盐酸替罗非班用于急性心肌梗死介入治疗对左室射血分数、肌酸磷酸激酶同工酶的影响
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摘要
目的观察盐酸替罗非班用于急性心肌梗死(AMI)介入治疗对左室射血分数、肌酸磷酸激酶同工酶的影响。方法将86例AMI介入治疗患者随机分为两组,对照组42例直接实施介入治疗,观察组44例先应用替罗非班氯化钠注射液,之后实施介入治疗,比较两组治疗效果、治疗后左室射血分数及肌酸磷酸激酶同工酶变化情况。结果观察组治疗后即刻TIMI血流3级者比例明显高于对照组(P<0.05);治疗后12 h观察组肌酸磷酸激酶同工酶水平明显低于对照组(P<0.05),治疗后1周观察组左室射血分数明显高于对照组。随访显示,1个月内观察组不良心脏事件发生率2.27%明显低于对照组的19.05%(P<0.05)。结论盐酸替罗非班氯化钠注射液用于AMI介入治疗,可有效改善患者血流情况,提高左室射血分数,降低肌酸磷酸激酶同工酶水平,且可降低心脏不良事件发生风险。
Objective To analyze the effects of tirofiban hydrochloride sodium chloride injection on left ventricular ejection fraction(LVEF)and creatine phosphokinase isoenzyme(CK)in patients with acute myocardial infarction(AMI).Methods 86 patients with AMI were randomly divided into two groups:the control group(n= 42)received direct interventional therapy,and the observation group(n= 44)were treated with tirofiban first and then interventional therapy.Changes of left ventricular ejection fraction and creatine phosphokinase isoenzyme after treatment.Results The ratio of TIMI blood flow grade 3 in the observation group was significantly higher than that in the control group immediately after treatment(P< 0.05),and the level of creatine phosphokinase isoenzyme in the observation group was significantly lower than that in the control group at 12 h after treatment(P< 0.05),and the left ventricular ejection fraction in the observation group was significantly higher than that in the control group at 1 week after treatment.Follow up showed that the incidence of adverse cardiac events in the observation group was significantly lower than that in the control group within one month(2.27% vs 19.05%,P< 0.05).Conclusion Tirofiban sodium chloride injection can effectively improve the blood flow,increase left ventricular ejection fraction,decrease the level of creatine phosphokinase isoenzyme and reduce the risk of adverse cardiac events.
Objective To analyze the effects of tirofiban hydrochloride sodium chloride injection on left ventricular ejection fraction(LVEF)and creatine phosphokinase isoenzyme(CK)in patients with acute myocardial infarction(AMI).Methods 86 patients with AMI were randomly divided into two groups:the control group(n= 42)received direct interventional therapy,and the observation group(n= 44)were treated with tirofiban first and then interventional therapy.Changes of left ventricular ejection fraction and creatine phosphokinase isoenzyme after treatment.Results The ratio of TIMI blood flow grade 3 in the observation group was significantly higher than that in the control group immediately after treatment(P< 0.05),and the level of creatine phosphokinase isoenzyme in the observation group was significantly lower than that in the control group at 12 h after treatment(P< 0.05),and the left ventricular ejection fraction in the observation group was significantly higher than that in the control group at 1 week after treatment.Follow up showed that the incidence of adverse cardiac events in the observation group was significantly lower than that in the control group within one month(2.27% vs 19.05%,P< 0.05).Conclusion Tirofiban sodium chloride injection can effectively improve the blood flow,increase left ventricular ejection fraction,decrease the level of creatine phosphokinase isoenzyme and reduce the risk of adverse cardiac events.
引文
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[7] 刘艳,王辉.肌钙蛋白I与肌酸激酶同工酶在老年人急性心肌梗死中的应用价值[J].检验医学与临床,2015,25(6):732-733.
[8] 林德兴,王琳,范张欣.急性心肌梗死患者前白蛋白、脑钠肽、心肌肌钙蛋白T、肌酸激酶同工酶与短期预后的关系[J].中国循证心血管医学杂志,2017,15(12):1507-1508.
[9] FU WEN-BO,SF DING,ZN CHEN,et al.Effect of Tirofiban injection from thrombus aspirating catheter in patients with acute myocardial infarction during primary percutaneous coronary intervention with no-reflow[J].Chinese Journal of Interventional Imaging & Therapy,2015,12(2):70-73.
[10] 吴海丽,李贤斌.替罗非班用于急性心肌梗死介入治疗的疗效及安全性分析[J].西南国防医药,2016,26(9):1025-1027.
[2] 江建良,项丽,李晖,等.室壁运动积分与左室射血分数对急性心肌梗死后心力衰竭的预测[J].实用医学杂志,2017,33(1):104-107.
[3] X LIU,P DONG,S XING,et al.Clinical evaluation of thrombus aspiration combined with tirofiban in patients with acute myocardial infarction with elective percutaneous coronary intervention[J].Journal of International Medical Research,2013,41(5):1532-1540.
[4] 杨文青,李丽,蔡春红,等.新生儿高胆红素血症对血清磷酸肌酸激酶同工酶和肌钙蛋白的影响[J].实用医院临床杂志,2016,13(5):50-53.
[5] 陈章强,洪浪,王洪,等.通心络对AMI延迟介入治疗术后血小板活化因子、血管内皮功能、TIMI血流分级的影响[J].中国中西医结合杂志,2016,14(4):415-420.
[6] Y LIU,HL LIU,GY GENG,et al.Effects of Coronary Arterial Injection of Tirofiban on Diabetes Mellitus Complicated with Acute Myocardial Infarction in the Elderly[J].Acta Cardiologica Sinica,2013,29(6):550-556.
[7] 刘艳,王辉.肌钙蛋白I与肌酸激酶同工酶在老年人急性心肌梗死中的应用价值[J].检验医学与临床,2015,25(6):732-733.
[8] 林德兴,王琳,范张欣.急性心肌梗死患者前白蛋白、脑钠肽、心肌肌钙蛋白T、肌酸激酶同工酶与短期预后的关系[J].中国循证心血管医学杂志,2017,15(12):1507-1508.
[9] FU WEN-BO,SF DING,ZN CHEN,et al.Effect of Tirofiban injection from thrombus aspirating catheter in patients with acute myocardial infarction during primary percutaneous coronary intervention with no-reflow[J].Chinese Journal of Interventional Imaging & Therapy,2015,12(2):70-73.
[10] 吴海丽,李贤斌.替罗非班用于急性心肌梗死介入治疗的疗效及安全性分析[J].西南国防医药,2016,26(9):1025-1027.
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