复合中药凝胶剂的制备
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摘要
本试验以天葵子为主药,与蒲公英、苦参、白鲜皮3种中药联合使用制备复方中药凝胶剂。采用水提法提取中药的有效成分,以卡波姆-940、主药、甘油、氮酮的用量为因素,采用正交试验设计,优选复合中药凝胶剂的最佳配比,并根据2015版中国药典关于凝胶剂的质量要求,对本试验所制备的复合中药凝胶剂进行质量检查。结果显示,1.5%卡波姆940,15%主药,10%甘油,1.5%氮酮为本试验中复合中药凝胶剂的最佳组合方案。药效学试验表明,本试验所制得的凝胶剂对治疗皮肤炎症具有一定的治疗效果。
In this experiment, the compound Chinese traditional Chinese medicine gel was prepared with three kinds of traditional Chinese medicine, including dandelion, bitter ginseng and pericarp. After extracting the effective ingredients of Chinese medicine by using the water extraction method, the optimum ratio of the main matrix of the compound gel was selected by the orthogonal test design with the factors of the amount of carbomer 940, the main drug, glycerin and azone, and the gel agent prepared in the 2015 edition of the Chinese Pharmacopoeia of the Chinese Pharmacopoeia was tested. The results showed that 1.5% of the main drug, 10% of the main drug, 10% glycerine, and 1.5% of azone were the best combination for the compound Chinese medicine gel. The pharmacodynamic test showed that the gel prepared by this experiment had certain therapeutic effect on inflammation.
In this experiment, the compound Chinese traditional Chinese medicine gel was prepared with three kinds of traditional Chinese medicine, including dandelion, bitter ginseng and pericarp. After extracting the effective ingredients of Chinese medicine by using the water extraction method, the optimum ratio of the main matrix of the compound gel was selected by the orthogonal test design with the factors of the amount of carbomer 940, the main drug, glycerin and azone, and the gel agent prepared in the 2015 edition of the Chinese Pharmacopoeia of the Chinese Pharmacopoeia was tested. The results showed that 1.5% of the main drug, 10% of the main drug, 10% glycerine, and 1.5% of azone were the best combination for the compound Chinese medicine gel. The pharmacodynamic test showed that the gel prepared by this experiment had certain therapeutic effect on inflammation.
引文
[1] 徐冉,肖海涛,王建塔,等.天葵化学成分及其药理作用研究进展[J].中国药业,2010,19(21):7-8.
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[3] 韩玲.中药外用制剂改剂型需“量体裁衣”[N].中国医药报,2008-12-11.
[4] 卢丰.浅谈凝胶剂在中药制剂中的研究进展[J].中国中医药现代远程教育,2012,19(17):162-164.
[5] 国家兽药典委员会.中华人民共和国兽药典.2015版.[S].北京:中国农业出版社,2015:附录9.
[6] 方和桂.适用于中药外用的剂型[J].凝胶剂医药专论,2002,11(8):25.
[7] 王曙东,刘文雅.凝胶剂的研究进展及应用概况[J].中国药业,2010,19(21):1-3.
[8] 王淑华,林永强.水性凝胶剂的制备及常用辅料[J].食品与药品,2006,8(2):55-57.
[9] Rhee Y S,Jung G,Park E S,et al.Transdermal delivery of ketoprofen using microemulsions[J].Int.J.Pharm,2001,228:161-170.
[10] 郭红叶,伊博文,闫小平,等.新型辅料卡波姆在凝胶剂中应用现状[J].中国试验方剂学杂志,2013,19(17):371-374.
[11] 王敏,薛晓东.卡波姆凝胶剂的临床应用研究进展[J].医学综述,2013,19(6):1-2.
[2] 罗开梅,黄轶群,张国广,等.紫背天葵提取物的抑菌活性研究[J].漳州师范学院学报(自然科学版),2011,24(4):83-86.
[3] 韩玲.中药外用制剂改剂型需“量体裁衣”[N].中国医药报,2008-12-11.
[4] 卢丰.浅谈凝胶剂在中药制剂中的研究进展[J].中国中医药现代远程教育,2012,19(17):162-164.
[5] 国家兽药典委员会.中华人民共和国兽药典.2015版.[S].北京:中国农业出版社,2015:附录9.
[6] 方和桂.适用于中药外用的剂型[J].凝胶剂医药专论,2002,11(8):25.
[7] 王曙东,刘文雅.凝胶剂的研究进展及应用概况[J].中国药业,2010,19(21):1-3.
[8] 王淑华,林永强.水性凝胶剂的制备及常用辅料[J].食品与药品,2006,8(2):55-57.
[9] Rhee Y S,Jung G,Park E S,et al.Transdermal delivery of ketoprofen using microemulsions[J].Int.J.Pharm,2001,228:161-170.
[10] 郭红叶,伊博文,闫小平,等.新型辅料卡波姆在凝胶剂中应用现状[J].中国试验方剂学杂志,2013,19(17):371-374.
[11] 王敏,薛晓东.卡波姆凝胶剂的临床应用研究进展[J].医学综述,2013,19(6):1-2.