头孢噻肟钠和头孢唑肟钠治疗小儿急性肠系膜淋巴结炎的效果对比
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摘要
目的研究头孢噻肟钠和头孢唑肟钠治疗小儿急性肠系膜淋巴结炎的优劣差异。方法选取我院儿科2015年4月～2018年1月收治的104例小儿急性肠系膜淋巴结炎患者,随机分为实验组(n=52)和对照组(n=52)。实验组予头孢噻肟钠治疗,对照组予头孢唑肟钠治疗,比较两组的治疗效果、症状消退情况、肠系膜淋巴结、平均住院时间和医药费用。结果两组患者治疗3 d后的总有效率比较,差异无统计学意义(P>0.05)。实验组治疗1周后的总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗1周后的发热、呕吐、腹痛、腹泻、纳差等临床症状皆较治疗前好转(P<0.05),两组间比较差异无统计学意义(P>0.05)。两组治疗3 d及1周后的淋巴结肿大与内部血供异常比率皆较治疗前显著下降,差异有统计学意义(P<0.05)。两组治疗3 d及1周后的淋巴结肿大与内部血供异常比率比较,差异均无统计学意义(P>0.05)。实验组的住院时间显著短于对照组,医药费显著低于对照组,差异有统计学意义(P<0.05)。结论头孢噻肟钠与头孢唑肟钠均可有效治疗小儿急性肠系膜淋巴结炎,但头孢噻肟钠的长期治愈率较高,所需时间较少,医药费较低,值得临床推广。
Objective To study the difference between Cefotaxime Sodium and Ceftizoxime Sodium in the treatment of children with acute mesenteric lymphadenitis. Methods A total of 104 children with acute mesenteric lymphadenitis who were admitted to deparement of pediatrics in our hospital from April 2015 to January 2018 were selected and randomly divided into the experimental group(n=52) and the control group(n=52). The experimental group was treated with Cefotaxime Sodium, and the control group was given Ceftizoxime Sodium. The efficacy, symptom regression,mesenteric lymph nodes, average length of stay, and medical costs were compared between the two groups. Results There was no significant difference in the total effective rate between the two groups after 3 days of treatment(P>0.05).After 1 week of treatment, the total effective rate of the experimental group was greater than that of the control group(P <0.05). The clinical symptoms of fever, vomiting, abdominal pain, diarrhea, and anorexia in the two groups after 1 week of treatment were better than those before treatment(P<0.05), there was no significant difference between the two groups(P>0.05). The ratio of lymph node enlargement and internal blood supply abnormality in the two groups after 3 days and 1 week of treatment was statistically lower than that before treatment, with significant difference(P <0.05).And there was no significant difference in the ratio of lymph node enlargement to internal blood supply abnormality between the two groups after 3 days and 1 week(P>0.05). The hospital stay in the experimental group was shorter than that in the control group, and the medical expenses in the experimental group was lower than that in the control group,with significant differences(P<0.05). Conclusion Both Cefotaxime Sodium and Ceftizoxime Sodium are effective to cure children with acute mesenteric lymphadenitis, but Cefotaxime Sodium has higher long-term cure rate, less time required, and low medical expenses, it is worthy of clinical promotion.
