256.
[27]Guo J-K,Menke AL,Gubler M-C,et al.WT1 is a key regulator of podocyte function:reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis[J].Hum Mol Genet,2002,11(6):651-659
[28]Batchelder CA,Lee CCI,Martinez ML,et al.Ontogeny of the kidney and renal developmental markers in the rhesus monkey(Macaca mulatta)[J].Anat Rec,2010,293(11):1971-1983.
[29]Ling C,Liu X,Shen Y,et al.Urinary CD80 levels as a diagnostic biomarker of minimal change disease[J].Pediatr Nephrol,2015,30(2):309-316.
[30]Nafar M,Kalantari S,Samavat S,et al.The novel diagnostic biomarkers for focal segmental glomerulosclerosis[J].Int J Nephrol,2014,2014:574261.
[31]Kalani A,Mohan A,Godbole MM,et al.Wilm’s tumor-1 protein levels in urinary exosomes from diabetic patients with or without proteinuria[J].PLo S One,2013,8(3):60177.
[2]Jefferson JA,Alpers CE,Shankland SJ.Podocyte biology for the bedside[J].Am J Kidney Dis,2011,58(5):835-845.
[3]Konvalinka A,Scholey JW,Diamandis EP.Searching for new biomarkers of renal diseases through proteomics[J].Clin Chem,2012,58(2):353-365.
[4]Hara M,Yanagihara T,Kihara I.Cumulative excretion of urinary podocytes reflects disease progression in Ig A nephropathy and Schonlein-Henoch¨purpura nephritis[J].Clin J Am Soc Nephrol,2007,2(2):231-238.
[5]Okubo S.A study of urinary podocalyxin in children with Ig A nephropathy[J].Jap J Nephrol,1995,37(7):357-365.
[6]Tomino Y.Immunopathological predictors of prognosis in Ig A nephropathy[J].Contrib Nephrol,2013,181:65-74.
[7]Nakamura T,Ushiyama C,Suzukietal S.Urinary excretion of podocytes in patients with diabetic nephropathy[J].Nephrol Dial Transpl,2000,15(9):1379-1383.
[8]Ye H,Bai X,Gao H,et al.Urinary podocalyxin positive-element occurs in the early stage of diabetic nephropathy and is correlated with a clinical diagnosis of diabetic nephropathy[J].J Diabetes Complications,2014,28(1):96-100.
[9]Zhu B,Li XF,Zhu XL,et al.ELISA analysis of urinary nephrin and podocalyxin standardized by aquaporin-2 in adult patients with nephrotic syndrome[J].J Nephrol,2014,27(4):411-417.
[10]周晓菊,李宇宁.哺乳动物雷帕霉素靶蛋白在阿霉素诱导足细胞损伤中的作用[J].国际儿科学杂志,2014,41(6):644-648.
[11]Asao R,Asanuma K,Kodama F,et al.Relationships between levels of urinary podocalyxin,number of urinary podocytes,and histologic injury in adult patients with Ig A nephropathy[J].Clin J Am Soc Nephrol,2012,7(9):1385-1393.
[12]P?t?ri A,Forsblom C,Havana M,et al.Nephrinuria in diabetic nephropathy of type 1 diabetes[J].Diabetes,2003,52(12):2969-2974.
[13]Navarro-Munoz M,Ibernon M,Pérez V,et al.Messenger RNA expression of B7-1 and NPHS1 in urinary sediment could be useful to differentiate between minimal-change disease and focal segmental glomerulosclerosis in adult patients[J].Nephrol Dial Transplan,2011,26(12):3914-3923.
[14]Wang P,Li M,Liu Q,et al.Detection of urinary podocytes and nephrin as markers for children with glomerular diseases[J].Exp Biol Med,2015,240(2):169-174.
[15]Nakatsue T,Koike H,Han GD,et al.Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy[J].Kidney Int,2005,67(6):2239-2253.
[16]Petermann AT,Krofft R,Blonski M,et al.Podocytes that detach in experimental membranous nephropathy are viable[J].Kidney Int.,2003,64(4):1222-1231.
[17]Petermann AT,Pippin J,Krofft R,et al.Viable podocytes detach in experimental diabetic nephropathy:potential mechanism underlying glomerulosclerosis[J].Nephron Exp Nephrol,2004,98(4):114-123.
[18]Sato Y,Wharram BL,Lee SK,et al.Urine podocyte m RNAs mark progression of renal disease[J].J Am Soc Nephrol,2009,20(5):1041-1052.
[19]Fukuda A,Wickman LT,Venkatareddy MP,et al.Urine podocin:nephrin m RNA ratio(PNR)as a podocyte stress biomarker[J].Nephrol Dial Transplant,2012,27(11):4079-4087.
[20]Wang G,Lai FM-M,Tam L-S,et al.Messenger RNA expression of podocyte-associated molecules in urinary sediment of patients with lupus nephritis[J].J Rheumatol,2007,34(12):2358-2364.
[21]Zheng M,Lv L-L,Ni J,et al.Urinary podocyte-associated m RNA profile in various stages of diabetic nephropathy[J].PLo S ONE,2011,6(5):20431.
[22]Szeto C-C,Lai K-B,Chow K-M,et al.Messenger RNA expression of glomerular podocyte markers in the urinary sediment of acquired proteinuric diseases[J].Clin Chim Acta,2005,361(1-2):182-190.
[23]Sakairi T,Abe Y,Kajiyama H,et al.Conditionally immortalized human podocyte cell lines established from urine[J].Am J Physiol Renal Physiol,2010,298(3):557-567.
[24]Hara M,Yanagihara T,Itoh M,et al.Immunohistochemical and urinary markers of podocyte injury[J].Pediat Nephrol,1998,12(1):43-48.
[25]Murakoshi M,Tanimoto M,Gohda T,et al.Mindin:a novel marker for podocyte injury in diabetic nephropathy[J].Nephrol Dialysis Transpl,2011,26(7):2153-2160
[26]Rooney IA,Davies A,Griffiths D,et al.The complement-inhibiting protein,protectin(CD59 antigen),is present and functionally active on glomerular epithelial cells[J].Clin Exp Immunol,1991,83(2):251-256.
[27]Guo J-K,Menke AL,Gubler M-C,et al.WT1 is a key regulator of podocyte function:reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis[J].Hum Mol Genet,2002,11(6):651-659
[28]Batchelder CA,Lee CCI,Martinez ML,et al.Ontogeny of the kidney and renal developmental markers in the rhesus monkey(Macaca mulatta)[J].Anat Rec,2010,293(11):1971-1983.
[29]Ling C,Liu X,Shen Y,et al.Urinary CD80 levels as a diagnostic biomarker of minimal change disease[J].Pediatr Nephrol,2015,30(2):309-316.
[30]Nafar M,Kalantari S,Samavat S,et al.The novel diagnostic biomarkers for focal segmental glomerulosclerosis[J].Int J Nephrol,2014,2014:574261.
[31]Kalani A,Mohan A,Godbole MM,et al.Wilm’s tumor-1 protein levels in urinary exosomes from diabetic patients with or without proteinuria[J].PLo S One,2013,8(3):60177.