自噬在肾缺血再灌注损伤中的研究进展
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摘要
自噬(autophagy)是一种进化上高度保守的过程,广泛存在于哺乳动物细胞内依赖溶酶体途径的降解方式。在细胞应激的情况下,如缺氧、营养剥夺、内质网应激、氧化还原损伤等,自噬溶酶体会降解受损的细胞器和大分子物质并合成新的物质供细胞再次利用,以此维持细胞稳态。本文就自噬及在肾脏缺血再灌注损伤中的作用及其机制进行综述。
Autophagy is an evolutionarily highly conserved process that resides extensively in the mammalian cell-dependent lysosome pathway.In the case of pathological damage such as hypoxia, nutrient deprivation, endoplasmic reticulum stress, and oxidative stress, damaged organelles and macromolecular substances will be degraded by autolysosomes to synthesize new substances for recycling, which is beneficial to maintain cell homeostasis.This article reviews the role and mechanisms of autophagy in renal ischemia reperfusion injury.
Autophagy is an evolutionarily highly conserved process that resides extensively in the mammalian cell-dependent lysosome pathway.In the case of pathological damage such as hypoxia, nutrient deprivation, endoplasmic reticulum stress, and oxidative stress, damaged organelles and macromolecular substances will be degraded by autolysosomes to synthesize new substances for recycling, which is beneficial to maintain cell homeostasis.This article reviews the role and mechanisms of autophagy in renal ischemia reperfusion injury.
引文
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[38]LIU Y,SHI B,LI Y,et al.Protective Effect of Luteolin Against Renal Ischemia/Reperfusion Injury via Modulation of ProInflammatory Cytokines,Oxidative Stress and Apoptosis for Possible Benefit in Kidney Transplant[J/OL].Med Sci Monit,2017,23:5720-5727.[2018-06-15].https://www.medscimonit.com/download/index/id Art/903253.DOI:10.12659/MSM.903253.
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[45]NAZIR S,GADI I,AL-DABET MM,et al.Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via m TORC1 inhibition[J].Blood,2017,130(24):2664-2677.
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[48]WANG L,CHEN Z,LIU Y,et al.Ozone oxidative postconditioning inhibits oxidative stress and apoptosis in renal ischemia and reperfusion injury through inhibition of MAPK signaling pathway[J/OL].Drug Des Devel Ther,2018,12:1293-1301.[2018-06-15].https://www.dovepress.com/ozone-oxidative-postconditioning-inhibits-oxidativestress-and-apoptos-peer-reviewed-article-DDDT.DOI:10.2147/DDDT.S164927.
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[2]ZHAO M,ZHOU Y,LIU S,et al.Control release of mitochondriatargeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury[J].Drug Deliv,2018,25(1):546-554.
[3]LI H,MA Y,CHEN B,et al.mi R-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/beta-catenins pathway[J/OL].E ur J Pharmacol,2018,831:20-27.[2018-06-15].https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(18)30257-7.DOI:10.1016/j.ejphar.2018.05.001.
[4]HU JB,LI SJ,KANG X Q,et al.CD44-targeted hyaluronic acidcurcumin prodrug protects renal tubular epithelial cell survival from oxidative stress damage[J/OL].Carbohydr Polym,2018,193:268-280.[2018-06-15].https://www.sciencedirect.com/science/article/pii/S0144861718303898?via%3Dihub.DOI:10.1016/j.carbpol.2018.04.011.
[5]LI X,ZHU G,GOU X,et al.Negative feedback loop of autophagy and endoplasmic reticulum stress in rapamycin protection against renal ischemia-reperfusion injury during initial reperfusion phase[J/OL].FASEB J,2018,892:1-32.[2018-06-15].https://www.fasebj.org/doi/abs/10.1096/fj.201800299R?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed.DOI:10.1096/fj.201800299R.
[6]ZHANG LX,ZHAO HJ,SUN DL,et al.Niclosamide attenuates inflammatory cytokines via the autophagy pathway leading to improved outcomes in renal ischemia/reperfusion injury[J].Mol Med Rep,2017,16(2):1810-1816.
[7]LING H,CHEN H,WEI M,et al.The Effect of Autophagy on Inflammation Cytokines in Renal Ischemia/Reperfusion Injury[J].Inflammation,2016,39(1):347-356.
[8]ZHANG YL,ZHANG J,CUI LY,et al.Autophagy activation attenuates renal ischemia-reperfusion injury in rats[J].Exp Biol Med(Maywood),2015,240(12):1590-1598.
