病毒感染在口腔鳞状细胞癌中的病因学作用
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摘要
口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是上皮来源口腔恶性肿瘤中最常见的一种,其病因为遗传、环境、感染等多因素的相互作用。随着烟酒等经典因素的逐年减少,病毒感染在OSCC发生发展中的作用愈发重要。现已确认人类乳头状瘤病毒(human papillomavirus,HPV)是OSCC发生的危险因素之一,另有部分学者认为,EB病毒(Epstein-Barr virus,EBV)、单纯疱疹病毒I型(herpes simplex virus 1,HSV-1)、人类巨细胞病毒(human cytomegalovirus,HCMV)、人类疱疹病毒6型(human herpes virus-6,HHV-6)、丙型肝炎病毒(hepatitis C virus,HCV)等多种病毒也具有口腔致癌能力,但这些观点尚存争议。该文回顾了近些年的相关文献,旨在揭示病毒感染对OSCC的病因学作用,并为未来的研究提供参考思路。
Oral squamous cell carcinoma(OSCC) is one of the most common oral epithelial malignant tumors.Its etiology is commonly concerned as interactions of genes, environment, infection and other multi-factors.Human papillomavirus has been identified as one of the risk factors for the occurrence of OSCC, while some other scholars believe that Epstein-Barr virus, herpes simplex virus type I, human cytomegalovirus,human herpes virus-6,hepatitis C virus and other viruses can also cause oral cancer, but these views are still controversial. This article reviews the literature in recent years to reveal the etiological role of viral infections in OSCC and provide ideas for future research.
Oral squamous cell carcinoma(OSCC) is one of the most common oral epithelial malignant tumors.Its etiology is commonly concerned as interactions of genes, environment, infection and other multi-factors.Human papillomavirus has been identified as one of the risk factors for the occurrence of OSCC, while some other scholars believe that Epstein-Barr virus, herpes simplex virus type I, human cytomegalovirus,human herpes virus-6,hepatitis C virus and other viruses can also cause oral cancer, but these views are still controversial. This article reviews the literature in recent years to reveal the etiological role of viral infections in OSCC and provide ideas for future research.
引文
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[3] Di Pardo BJ,Bronson NW,Diggs BS,et al.The global burden of esophageal cancer:A disability-adjusted life-year approach[J].World J Surg,2016,40(2):395-401.
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[26] Jalouli M,Jalouli J,Hasseus B,et al.Nested PCR for detection of HSV-1 in oral mucosa[J].Med Oral Patol Oral Cir Bucal,2015,20(6):664-669.
[27] Michaelis M,Doerr H,Cinatl J.The story of human cytomegalovirus and cancer:Increasing evidence and open questions[J].Neoplasia,2009,11(1):1-9.
[28] Melnick M,Sedghizadeh PP,Allen CM,et al.Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands:Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship[J].Exp Mol Pathol,2012,92(1):118-125.
[29] Hou W,Shu Q.Primary study on human papillomavirus type 16 and human cytomegalovirus infections in oral squamous cell carcinoma[J].J Compr Stomatol,1996,12(2):70-72.
[30] Delavarian Z,Pakfetrat A,Falaki F,et al.The role of viruses in oral squamous cell carcinoma in young patients in Khorasan(northeast of Iran)[J].J Appl Sci,2010,10(11):981-985.
[31] Saravani S,Kadeh H,Miri-Moghaddam E,et al.Human cytomegalovirus in oral squamous cell carcinoma in southeast of Iran[J].Jundishapur J Microbiol,2015,8(8):1-3.
[32] Yang YY,Koh LW,Tsai JH,et al.Involvement of viral and chemical factors with oral cancer in Taiwan[J].Jpn J Clin Oncol,2004,34(4):176-183.
[33] Pantry S,Medveczky P.Latency,integration,and reactivation of human herpesvirus-6[J].Viruses,2017,9(7):194.
[34] Yadav M,Arivananthan M,Chandrashekran A,et al.Human herpesvirus-6(HHV-6)DNA and virus-encoded antigen in oral lesions[J].J Oral Pathol Med,2010,26(9):393-401.
[35] Liu JL,Xu ZK,Zhao Y,et al.Relationship between human herpesvirus 6 infection and oral squamous cell carcinoma[J].Chin J Vector Biol Control,2003,17(4):334.
[36] Nagao Y,Sata M.High incidence of multiple primary carcinomas in HCV-infected patients with oral squamous cell carcinoma[J].Med Sci Monit,2009,15(9):453-459.
[37] Smh A,Abushouk AI,Attia A,et al.Malignant transformation of oral lichen planus and oral lichenoid lesions:A meta-analysis of 20095 patient data[J].Oral Oncol,2017,68:92-102.
[38] Carrozzo M,Scally K.Oral manifestations of hepatitis C virus infection.[J].Kidney Int,2014,46(24):7534.
[39] Su FH,Chang SN,Chen PC,et al.Positive association between hepatitis C Infection and oral cavity cancer:A nationwide population-based cohort study in Taiwan[J].PLoS One,2012,7(10):e48109.
[2] Woelber L,Breuer J,Meyer T,et al.Oral human papillomavirus in women with high-grade cervical intraepithelial neoplasia[J].J Low Genit Tract Dis,2017,21(3):177.
[3] Di Pardo BJ,Bronson NW,Diggs BS,et al.The global burden of esophageal cancer:A disability-adjusted life-year approach[J].World J Surg,2016,40(2):395-401.
[4] St John MA.Inflammatory mediators drive metastasis and drug resistance in head and neck squamous cell carcinoma[J].Laryngoscope,2015,125(S3):S1-11.
[5] Benson E,Li R,Eisele D,et al.The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas[J].Oral Oncol,2014,50(6):565-574.
