中药对大肠埃希菌耐药性消除作用研究进展
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摘要
致病性大肠埃希菌的耐药性给人类健康及畜禽生产带来巨大威胁,这已引起国内外学者的广泛关注。中药可以通过多种途径消除细菌耐药性,研究中药消除致病性大肠埃希菌耐药性的作用效果及机制对保障人类健康和畜禽生产具有重要意义。论文对致病性大肠埃希菌的耐药现状、中药消除效果及作用机制的最新研究进展进行综述,以期为中药消除致病性大肠埃希菌耐药性提供科学依据。
The drug resistances of pathogenic Escherichia coli posess great threat to human health and livestock production,which has attracted wide attention from scholars both at home and abroad.Traditional Chinese medicines can eliminate bacterial resistance through many ways.The research on the effects and mechanisms of the elimination of drug resistance of pathogenic E.coli by Chinese medicines is of great significance to safeguard human health and livestock production.This paper summarized the latest research progresses in the status of drug resistance of pathogenic E.coli,the elimination effects of traditional Chinese medicines,and the mechanisms of action,to provide a theoretical basis for the elimination of drug resistance of pathogenic E.coli through traditional Chinese medicines.
The drug resistances of pathogenic Escherichia coli posess great threat to human health and livestock production,which has attracted wide attention from scholars both at home and abroad.Traditional Chinese medicines can eliminate bacterial resistance through many ways.The research on the effects and mechanisms of the elimination of drug resistance of pathogenic E.coli by Chinese medicines is of great significance to safeguard human health and livestock production.This paper summarized the latest research progresses in the status of drug resistance of pathogenic E.coli,the elimination effects of traditional Chinese medicines,and the mechanisms of action,to provide a theoretical basis for the elimination of drug resistance of pathogenic E.coli through traditional Chinese medicines.
引文
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[22]陈群,陈南菊,王胜春.黄连对大肠杆菌R质粒消除作用的实验研究[J].中国中西医结合杂志,1996,16(1):37-38.
[23]张石磊,翟向和,王春光,等.小檗碱对禽源大肠杆菌抑菌作用及耐药消除作用的转录组学分析[J].中国畜牧兽医,2017(5):1518-1525.
[24]芦亚君,程宁.3种中药方剂对大肠埃希菌超广谱β-内酰胺酶的抑制作用[J].中国医院药学杂志,2010(13):1097-1100.
[25]乐小丽,曾杨梅,陈红伟,等.粉防己提取液对大肠埃希菌AcrAB-TolC外排泵调控基因的影响研究[J].西南大学学报:自然科学版,2017(3):28-33.
[26]刘坤友,周艳,陈桂生,等.苦丁茶和小飞扬草对多重耐药性大肠杆菌外排泵acrA基因表达的影响[J].广西医学,2016(2):207-210.
[27]杭永付,薛晓燕,方芸,等.中药抗菌和逆转耐药作用机制研究进展[J].中国药房,2011(47):4504-4507.
[2]Qiao M,Ying G G,Singer A C,et al.Review of antibiotic resistance in China and its environment[J].Environ Int,2018,110:160-172.
[3]二十国集团领导人杭州峰会公报[J].中国经济周刊,2016(36):98-105.
[4]Zhang Y W,Gao F,Liu Y C,et al.Tetracycline sensitivity test and drug resistance gene detection of Escherichia coli in one chicken farm of Fuxin[J].Prog Vet Med,2017,38(10):118-121.
[5]刘正明,李金泉,黄德浩,等.内蒙古地区羊源大肠杆菌耐药性研究[J].中国畜牧兽医,2017,44(3):839-846.
[6]关淼,赵凤菊,赵晓彤,等.辽宁猪源大肠埃希菌的分离鉴定与药敏试验[J].动物医学进展,2017,38(2):132-136.
[7]于静晨,王虹,李鑫,等.53株禽致病性大肠杆菌的耐药表型及耐药基因的检测[J].畜牧与兽医,2017(5):134-141.
