中西医结合治疗痛风急性发作
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摘要
目的观察痛风方联合塞来昔布治疗痛风急性发作(GA)的临床疗效。方法选取60例GA患者随机分为治疗组及对照组,各30例。对照组仅口服塞来昔布,治疗组在对照组的基础上加服痛风方。治疗7天后对比2组临床治疗情况。结果治疗组总有效率高于对照组(P <0.05);治疗组治疗后症状、体征评分、急性炎症指标下降均明显优于照组(P <0.01);治疗组BUA值下降指标优于对照组(P <0.05);复查ALT、AST、Scr、BUN等肝肾功能指标与治疗前比较无明显差异(P> 005)。结论中西医结合治疗痛风急性发作疗效好,可明显改善血液流变学指标,安全有效。
Objective To observe the clinical efficacy of Tongfeng Decoction combined with celecoxib capsules on acute gout attack. Methods 60 patients were randomly divided into treatment group and control group, 30 in each group. The control group was only administrated with celecoxib, and the treatment group was treated combined with Tongfeng Decoction. After 7 days of treatment, the efficacy was evaluated. Results The total effective rate of the treatment group was higher than that of the control group(P <0.05). The symptom, physical score and acute inflammation index of the treatment group were significantly better than those in the treatment group(P <0.01). Compared with the control group, the treatment group had better BUA value reduction index(P <0.05). The Safety indicator-ALT, AST, Scr and BUN were not significantly different from those before treatment(P >005). Conclusion Integrated traditional Chinese and western medicine has a good curative effect, and can significantly improve the hemorheology index, which is safe and effective and worthy of clinical promotion.
Objective To observe the clinical efficacy of Tongfeng Decoction combined with celecoxib capsules on acute gout attack. Methods 60 patients were randomly divided into treatment group and control group, 30 in each group. The control group was only administrated with celecoxib, and the treatment group was treated combined with Tongfeng Decoction. After 7 days of treatment, the efficacy was evaluated. Results The total effective rate of the treatment group was higher than that of the control group(P <0.05). The symptom, physical score and acute inflammation index of the treatment group were significantly better than those in the treatment group(P <0.01). Compared with the control group, the treatment group had better BUA value reduction index(P <0.05). The Safety indicator-ALT, AST, Scr and BUN were not significantly different from those before treatment(P >005). Conclusion Integrated traditional Chinese and western medicine has a good curative effect, and can significantly improve the hemorheology index, which is safe and effective and worthy of clinical promotion.
引文
[1]陈淑娇,李灿东.男性无症状高尿酸血症和痛风病患者中医体质类型分布及与肥胖关系比较研究[J].中华中医药杂志, 2013, 3(11):3174-3177.
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[11]杜明瑞,郭志忠.四妙散为主方治疗痛风性关节炎疗效与安全性的系统评[J].中国实验方剂学杂志, 2015, 5(13):212-216.
[12]赵岭梅.中药治疗高尿酸血症27例[J].中医杂志, 2007,48, 6(6):533-534.
[13]向黎黎.中药治疗痛风用药规律的文献研究[J].中医正骨,2015, 13(12):46-49.
[14]范海洲.山慈菇药理研究[J].湖北中医杂志, 2015, 8(2):74-75.
[15]刘友章.防己茯苓汤加减治疗痛风性关节炎疗效观察[J].现代中西医结合杂志, 2005, 11(15):1976-1977.
[16]吴霜霜,戚益铭.中药有效成分防治痛风性关节炎的研究进展[J].中国中医急症, 2015, 10(7):1215-1217.
[2]中华医学会风湿病学分会, 2016中国痛风诊疗指南[J].中华内科杂志, 2016, 12(11):892-899.
[3]曾学军.《2015年美国风湿病学会/欧洲抗风湿联盟痛风分类标准》解读[J].中华临床免疫和变态反应杂志, 2015,15(4):235-238.
[4]国家中医药管理局.中医病证诊断疗效标准[S].北京:中国医药科技出版社, 2012:46.
[5]郑筱萸.中药新药临床研究指导原则[S].北京:中国医药科技出版社, 1995:179-183.
[6]郭剑华,痛风消颗粒治疗急性痛风性关节炎临床观察[J].实用中医药杂志, 2017, 20(8):879-880.
[7]承良凤,陆进明.痛风药物治疗新进展[J].中国临床药理学与治疗学, 2015, 25(9):1066-1071.
[8]刘敏,项新.加味四妙汤联合塞来昔布治疗湿热蕴结型痛风疗效观察[J].现代中西医结合杂志, 2016, 15(34):3827-3828.
[9]李幼玲.四妙散加味治疗急性痛风性关节炎64例观察[J].现代临床医学, 2012, 20(2):113-114.
[10]王晓民,高学汉.自拟方治疗痛风性关节炎40例临床观察[J].吉林中医药, 2007, 13(2):26-27.
[11]杜明瑞,郭志忠.四妙散为主方治疗痛风性关节炎疗效与安全性的系统评[J].中国实验方剂学杂志, 2015, 5(13):212-216.
[12]赵岭梅.中药治疗高尿酸血症27例[J].中医杂志, 2007,48, 6(6):533-534.
[13]向黎黎.中药治疗痛风用药规律的文献研究[J].中医正骨,2015, 13(12):46-49.
[14]范海洲.山慈菇药理研究[J].湖北中医杂志, 2015, 8(2):74-75.
[15]刘友章.防己茯苓汤加减治疗痛风性关节炎疗效观察[J].现代中西医结合杂志, 2005, 11(15):1976-1977.
[16]吴霜霜,戚益铭.中药有效成分防治痛风性关节炎的研究进展[J].中国中医急症, 2015, 10(7):1215-1217.