高尿酸血症和痛风的高危因素分析
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摘要
目的探究与分析高尿酸血症及痛风的高危因素相关性分析。方法选取安徽中医药大学第一附属医院自2015年4月～2017年4月收治的90例高尿酸血症患者与90例痛风患者,分别作为高尿酸血症组和痛风组,采用Logistic多因素回归模型分析痛风的发生与肥胖、肝功能、血脂等因素的相关性。结果与高尿酸组比较,痛风组男性患者比例较高,总胆固醇≥5.72 mmol/L、三酰甘油(TG)≥1.71 mmol/L患者比例较高,高密度脂蛋白胆固醇<0.91 mmol/L患者比例较高,低密度脂蛋白胆固醇(LDL-C)≥3.37 mmol/L患者比例较高,载脂蛋白B≥1.20 g/L患者比例较高,谷丙转氨酶≥50 U/L患者比例较高,差异有统计学意义(P <0.05)。两组患者体重指数及载脂蛋白A水平比较,差异无统计学意义(P> 0.05)。将上述因素用Logistic多因素回归分析,可见男性、TG≥1.71 mmol/L、LDL-C≥3.37 mmol/L能够作为引起痛风的高危险因素(OR=2.05、2.45、3.12)。结论男性可作为痛风的主要发病人群,高TG、LDL-C可作为引起痛风的高危因素。
Objective To explore and analyze the correlation between high risk factors of hyperuricemia and gout.Methods From April 2015 to April 2017, 90 cases of hyperuricemia patients and 90 cases of gout patients admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were selected as the hyperuricemia group and the gout group respectively, Logistic multivariate regression model was used to analyze the correlation between the occurrence of gout and obesity, liver function, blood lipid and other factors. Results Compared with the high uric acid group, the gout group had a higher proportion of male patients, higher proportion of patients with total cholesterol ≥5.72 mmol/L and triglycerin(TG) ≥1.71 mmol/L, and higher proportion of patients with high density lipoprotein cholesterol <0.91 mmol/L. The proportion of patients with low-density lipoprotein cholesterol(LDL-C) ≥3.37 mmol/L,apolipoprotein B ≥1.20 g/L and alanine aminotransferase ≥50 U/L was higher, and the difference were statistically significant(P < 0.05). There was no significant difference in BMI and apolipoprotein A levels between the two groups(P > 0.05). The above factors were analyzed by Logistic multivariate regression, and it was found that male, TG ≥1.71 mmol/L, and LDL-C≥3.37 mmol/L could be considered as high risk factors for gout(OR = 2.05, 2.45, 3.12, respectively). Conclusion Men can be the main morbidity group of gout, and high TG and LDL-C can be the high risk factors of gout.
Objective To explore and analyze the correlation between high risk factors of hyperuricemia and gout.Methods From April 2015 to April 2017, 90 cases of hyperuricemia patients and 90 cases of gout patients admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were selected as the hyperuricemia group and the gout group respectively, Logistic multivariate regression model was used to analyze the correlation between the occurrence of gout and obesity, liver function, blood lipid and other factors. Results Compared with the high uric acid group, the gout group had a higher proportion of male patients, higher proportion of patients with total cholesterol ≥5.72 mmol/L and triglycerin(TG) ≥1.71 mmol/L, and higher proportion of patients with high density lipoprotein cholesterol <0.91 mmol/L. The proportion of patients with low-density lipoprotein cholesterol(LDL-C) ≥3.37 mmol/L,apolipoprotein B ≥1.20 g/L and alanine aminotransferase ≥50 U/L was higher, and the difference were statistically significant(P < 0.05). There was no significant difference in BMI and apolipoprotein A levels between the two groups(P > 0.05). The above factors were analyzed by Logistic multivariate regression, and it was found that male, TG ≥1.71 mmol/L, and LDL-C≥3.37 mmol/L could be considered as high risk factors for gout(OR = 2.05, 2.45, 3.12, respectively). Conclusion Men can be the main morbidity group of gout, and high TG and LDL-C can be the high risk factors of gout.
引文
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[11]王占成,阮长武,姬文慧,等.无症状高尿酸血症与高血压关系的临床研究[J].医学综述,2013,19(23):4367-4368.
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[13]杨丽辉,宋嘉,石荔,等.拉萨市区成年人高尿酸血症和痛风的流行病学调查[J].西部医学,2015,27(10):1467-1468.
[14]Dalbeth N,House ME,Gamble GD,et al.Populationspecific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load[J].Ann Rheum Dis,2013,72(11):1868-1873.