[9]ASHFORD TP,PORTER KR.Cytoplasmic components in hepatic cell lysosomes[J/OL].J Cell Biol,1962,12:198-202.[2018-06-15].http://jcb.rupress.org/content/12/1/198.long.DOI:10.1083/jcb.12.1.198.
[10]DETER RL,BAUDHUIN P,De DUVE C.Participation of lysosomes in cellular autophagy induced in rat liver by glucagon[J].J Cell Biol,1967,35(2):C11-C16.
[11]LIANG XH,JACKSON S,SEAMAN M,et al.Induction of autophagy and inhibition of tumorigenesis by beclin 1[J].Nature,1999,402(6762):672-676.
[12]ZOU M,LU N,HU C,et al.Beclin 1-mediated autophagy in hepatocellular carcinoma cells:implication in anticancer efficiency of oroxylin A via inhibition of m TOR signaling[J].Cell Signal,2012,24(8):1722-1732.
[13]SUN T,LI X,ZHANG P,et al.Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth[J/O L].Nat Commun,2015,6:7215.[2018-06-15].https://www.nature.com/articles/ncomms8215.DOI:10.1038/ncomms8215.
[14]CHEN L,LIU D,ZHANG Y,et al.The autophagy molecule Beclin1 maintains persistent activity of NF-kappa B and Stat3 in HTLV-1-transformed T lymphocytes[J].Biochem Biophys Res Commun,2015,465(4):739-745.
[15]KAUSHAL GP,SHAH SV.Autophagy in acute kidney injury[J].Kidney Int,2016,89(4):779-791.
[16]LIU Y,LEVINE B.Autosis and autophagic cell death:the dark side of autophagy[J].Cell Death Differ,2015,22(3):367-376.
[17]PARZYCH KR,KLIONSKY DJ.An overview of autophagy:morphology,mechanism,and regulation[J].Antioxid Redox Signal,2014,20(3):460-473.
[18]MIJALJICA D,PRESCOTT M,DEVENISH RJ.Microautophagy in mammalian cells:revisiting a 40-year-old conundrum[J].Autophagy,2011,7(7):673-682.
[19]DICE JF.Peptide sequences that target cytosolic proteins for lysosomal proteolysis[J].Trends Biochem Sci,1990,15(8):305-309.
[20]RAVIKUMAR B,SARKAR S,DAVIES JE,et al.Regulation of mammalian autophagy in physiology and pathophysiology[J].Physiol Rev,2010,90(4):1383-1435.
[21]BLENIS J.TOR,the Gateway to Cellular Metabolism,Cell Growth,and Disease[J].Cell,2017,171(1):10-13.
[22]CHAN EY,LONGATTI A,MCKNIGHT NC,et al.Kinaseinactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism[J].Mol Cell Biol,2009,29(1):157-171.
[23]KIM J,KUNDU M,VIOLLET B,et al.AMPK and m TOR regulate autophagy through direct phosphorylation of Ulk1[J].Nat Cell Biol,2011,13(2):132-141.
[24]YANG Z,KLIONSKY DJ.Mammalian autophagy:core molecular machinery and signaling regulation[J].Curr Opin Cell Biol,2010,22(2):124-131.
[25]ROMANOV J,WALCZAK M,IBIRICU I,et al.Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation[J].EMBO J,2012,31(22):4304-4317.
[26]RUBINSZTEIN DC,SHPILKA T,ELAZAR Z.Mechanisms of autophagosome biogenesis[J].Curr Biol,2012,22(1):R29-R34.
[27]CARROLL B,MOHD-NAIM N,MAXIMIANO F,et al.The TBC/Rab GAP Armus coordinates Rac1 and Rab7 functions during autophagy[J].Dev Cell,2013,25(1):15-28.
[28]JAGER S,BUCCI C,TANIDA I,et al.Role for Rab7 in maturation of late autophagic vacuoles[J].J Cell Sci,2004,117(Pt 20):4837-4848.
[29]DERETICV,SAITOHT,AKIRAS.Autophagyininfection,inflammation and immunity[J].Nat Rev Immunol,2013,13(10):722-737.
[30]MURIACH M,FLORES-BELLVER M,ROMERO FJ,et al.Diabetes and the brain:oxidative stress,inflammation,and autophagy[J/OL].O xid Med Cell Longev,2014,2014:102158.[2018-06-15].https://www.hindawi.com/journals/omcl/2014/02158/.DOI:10.1155/2014/102158.
