茜芷胶囊联合妇科千金胶囊治疗IUD置入后阴道异常出血的临床观察
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摘要
目的观察茜芷胶囊联合妇科千金胶囊用于治疗IUD置入后阴道异常出血的临床疗效。方法以2016年2月—2018年2月象山县计划生育指导站收治的135例IUD置入后阴道异常出血患者为研究对象,按随机数字表法分为对照组、研究组1和研究组2,每组各45例。对照组不予以药物治疗,研究组1予以宫血宁胶囊口服治疗,研究组2予以茜芷胶囊联合妇科千金胶囊口服治疗。比较各组患者治疗前后血红蛋白和血清TNF-α、IL-6和IL-8含量,记录治疗期间药物不良反应,观察阴道异常出血改善和IUD因症取出情况。结果研究组2治疗后血清TNF-α、IL-6和IL-8含量均显著低于研究组1和对照组水平(均P<0.05),血红蛋白含量显著高于研究组1和对照组水平(均P<0.05),行经时间显著短于研究组1和对照组水平,月经出血量显著少于研究组1和对照组水平(均P<0.05);研究组1和研究组2阴道异常出血改善率(100.00%和97.78%)均显著高于对照组水平(80.00%),均P<0.05,且IUD因症取出率(0.00%和2.22%)均显著低于对照组水平(20.00%),均P<0.05;各组药物不良反应总体发生率差异无统计学意义(P>0.05)。结论茜芷胶囊联合妇科千金胶囊可显著降低IUD置入后阴道异常出血患者炎症反应强度,提高血红蛋白含量,缩短症状改善周期,提高患者IUD续用率,且未增加药物不良反应发生率。
Objective To observe on the clinical effect of Qianzhi capsule combined with Gynecological Qianjin capsule on the treatment of abnormal vaginal bleeding after IUD implantation. Methods A total of 135 patients with abnormal vaginal bleeding after IUD implantation were researched from February 2016 to February 2018. All the patients were divided into the control group(n=45), the study group 1(n=45) and the study group 2(n=45). The control group were not given medication. The study group 1 were given Gongxuening capsule orally. The study group 2 were given Qianzhi capsule and Gynecological Qianjin capsule orally. The levels of hemoglobin and serum TNF-α, IL-6 and IL-8 were compared between the different groups before and after treatment. The adverse drug reactions during treatment were recorded and the improvement of abnormal vaginal bleeding and the removal of IUD were observed. Results The serum levels of TNF-α, IL-6 and IL-8 in study group 2 were significantly lower than those in study group 1 and control group after treatment(P<0.05). The level of hemoglobin in study group 2 was significantly higher than those in study group 1 and control group after treatment(P<0.05). After treatment, the duration of menstruation was significantly shorter than those of study group 1 and control group, and the amount of menstrual bleeding was significantly less than those of study group 2 and control group(P<0.05). The improvement rates of abnormal vaginal bleeding(100.00% and 97.78%) in study group 1 and study group 2 were significantly higher than that in control group(80.00%), P<0.05, and the removal rate of IUD(0.00% and 2.22%) was significantly lower than that in control group(20.00%), P<0.05. There was no significant difference in the overall incidence of adverse drug reactions among the groups(P>0.05). Conclusion Qianzhi capsule combined with Gynecological Qianjin capsule can significantly reduce the intensity of inflammation in patients with abnormal vaginal bleeding after IUD implantation, increase the content of hemoglobin, shorten the improvement cycle of abnormal vaginal bleeding symptoms, improve the continuation rate of patients with IUD, and do not increase adverse drug reactions.
Objective To observe on the clinical effect of Qianzhi capsule combined with Gynecological Qianjin capsule on the treatment of abnormal vaginal bleeding after IUD implantation. Methods A total of 135 patients with abnormal vaginal bleeding after IUD implantation were researched from February 2016 to February 2018. All the patients were divided into the control group(n=45), the study group 1(n=45) and the study group 2(n=45). The control group were not given medication. The study group 1 were given Gongxuening capsule orally. The study group 2 were given Qianzhi capsule and Gynecological Qianjin capsule orally. The levels of hemoglobin and serum TNF-α, IL-6 and IL-8 were compared between the different groups before and after treatment. The adverse drug reactions during treatment were recorded and the improvement of abnormal vaginal bleeding and the removal of IUD were observed. Results The serum levels of TNF-α, IL-6 and IL-8 in study group 2 were significantly lower than those in study group 1 and control group after treatment(P<0.05). The level of hemoglobin in study group 2 was significantly higher than those in study group 1 and control group after treatment(P<0.05). After treatment, the duration of menstruation was significantly shorter than those of study group 1 and control group, and the amount of menstrual bleeding was significantly less than those of study group 2 and control group(P<0.05). The improvement rates of abnormal vaginal bleeding(100.00% and 97.78%) in study group 1 and study group 2 were significantly higher than that in control group(80.00%), P<0.05, and the removal rate of IUD(0.00% and 2.22%) was significantly lower than that in control group(20.00%), P<0.05. There was no significant difference in the overall incidence of adverse drug reactions among the groups(P>0.05). Conclusion Qianzhi capsule combined with Gynecological Qianjin capsule can significantly reduce the intensity of inflammation in patients with abnormal vaginal bleeding after IUD implantation, increase the content of hemoglobin, shorten the improvement cycle of abnormal vaginal bleeding symptoms, improve the continuation rate of patients with IUD, and do not increase adverse drug reactions.