[15]宋薇.高尿酸血症和痛风的流行病学及影响因素研究进展[J].江西医药,2013,48(5):123-124.
[16]Li Z,Ding H,Chen C,et al.Novel URAT1 mutations caused acute renal failure after exercise in two Chinese families with renal hypouricemia[J].Gene,2013,512(1):97-101.
[17]Zhou D,Liu Y,Zhang X,et al.Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male population[J].Int J Mol Sci,2014,15(5):9149-9159.
[18]关宝生,白雪,王艳秋,等.痛风/高尿酸血症患者生活习惯的危险因素[J].中国老年学,2014,34(2):455-456.
[19]Xiong A,Yao Q,He J,et al.No causal effect of serum urate on bone-related outcomes among a population of postmenopausal women and elderly men of Chinese Han ethnicity-a mendelian randomization study[J].Osteoporos Int,2016,27(3):1031-1039.
[20]孙莹,陆萍静,牛海,等.西藏地区诱发高尿酸血症和痛风的危险因素研究[J].护理研究,2018,32(4):10-11.
[2]Leiba A,Vinker S,Dinour D,et al.Uric acid levels within the normal range predict increased risk of hypertension:Acohort study[J].J Am Soc Hypertens,2015,9(8):600-609
[3]郑淑瑛,周建平,胡瑜,等.模块式护理计划对痛风患者疼痛及生活质量的影响[J].中华现代护理杂志,2014,20(17):2077-2079.
[4]Qin L,Yang Z,Gu H,et al.Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals[J].BMC Cardiovasc Disord,2014,9(20):2235-2261.
[5]武广晔,田亚琼,黄娅,等.脑梗死患者血尿酸与血脂及颈动脉斑块形成的关系[J].中国实验诊断学,2014,18(8):1247-1248.
[6]雍雪莲,叶勇.某高校大学新生入学健康体检血尿酸检测结果分析[J].中国学校卫生,2014,35(9):1430-1431.
[7]Rodenbach KE,Schneider MF,Furth SL,et al.Hyperuricemia and progression of CKD in children and adolescents:The chronic kidney disease in children(CKiD)cohort study[J].Am J Kidney Dis,2015,66(6):984-992.
[8]柳旭,刘琼玲,万崇华.痛风病人生命质量量表研究现状[J].护理研究,2016,30(7C):2561-2562.
[9]Ciarla S,Struglia M,Giorgini P,et al.Serum uric acid levels and metabolic syndrome[J].Arch Physiol Biochem,2014,120(3):119-122.
[10]赵冰,聂庆东,屈飞飞,等.青年无症状高尿酸血症和血脂相关性研究[J].中国实验诊断学,2016,20(9):10-11.
[11]王占成,阮长武,姬文慧,等.无症状高尿酸血症与高血压关系的临床研究[J].医学综述,2013,19(23):4367-4368.
[12]Kottgen A,Albrecht E,Teumer A,et al.Genome-wide association analyses identify 18 new loci associated with serum urate concentrations[J].Nat Genet,2013,45(2):145-154.
[13]杨丽辉,宋嘉,石荔,等.拉萨市区成年人高尿酸血症和痛风的流行病学调查[J].西部医学,2015,27(10):1467-1468.
[14]Dalbeth N,House ME,Gamble GD,et al.Populationspecific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load[J].Ann Rheum Dis,2013,72(11):1868-1873.
[15]宋薇.高尿酸血症和痛风的流行病学及影响因素研究进展[J].江西医药,2013,48(5):123-124.
[16]Li Z,Ding H,Chen C,et al.Novel URAT1 mutations caused acute renal failure after exercise in two Chinese families with renal hypouricemia[J].Gene,2013,512(1):97-101.
[17]Zhou D,Liu Y,Zhang X,et al.Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male population[J].Int J Mol Sci,2014,15(5):9149-9159.
[18]关宝生,白雪,王艳秋,等.痛风/高尿酸血症患者生活习惯的危险因素[J].中国老年学,2014,34(2):455-456.
[19]Xiong A,Yao Q,He J,et al.No causal effect of serum urate on bone-related outcomes among a population of postmenopausal women and elderly men of Chinese Han ethnicity-a mendelian randomization study[J].Osteoporos Int,2016,27(3):1031-1039.
[20]孙莹,陆萍静,牛海,等.西藏地区诱发高尿酸血症和痛风的危险因素研究[J].护理研究,2018,32(4):10-11.