一种毛细管电色谱整体柱的制备及其在CEC-MS中的应用

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英文篇名：Preparation and application of a new monolithic capillary column for enantioseparation by CEC-MS 作者：李英杰 ; 唐艺旻 ; 高立娣 ; 秦世丽 ; 刘树仁 ; 徐蕾 英文作者：LI Ying-jie;TANG Yi-min;GAO Li-di;QIN Shi-li;LIU Shu-ren;XU Lei;College of Chemistry and Chemical Engineering,Qiqihar University;Institute of Environmental Health,Zhejiang University; 关键词：阳离子型β-环糊精 ; 整体柱 ; 对映体拆分 ; 咪唑啉酮除草剂 ; 毛细管电色谱-质谱 英文关键词：cationic β-cyclodextrin;;monolithic column;;enantiomer separation;;imidazolinone herbicides;;capillary electrochromatography-mass spectrometry 中文刊名：HXYJ 英文刊名：Chemical Research and Application 机构：齐齐哈尔大学化学与化学工程学院;浙江大学环境与资源学院环境健康研究所; 出版日期：2019-03-15 出版单位：化学研究与应用 年：2019 期：v.31 基金：黑龙江省教育厅海外学人科研项目(1254HQ012)资助;黑龙江省教育厅基本业务专项理工面上项目(135209215)资助;; 黑龙江省自然科学基金项目(B2016009)资助 语种：中文; 页：HXYJ201903010 页数：5 CN：03 ISSN：51-1378/O6 分类号：69-73

摘要

本研究以烯丙基咪唑鎓β-环糊精(AI-β-CD)为功能单体,乙二醇二甲基丙烯酸酯(EDMA)为交联剂,采用原位聚合法制备了一种毛细管电色谱整体柱。优化制柱条件,通过红外光谱和扫描电镜对整体柱固定相的结构和形貌进行表征。以D,L-酪氨酸为分析物对整体柱性能进行评价。结果表明,所制备固定相成功键合到毛细管内,并形成错综复杂的网状结构。同时该整体柱具有较强的对映体分离能力及稳定性。应用毛细管电色谱与质谱联用技术对手性除草剂甲氧咪草烟对映体进行分离,分离度为2.25。
        In this study,a new monolithic capillary electrochromatography column wasprepared by one-step reaction with allylimidazolium-β-cyclodextrin(AI-β-CD)as functional monomer andethylene glycol dimethacrylate(EDMA)ascrosslinker.Moreover,the preparation conditions of the monolithic column were also optimized.The structure and morphology of the monolithic column were characterized by IR and SEM.The performance of monolithic column was evaluated by D,L-Tyr.The results show that the prepared stationary phase is successfully bonded into the capillary and forms a complex pore structure.Meanwhile,the capillary column exhibits anexcellent enantioseparation capability and stability.In the CEC-MS,the Imazamox enantiomers were separated and the resolution was 2.25.

引文

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