鲁桑枝中黄酮类成分研究

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英文篇名：Flavonoids from twigs of Morus multicaulis 作者：钟雪敏 ; 黄晓君 ; 陈凌云 ; 沈梅 ; 石俊敏 ; 贺丽苹 ; 韩伟立 英文作者：ZHONG Xue-min;HUANG Xiao-jun;CHEN Ling-yun;SHEN Mei;SHI Jun-min;HE Li-ping;HAN Wei-li;Guangdong Key Laboratory of Tropical Disease Research, Department of inspection and quarantine, School of Public Health,Southern Medical University;Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University;Central Laboratory, Southern Medical University;Instrumental Analysis & Research Center, South China Agricultural University; 关键词：鲁桑 ; 黄酮 ; 桑枝酮A ; 圆二色谱 ; 补骨脂乙素 ; 异甘草素 英文关键词：Morus multicaulis Perr.;;flavonoid;;moritwigsone A;;electronic circular dichroism;;isobavachalcone;;isoliquiritigenin 中文刊名：ZCYO 英文刊名：Chinese Traditional and Herbal Drugs 机构：南方医科大学公共卫生学院卫生检测中心广东省热带病研究重点实验室;暨南大学药学院中药及天然药物研究所;南方医科大学中心实验室;华南农业大学测试中心; 出版日期：2019-04-28 出版单位：中草药 年：2019 期：v.50;No.643 基金：广东省自然科学基金项目(2016A030313541);; 南方医科大学公卫学院院长基金项目(GW201832) 语种：中文; 页：ZCYO201908018 页数：4 CN：08 ISSN：12-1108/R 分类号：159-162

摘要

目的研究鲁桑Morus multicaulis枝中的化学成分。方法采用多种色谱技术进行分离纯化,通过理化性质和波谱学数据对其进行结构鉴定。结果从鲁桑枝90%乙醇提取物中得到6个黄酮类成分,分别鉴定为桑枝酮A(1)、carpachromene(2)、补骨脂乙素(3)、异甘草素(4)、芹菜素(5)和槲皮素(6),其中化合物1的绝对构型通过圆二色谱量子化学计算得到了确定。结论化合物1为新化合物,命名为桑枝酮A,化合物2～4为首次从该植物中分离得到。
        Objective To investigate the chemical compounds from the twigs of Morus multicaulis. Methods The chemical constituents were isolated by various chromatographic methods from 90% ethanol aqueous extract of M. multicaulis and the structures were elucidated by a combined analysis of physicochemical properties, as well as spectroscopic methods including UV, IR, MS ECD and NMR. Results Six flavonoids were isolated and the structures were identified as moritwigsone A(1), carpachromene(2), isobavachalcone(3), isoliquiritigenin(4), apigenin(5), and quercitrin(6). The absolute configuration of compound 1 was determined by electronic circular dichroism(ECD) calculation. Conclusion Compound 1 is a new compound, named moritwigsone A, and compounds 2—4 are isolated from this plant for the first time.

引文

[1]国家中医药管理局《中华本草》编委会.中华本草(第2卷)[M].上海:上海科学出版社,1999.
    [2]Hnk T,Nguyen V T,Kim J A,et al.Anti-inflammatory activities of compounds from twigs of Morus alba[J].Fitoterapia,2017,120:17-24.
    [3]艾文,何厚洪,杜昕,等.桑枝化学成分的研究[J].中成药,2017,39(9):1861-1866.
    [4]陈震,汪仁芸,朱丽莲,等.桑枝水提取物化学成分的研究[J].中草药,2000,31(7):24-25.
    [5]许延兰,李续娥,邹宇晓,等.广东桑枝的化学成分研究[J].中国中药杂志,2008,33(21):2499-2502.
    [6]Wang M,Gao L X,Wang J,et al.Diels-Alder adducts with PTP1B inhibition from Morus notabilis[J].Phytochemistry,2015,109:140-146.
    [7]Xu L J,Yu M H,Huang C Y,et al.Isoprenylated flavonoids from Morus nigra and their PPARγagonistic activities[J].Fitoterapia,2018,127:109-114.
    [8]NavrátilováA,Schneiderov?K,Vesel?D,et al.Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity[J].Phytochemistry,2013,89(3):104-113.
    [9]宋敬丽,高慧,袁林,等.大叶藤黄化学成分研究[J].安徽农业科学,2015,43(32):222-224.
    [10]Pistelli L,Spera K,Flamini G,et al.Isoflavonoids and chalcones from Anthyllis hermanniae[J].Phytochemistry,1996,42(5):1455-1458.
    [11]何轶,鲁静,林瑞超.板蓝根化学成分研究[J].中草药,2003,34(9):777-778.
    [12]张红伟,张琳,孙晓飞,等.垫状卷柏化学成分研究[J].亚太传统医药,2008,4(6):36-37.
    [13]于德泉,杨峻山.分析化学手册(第7分册)[M].第2版.北京:化学工业出版社,1999.