大柴胡汤联合五苓散治疗肥胖型糖尿病的临床效果
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摘要
目的探讨大柴胡汤联合五苓散治疗肥胖型糖尿病的临床效果。方法选取2017年4月～2018年4月我院收治的40例肥胖型糖尿病患者作为研究对象,按照随机数字分配法将其分为实验组(20例)和对照组(20例)。实验组患者采用大柴胡汤联合五苓散方法 ,对照组患者采用口服二甲双胍肠溶片,0.5 g/次,每日3次。比较两组患者的临床疗效、体重指数(BMI)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)以及糖化血红蛋白(HbA1c)水平。结果实验组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组患者的BMI、FPG、2 h PG、HbA1c水平低于治疗前,FINS水平高于治疗前,差异均有统计学意义(P<0.05);治疗后,实验组患者的BMI、FPG、2 h PG、HbA1c水平低于对照组,FINS水平高于对照组,差异均有统计学意义(P<0.05)。结论大柴胡汤合五苓散治疗肥胖型糖尿病患者的临床效果显著,能缓解临床症状,下调BMI,纠正患者体内糖代谢紊乱,适宜临床应用。
Objective To explore the clinical effect of Dachaihu Decoction combined with Wuling Powder in the treatment of obese type diabetes mellitus. Methods A total of 40 obese patients with diabetes mellitus admitted from April 2017 to April 2018 treated in our hospital were selected as subjects and divided into experimental group(20 cases) and control group(20 cases) according to random number distribution method. The experimental group was treated with Dachaihu Decoction combined with Wuling Powder, while the control group was treated with Metformin Enteric-coated Tablets, 0.5 g each time, three times a day. The clinical efficacy, body mass index(BMI), the levels of fasting bloodglucose(FPG), blood-glucose 2 h after meal(2 h PG), fasting insulin(FINS) and glycosylated hemoglobin(HbA1c) were compared between the two groups. Results The total effective rate of treatment in the experimental group was higher than that in the control group, and the difference was statistically significant(P<0.05). After treatment, BMI,FPG, 2 h PG and HbA1c levels of the two groups were lower than those before treatment, and FINS levels were higher than that before treatment, and the differences were statistically significant(P<0.05). After treatment, BMI, FPG, 2 h PG and HbA1c levels of the experimental group were lower than those of the control group, and FINS levels were higher than those of the control group, with statistically significant differences(P<0.05). Conclusion Dachaihu Decoction and Wuling Powder are effective in the treatment of obese type diabetes mellitus, which can relieve clinical symptoms,reduce BMI and correct the disorder of glucose metabolism in patients with obese diabetes mellitus. It is suitable for clinical application.
Objective To explore the clinical effect of Dachaihu Decoction combined with Wuling Powder in the treatment of obese type diabetes mellitus. Methods A total of 40 obese patients with diabetes mellitus admitted from April 2017 to April 2018 treated in our hospital were selected as subjects and divided into experimental group(20 cases) and control group(20 cases) according to random number distribution method. The experimental group was treated with Dachaihu Decoction combined with Wuling Powder, while the control group was treated with Metformin Enteric-coated Tablets, 0.5 g each time, three times a day. The clinical efficacy, body mass index(BMI), the levels of fasting bloodglucose(FPG), blood-glucose 2 h after meal(2 h PG), fasting insulin(FINS) and glycosylated hemoglobin(HbA1c) were compared between the two groups. Results The total effective rate of treatment in the experimental group was higher than that in the control group, and the difference was statistically significant(P<0.05). After treatment, BMI,FPG, 2 h PG and HbA1c levels of the two groups were lower than those before treatment, and FINS levels were higher than that before treatment, and the differences were statistically significant(P<0.05). After treatment, BMI, FPG, 2 h PG and HbA1c levels of the experimental group were lower than those of the control group, and FINS levels were higher than those of the control group, with statistically significant differences(P<0.05). Conclusion Dachaihu Decoction and Wuling Powder are effective in the treatment of obese type diabetes mellitus, which can relieve clinical symptoms,reduce BMI and correct the disorder of glucose metabolism in patients with obese diabetes mellitus. It is suitable for clinical application.