[8]Kumarasamy K K,Toleman M A,Walsh T R,et al.Emergence of a new antibiotic resistance mechanism in India,Pakistan,and the UK:a molecular,biological,and epi-demiological study[J].Lancet Infect Dis,2010,10(9):597-603.
[9]Schwarz S,Loeffler A,Kadlec K.Bacterial resistance to antimicrobial agents and its impact on veterinary and human medicine[A]//Advances in Veterinary Dermatology[M].John Wiley&Sons,Ltd,2017.
[10]张泽辉,宋雪娇,黄程程,等.细菌的获得性耐药机制研究进展[J].动物医学进展,2017,38(1):74-77.
[11]Harrison E,Brockhurst M A.Plasmid-mediated horizontal gene transfer is a coevolutionary process[J].Trend Microbiol,2012,20(6):262-267.
[12]邵莉萍,张继瑜.喹诺酮类药物的抗菌活性与细菌耐药性研究进展[J].中国畜牧兽医,2017,44(9):2773-2782.
[13]Singh S,Singh S K,Chowdhury I,et al.Understanding the mechanism of bacterial biofilms resistance to antimicrobial aagents[J].Open Microbiol J,2017,11(1):53-62.
[14]Ahmad I,Nawaz N,Dermani F K,et al.Bacterial multidrug efflux proteins:a major mechanism of antimicrobial resistance[J].Current Drug Targets,2018,19(9):1-13.
[15]Shrestha A,Bajracharya A M,Subedi H,et al.Multi-drug resistance and extended spectrum beta lactamase producing Gram negative bacteria from chicken meat in Bharatpur Metropolitan,Nepal[J].Bmc Res Notes,2017,10(1):574-578.
[16]赵秋云.中药对临床型奶牛乳房炎源大肠杆菌的体外抑制及耐药消除研究[D].陕西杨凌:西北农林科技大学,2017.
[17]高迎春,张传津,魏秀丽,等.地锦草等中药提取物对大肠杆菌耐药消除作用的初步研究[J].中国兽药杂志,2010,44(11):12-16.
[18]韦嫔,谭艾娟,吕世明,等.中药消除致病性大肠杆菌耐药性的研究[J].江苏农业科学,2017(11):127-129.
[19]刘金平,吕世明,谭艾娟,等.中药提取物恢复耐药大肠杆菌对氨基糖苷类药物敏感性的研究[J].畜牧与兽医,2018(3):107-111.
[20]曹敏.天然β-内酰胺酶抑制剂的筛选研究[D].贵州贵阳:贵州大学,2016.
[21]罗芬芳.黄藤素、没食子酸增加β-内酰胺类抗生素对产ES-BLs大肠埃希菌的敏感性及其作用机理初步探讨[D].江西南昌:江西农业大学,2013.
[22]陈群,陈南菊,王胜春.黄连对大肠杆菌R质粒消除作用的实验研究[J].中国中西医结合杂志,1996,16(1):37-38.
[23]张石磊,翟向和,王春光,等.小檗碱对禽源大肠杆菌抑菌作用及耐药消除作用的转录组学分析[J].中国畜牧兽医,2017(5):1518-1525.
[24]芦亚君,程宁.3种中药方剂对大肠埃希菌超广谱β-内酰胺酶的抑制作用[J].中国医院药学杂志,2010(13):1097-1100.
[25]乐小丽,曾杨梅,陈红伟,等.粉防己提取液对大肠埃希菌AcrAB-TolC外排泵调控基因的影响研究[J].西南大学学报:自然科学版,2017(3):28-33.
[26]刘坤友,周艳,陈桂生,等.苦丁茶和小飞扬草对多重耐药性大肠杆菌外排泵acrA基因表达的影响[J].广西医学,2016(2):207-210.
[27]杭永付,薛晓燕,方芸,等.中药抗菌和逆转耐药作用机制研究进展[J].中国药房,2011(47):4504-4507.