Objective To study the difference between Cefotaxime Sodium and Ceftizoxime Sodium in the treatment of children with acute mesenteric lymphadenitis. Methods A total of 104 children with acute mesenteric lymphadenitis who were admitted to deparement of pediatrics in our hospital from April 2015 to January 2018 were selected and randomly divided into the experimental group(n=52) and the control group(n=52). The experimental group was treated with Cefotaxime Sodium, and the control group was given Ceftizoxime Sodium. The efficacy, symptom regression,mesenteric lymph nodes, average length of stay, and medical costs were compared between the two groups. Results There was no significant difference in the total effective rate between the two groups after 3 days of treatment(P>0.05).After 1 week of treatment, the total effective rate of the experimental group was greater than that of the control group(P <0.05). The clinical symptoms of fever, vomiting, abdominal pain, diarrhea, and anorexia in the two groups after 1 week of treatment were better than those before treatment(P<0.05), there was no significant difference between the two groups(P>0.05). The ratio of lymph node enlargement and internal blood supply abnormality in the two groups after 3 days and 1 week of treatment was statistically lower than that before treatment, with significant difference(P <0.05).And there was no significant difference in the ratio of lymph node enlargement to internal blood supply abnormality between the two groups after 3 days and 1 week(P>0.05). The hospital stay in the experimental group was shorter than that in the control group, and the medical expenses in the experimental group was lower than that in the control group,with significant differences(P<0.05). Conclusion Both Cefotaxime Sodium and Ceftizoxime Sodium are effective to cure children with acute mesenteric lymphadenitis, but Cefotaxime Sodium has higher long-term cure rate, less time required, and low medical expenses, it is worthy of clinical promotion.
引文
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[11]王秀芳.理气逐瘀汤加减治疗小儿肠系膜淋巴结炎[J].中医临床研究,2014,6(32):109-110.
[12]齐玉红.小儿急性肠系膜淋巴结炎103例诊治分析[J].医药前沿,2014,(26):133-134.
[13]陈琳琳.头孢哌酮舒巴坦治疗小儿急性肠系膜淋巴结炎的临床分析[J].中国医药指南,2016,14(13):177.
[14]吴熙金.小儿肠系膜淋巴结炎的诊治分析[J].当代医学,2014,20(30):69.
[15]徐学磊.双术汤对肠系膜淋巴结炎患儿临床疗效的观察[D].南宁:广西中医药大学,2017.
[2]张伟,赵凯赫,段晓征.小儿肠系膜淋巴结炎中西医研究进展[J].中国中医药现代远程教育,2017,15(13):158-160.
[3]刘方,李永超.头孢噻肟钠治疗急性肠系膜淋巴结炎患儿的临床疗效[J].中国中西医结合消化杂志,2016,24(7):555-557.
[4]胡亚美,江载芳.诸福棠实用儿科学[M].7版.北京:人民卫生出版社,2002:1362.
[5]刘传双,于兵.小儿急性肠系膜淋巴结炎高频超声诊断分析[J].中国医药指南,2016,10(1):12-14.
[6]邓芙蓉,王昭霞,赵玉新.热毒宁注射液治疗小儿急性肠系膜淋巴结炎疗效观察[J].基层医学论坛, 2017,19(27):3780-3781.
[7]李萍,赵海鑫,郭安爽.小儿急性肠系膜淋巴结炎腹痛中西医结合治疗的护理[J].天津护理,2017,25(2):145-146.
[8]杨莉萍,周高东.蒲地蓝消炎口服液联合头孢噻肟钠治疗急性肠系膜淋巴结炎的临床研究[J].现代药物与临床,2017,32(10):1939-1941.
[9]岳上赛,荣昊.中医医治疗小儿肠系膜淋巴结炎研究进展[J].中医临床研究,2017,9(17):138-140.
[10]唐晴.小儿肠系膜淋巴结炎临床特点及治疗体会[J].临床医药文献电子杂志,2016,3(24):4779-4780.
[11]王秀芳.理气逐瘀汤加减治疗小儿肠系膜淋巴结炎[J].中医临床研究,2014,6(32):109-110.
[12]齐玉红.小儿急性肠系膜淋巴结炎103例诊治分析[J].医药前沿,2014,(26):133-134.
[13]陈琳琳.头孢哌酮舒巴坦治疗小儿急性肠系膜淋巴结炎的临床分析[J].中国医药指南,2016,14(13):177.
[14]吴熙金.小儿肠系膜淋巴结炎的诊治分析[J].当代医学,2014,20(30):69.
[15]徐学磊.双术汤对肠系膜淋巴结炎患儿临床疗效的观察[D].南宁:广西中医药大学,2017.