老鹰茶中一个新的木脂素
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摘要
采用硅胶、MCI、半制备高效液相色谱等柱色谱方法对贵州老鹰茶乙酸乙酯部位的化学成分进行分离纯化,根据NMR数据以及理化性质鉴定了化合物的结构,分离得到2个木脂素类化合物分别鉴定为老鹰茶木脂素A(1)和cinnamophilin (2)。化合物1为新化合物,化合物2为首次从该植物中分离得到。
The chemical constituents of Litsea coreana were investigated using chromatographic methods,including column chromatography on silica gel, MCI, and semi-preparation HPLC. Two compounds were isolated and identified as hawktealignan A(1) and cinnamophilin(2) by NMR analyses as well as their physical and chemical properties. Compound 1 is a new lignan and compound 2 was isolated from this plant for the first time.
The chemical constituents of Litsea coreana were investigated using chromatographic methods,including column chromatography on silica gel, MCI, and semi-preparation HPLC. Two compounds were isolated and identified as hawktealignan A(1) and cinnamophilin(2) by NMR analyses as well as their physical and chemical properties. Compound 1 is a new lignan and compound 2 was isolated from this plant for the first time.
引文
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[2]Shen JZ,Ye M,Shu AQ,et al.Extraction and purification of polyphenolic compounds and determination of EGCG from eagle tea(Litsea coreana Lévl.var.lanuginosa)[J].J Zhejiang Univ Agric Life Sci(浙江大学学报?农业与生命科学版),2010,36:329-334.
[3]Wang J,Lu WL,Zhang YL,et al.Chemical constituents from hawk tea[J].J Tianjin Med Univ(天津医科大学学报),2014,49:479-483.
[4]Xiao X,Pei Y,Xu LJ,et al.Study on the dynamic changes of the content of total flavonoids and total polyphenol and the antioxidant activity of Litsea coreana Levl.var.Lanuginosa[J].World Sci Technol/Mod Tradit Chin Med Mater Med(世界科学技术-中医药现代化),2015,17:603-608.
[5]Liu B.Simultaneous quantification of seven flavonoids in eagle tea using pressurized liquid extraction and HPLC[J].Chin JPharm Anal(药物分析杂志),2010,30:1424-1427.
[6]Chen YP,Cheng WM,Li J,et al.Analyse on the chemical constituents from flavonoids of Litsea coreana L[J].J Anhui Med Univ(安徽医科大学学报),2008,43:65-67.
[7]Ji HF,Nan HJ,Zhang LW,et al.Extraction and antioxidant properties of total flavonoids from Litsea coreana L[J].Chin Food Addit(中国食品添加剂),2008,43:65-67.
[8]Su G,Zhang R,Yang X,et al.Lignans from the stem bark of Syringa pinnatifolia[J].Fitoterapia,2016,114:63-68.
[9]Yang YN,Huang XY,Wang W,et al.A new neolignan from the fruits of Arctium lappa L[J].Acta Pharm Sin(药学学报),2017,52:779-784.
[10]Keun YJ,Dong SK,Sei RO,et al.Magnone A and B,novel antipaf tetrahydrofuran lignans from the flower buds of Magnolia fargesii[J].J Nat Prod,1998,61:808-811.
[11]Wang LN,Qin LL,He JL,et al.Aryl-tetralin-type lignan isolated from Sanguisorba officinalis[J].J Asian Nat Prod Res,2018,26:1-6.DOI:10.1080/10286020.2018.1487957.
[12]Wu TS,Leu YL,Chan YY,et al.Lignans and an aromatic acid from Cinnamomum philippinense[J].Pergamon,1994,36:785-788.