引文
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[10]朱巍,高秀莹,郭彩红,等.艾塞那肽对肥胖及超重的中青年2型糖尿病患者体质量、血糖、血脂及蛋白尿的影响[J].中国药师,2017,20(5):842-845.
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[12]杨秀萍.中西药联合治疗2型糖尿病合并超重或肥胖患者19例[J].光明中医,2017,32(17):2544-2546.
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[16]陈晓辉,石鹤峰.五苓散加味联合盐酸二甲双胍片治疗肥胖型2型糖尿病40例[J].中医研究,2012,25(4):26-27.
[17]张北平,翟淑萍,苑伟,等.茵陈蒿汤联合加味大柴胡汤对肝缺血再灌注损伤大鼠的影响[J].中国医药导报,2018,15(30):21-24.
[18]乔莉,郑慧,杨丽霞,等.基于CNKI数据挖掘分析黄芪多糖治疗糖尿病的文献特征和研究现状[J].西部中医药,2017,30(3):56-59.
[2]王丽芹,李振南,隋博文.2型糖尿病的中医药研究进展[J].中医药信息,2017,34(3):121-124.
[3]周均.胰岛素强化和口服降糖药物治疗对新诊断2型糖尿病患者血糖控制及胰岛功能的影响比较[J].世界临床医学,2017,11(24):36.
[4]尚祥岭.健脾降糖汤治疗肥胖型2型糖尿病痰瘀气虚证临床研究[J].中医学报,2017,32(5):743-746.
[5]卫生部疾病控制司.《中国糖尿病防治指南》(试行本)(节选)[J].中国慢性病预防与控制,2004,12(6):283-285.
[6]中华人民共和国卫生部疾病控制司.中国成人超重和肥胖症预防控制指南[M].北京:人民卫生出版社,2006:61-62.
[7]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:51-52.
[8]申香莲.五苓散加减联合瑞格列奈治疗肥胖型2型糖尿病疗效观察[J].现代中西医结合杂志,2016,25(13):1425-1427.
[9]袁虹,朱小燕,陈凌云,等.探讨大柴胡汤加味联合盐酸二甲双胍肠溶胶囊用于2型糖尿病患者治疗中的临床效果[J].医学信息,2016,29(16):412.
[10]朱巍,高秀莹,郭彩红,等.艾塞那肽对肥胖及超重的中青年2型糖尿病患者体质量、血糖、血脂及蛋白尿的影响[J].中国药师,2017,20(5):842-845.
[11]陈瑞贞,黄湘霞,黄佩民.二甲双胍联合阿卡波糖对2型糖尿病患者脂联素的影响[J].深圳中西医结合杂志,2017,27(2):136-137.
[12]杨秀萍.中西药联合治疗2型糖尿病合并超重或肥胖患者19例[J].光明中医,2017,32(17):2544-2546.
[13]阳柳平.研究白术的化学成分及药理作用概况[J].中国医药指南,2012,10(21):607-609.
[14]刘明晖,赵树华.五苓散治疗慢性心力衰竭60例[J].西部中医药,2017,30(2):74-75.
[15]田婷,陈华,冯亚龙,等.泽泻药理与毒理作用的研究进展[J].中药材,2014,37(11):2103-2108.
[16]陈晓辉,石鹤峰.五苓散加味联合盐酸二甲双胍片治疗肥胖型2型糖尿病40例[J].中医研究,2012,25(4):26-27.
[17]张北平,翟淑萍,苑伟,等.茵陈蒿汤联合加味大柴胡汤对肝缺血再灌注损伤大鼠的影响[J].中国医药导报,2018,15(30):21-24.
[18]乔莉,郑慧,杨丽霞,等.基于CNKI数据挖掘分析黄芪多糖治疗糖尿病的文献特征和研究现状[J].西部中医药,2017,30(3):56-59.