引文
[1] 武向飞,黎荔.妇女宫内节育器放置的影响因素及研究进展[J].中国妇幼保健,2016,31(10):2237-2239.
[2] 尤爱霞,邓志凤.对人工流产的患者实施计划生育服务指导教育的临床效果分析[J].中华全科医学,2018,16(1):100-102.
[3] 赵英珍,任舒展.初产妇产后避孕知识及避孕措施落实情况分析[J].中国计划生育学杂志,2017,25(12):877-879.
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[7] 校林姣,李晶,崔瑜,等.元宫Cu365型与花式HCu280型宫内节育器的效果及不良反应分析[J].中国妇幼保健,2017,32(12):2709-2712.
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[9] 毛京沭,宗占红,舒星宇,等.我国农村中老年妇女生殖保健现状研究[J].中华全科医学,2015,13(10):1673-1674,1677.
[10] 李彦楠,李盼盼,张芳,等.宫宁颗粒治疗宫内节育器出血不良反应临床疗效及对子宫内膜形态学影响[J].中华中医药学刊,2018,36(5):1135-1138.
[11] 樊阳阳,宋宇龙,胡盈,等.致康胶囊治疗节育器致异常出血105例[J].中国药业,2015,24(18):111-112.
[12] 黄华清.宫血宁防治宫内节育器致不规则阴道流血的临床观察[J].广西中医药大学学报,2014,17(4):38-39.
[13] 刘福先.妇科千金胶囊联合屈螺酮炔雌醇片对人工流产术后阴道出血及子宫内膜修复的影响[J].现代中西医结合杂志,2017,26(23):2543-2545.
[14] 梁秀文,季新梅,吴琼,等.茜芷胶囊联合米非司酮治疗人流术后持续阴道出血的疗效观察[J].现代药物与临床,2017,32(4):678-681.
[15] 王明仙.茜芷胶囊联合妇科千金胶囊治疗放置宫内节育器后阴道出血的临床效果[J].实用妇科内分泌杂志(电子版),2018,5(33):100-102.
[2] 尤爱霞,邓志凤.对人工流产的患者实施计划生育服务指导教育的临床效果分析[J].中华全科医学,2018,16(1):100-102.
[3] 赵英珍,任舒展.初产妇产后避孕知识及避孕措施落实情况分析[J].中国计划生育学杂志,2017,25(12):877-879.
[4] 刘江坤,周瑞争,张素芝,等.河北省12775例宫内节育器不良反应发生情况及影响因素调查[J].中国妇幼保健,2015,30(8):1226-1229.
[5] 陶翼琛.中西医结合治疗放置宫内节育器后月经过多的疗效观察[J].浙江中医杂志,2015,50(11):827-828.
[6] 罗忠琛,赵娟娟,高玲玲.意外妊娠人工流产女性长效可逆避孕知识知晓现况及其影响因素研究[J].中国全科医学,2018,21(3):306-312.
[7] 校林姣,李晶,崔瑜,等.元宫Cu365型与花式HCu280型宫内节育器的效果及不良反应分析[J].中国妇幼保健,2017,32(12):2709-2712.
[8] 胡丽芳.宫内节育器不良反应调查及相关应对策略[J].中国妇幼保健,2018,33(2):394-397.
[9] 毛京沭,宗占红,舒星宇,等.我国农村中老年妇女生殖保健现状研究[J].中华全科医学,2015,13(10):1673-1674,1677.
[10] 李彦楠,李盼盼,张芳,等.宫宁颗粒治疗宫内节育器出血不良反应临床疗效及对子宫内膜形态学影响[J].中华中医药学刊,2018,36(5):1135-1138.
[11] 樊阳阳,宋宇龙,胡盈,等.致康胶囊治疗节育器致异常出血105例[J].中国药业,2015,24(18):111-112.
[12] 黄华清.宫血宁防治宫内节育器致不规则阴道流血的临床观察[J].广西中医药大学学报,2014,17(4):38-39.
[13] 刘福先.妇科千金胶囊联合屈螺酮炔雌醇片对人工流产术后阴道出血及子宫内膜修复的影响[J].现代中西医结合杂志,2017,26(23):2543-2545.
[14] 梁秀文,季新梅,吴琼,等.茜芷胶囊联合米非司酮治疗人流术后持续阴道出血的疗效观察[J].现代药物与临床,2017,32(4):678-681.
[15] 王明仙.茜芷胶囊联合妇科千金胶囊治疗放置宫内节育器后阴道出血的临床效果[J].实用妇科内分泌杂志(电子版),2018,5(33):100-102.
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