[31]NAVARRO-YEPES J,BURNS M,ANANDHAN A,et al.Oxidative stress,redox signaling,and autophagy:cell death versus survival[J].Antioxid Redox Signal,2014,21(1):66-85.
[32]FERNANDEZ A,ORDONEZ R,REITER RJ,et al.Melatonin and endoplasmic reticulum stress:relation to autophagy and apoptosis[J].J Pineal Res,2015,59(3):292-307.
[33]KAVVADAS P,KEUYLIAN Z,PRAKOURA N,et al.Notch3orchestrates epithelial and inflammatory responses to promote acute kidney injury[J/OL].Kidney Int,2018,94(1):126-138.[2018-06-15].https://www.sciencedirect.com/science/article/pii/S0085253818301807?via%3Dihub.DOI:10.1016/j.kint.2018.01.031.
[34]WANG Z,HAN Q,GUO YL,et al.Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation[J].Acta Cir Bras,2018,33(3):238-249.
[35]COOK DN,PISETSKY DS,SCHWARTZ DA.Toll-like receptors in the pathogenesis of human disease[J].Nat Immunol,2004,5(10):975-979.
[36]LAPAQUETTE P,GUZZO J,BRETILLON L,et al.Cellular and Molecular Connections between Autophagy and Inflammation[J/OL].Mediators Inflamm,2015,2015:398483.[2018-06-15].https://www.hindawi.com/journals/mi/2015/398483/.DOI:10.1155/2015/398483.
[37]BAO DS,WU YK,FU SJ,et al.Hyperbaric Oxygenation Protects Against Ischemia-Reperfusion Injury in Transplanted Rat Kidneys by Triggering Autophagy and Inhibiting Inflammatory Response[J/OL].Ann Transplant,2017,22:75-82.[2018-06-15].https://www.annalsoftransplantation.com/download/index/id Art/901102.DOI:10.12659/AOT.901102.
[38]LIU Y,SHI B,LI Y,et al.Protective Effect of Luteolin Against Renal Ischemia/Reperfusion Injury via Modulation of ProInflammatory Cytokines,Oxidative Stress and Apoptosis for Possible Benefit in Kidney Transplant[J/OL].Med Sci Monit,2017,23:5720-5727.[2018-06-15].https://www.medscimonit.com/download/index/id Art/903253.DOI:10.12659/MSM.903253.
[39]HARRIS J.Autophagy and cytokines[J].Cytokine,2011,56(2):140-144.
[40]QI Y,ZHANG M,LI H,et al.Autophagy inhibition by sustained overproduction of IL6 contributes to arsenic carcinogenesis[J].Cancer Res,2014,74(14):3740-3752.
[41]HARRIS J,HOPE JC,KEANE J.Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis[J].J Infect Dis,2008,198(12):1842-1850.
[42]LI X,YUN Z,TAN Z,et al.The role of Toll-like receptor(TLR)2and 9 in renal ischemia and reperfusion injury[J].Urology,2013,81(6):1315-1379.
[43]CHEN CB,LIU LS,ZHOU J,et al.Up-Regulation of HMGB1Exacerbates Renal Ischemia-Reperfusion Injury by Stimulating Inflammatory and Immune Responses through the TLR4 Signaling Pathway in Mice[J].Cell Physiol Biochem,2017,41(6):2447-2460.
[44]SHI CS,KEHRL JH.My D88 and Trif target Beclin 1 to trigger autophagy in macrophages[J].J Biol Che m,2008,283(48):33175-33182.
[45]NAZIR S,GADI I,AL-DABET MM,et al.Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via m TORC1 inhibition[J].Blood,2017,130(24):2664-2677.
[46]SHI CS,SHENDEROV K,HUANG NN,et al.Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction[J].Nat Immunol,2012,13(3):255-263.
[47]BODEMANN BO,ORVEDAHL A,CHENG T,et al.Ral B and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly[J].Cell,2011,144(2):253-267.
[48]WANG L,CHEN Z,LIU Y,et al.Ozone oxidative postconditioning inhibits oxidative stress and apoptosis in renal ischemia and reperfusion injury through inhibition of MAPK signaling pathway[J/OL].Drug Des Devel Ther,2018,12:1293-1301.[2018-06-15].https://www.dovepress.com/ozone-oxidative-postconditioning-inhibits-oxidativestress-and-apoptos-peer-reviewed-article-DDDT.DOI:10.2147/DDDT.S164927.
[49]孙小强.自噬在心肌缺血再灌注损伤中的研究进展[J].解放军预防医学杂志,2018(3):417-421.
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