[6] Wang F,Zhang H,Xue Y,et al.A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas[J].Cancer Med,2017,6(5):910-917.
[7] Kreimer AR,Clifford GM,Boyle P,et al.Human papillomavirus types in head and neck squamous cell carcinomas worldwide:A systematic review[J].Cancer Epidemiol Biomarkers Prev,2005,14(2):467-475.
[8] Jiang S,Dong Y.Human papillomavirus and oral squamous cell carcinoma:A review of HPV-positive oral squamous cell carcinoma and possible strategies for future[J].Curr Probl Cancer,2017,41(5):323-327.
[9] Anaya-Saavedra G,Ramírez-Amador V,Irigoyen-Camacho ME,et al.High association of human papillomavirus infection with oral cancer:A case-control study[J].Arch Med Res,2008,39(2):189-197.
[10] Kansy K,Thiele O,Freier K.The role of human papillomavirus in oral squamous cell carcinoma:myth and reality[J].Oral Maxillofac Surg,2014,18(2):165-172.
[11] Gupta S,Gupta S.Role of human papillomavirus in oral squamous cell carcinoma and oral potentially malignant disorders:A review of the literature[J].Indian J Dent,2015,6(2):91.
[12] Kikuchi K,Inoue H,Miyazaki Y,et al.Epstein-Barr virus(EBV)-associated epithelial and non-epithelial lesions of the oral cavity[J].Jpn Dent Sci Res,2017,53(3):95-109.
[13] Oonishi A,Kariyama K.EB virus[J].Nihon Rinsho,2015,73(Suppl 9):654.
[14] Kikuchi K,Noguchi Y,de Rivera M W,et al.Detection of Epstein-Barr virus genome and latent infection gene expression in normal epithelia,epithelial dysplasia,and squamous cell carcinoma of the oral cavity[J].Tumour Biol,2015,37(3):3389.
[15] She Y,Nong X,Zhang M,et al.Epstein-Barr virus infection and oral squamous cell carcinoma risk:A meta-analysis[J].PLoS One,2017,12(10):e0186860.
[16] Andrea K,Enik? F,Tamás G,et al.Epstein-Barr virus preva-lence in oral squamous cell cancer and in potentially malignant oral disorders in an eastern Hungarian population[J].Eur J Oral Sci,2009,117(5):536-540.
[17] Jalouli J,Jalouli M,Sapkota D,et al.Human papilloma virus,herpes simplex virus and epstein barr virus in oral squamous cell carcinoma from eight different countries[J].Anticancer Res,2012,32(2):571-580.
[18] Hillbertz N,Hirsch J,Jalouli J,et al.Viral and molecular aspects of oral cancer[J].Anticancer Res,2012,32(10):4201-4212.
[19] Saravani S,Miri-Moghaddam E,Sanadgol N,et al.Human herpesvirus-6 and epstein-barr virus infections at different histopathological grades of oral squamous cell carcinomas[J].IJPM,2014,5(10):1231-1238.
[20] Desai DV,Kulkarni SS.Herpes simplex virus:The interplay between HSV,Host,and HIV-1[J].Viral Immunol,2015,28(10):546-555.
[21] Sand L,Jalouli J.Viruses and oral cancer.Is there a link?[J].Microbes Infect,2014,16(5):371-378.
[22] James S,Kimberlin D.Neonatal herpes simplex virus infection epidemiology and treatment[J].Clin Perinatol,2015,42(1):47.
[23] Everett RD.HSV-1 biology and life cycle[M].Springer:New York,2014:1-17.
[24] Polz-Gruszka D,Stec A,Dworzanski J,et al.EBV,HSV,CMV and HPV in laryngeal and oropharyngeal carcinoma in polish patients[J].Anticancer Res,2015,35(3):1657-1661.
[25] Mokhtari M,Beiraghdar M.Evaluation of the prevalence of herpes simplex-1 infection in oral squamous cell carcinoma specimens in Alzahra and Kashani Hospitals with polymerase chain reaction method in 2012-2013[J].Adv biomed Res,2015,4(1):173.
[26] Jalouli M,Jalouli J,Hasseus B,et al.Nested PCR for detection of HSV-1 in oral mucosa[J].Med Oral Patol Oral Cir Bucal,2015,20(6):664-669.
[27] Michaelis M,Doerr H,Cinatl J.The story of human cytomegalovirus and cancer:Increasing evidence and open questions[J].Neoplasia,2009,11(1):1-9.
[28] Melnick M,Sedghizadeh PP,Allen CM,et al.Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands:Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship[J].Exp Mol Pathol,2012,92(1):118-125.
[29] Hou W,Shu Q.Primary study on human papillomavirus type 16 and human cytomegalovirus infections in oral squamous cell carcinoma[J].J Compr Stomatol,1996,12(2):70-72.
[30] Delavarian Z,Pakfetrat A,Falaki F,et al.The role of viruses in oral squamous cell carcinoma in young patients in Khorasan(northeast of Iran)[J].J Appl Sci,2010,10(11):981-985.
[31] Saravani S,Kadeh H,Miri-Moghaddam E,et al.Human cytomegalovirus in oral squamous cell carcinoma in southeast of Iran[J].Jundishapur J Microbiol,2015,8(8):1-3.
[32] Yang YY,Koh LW,Tsai JH,et al.Involvement of viral and chemical factors with oral cancer in Taiwan[J].Jpn J Clin Oncol,2004,34(4):176-183.
[33] Pantry S,Medveczky P.Latency,integration,and reactivation of human herpesvirus-6[J].Viruses,2017,9(7):194.
[34] Yadav M,Arivananthan M,Chandrashekran A,et al.Human herpesvirus-6(HHV-6)DNA and virus-encoded antigen in oral lesions[J].J Oral Pathol Med,2010,26(9):393-401.
[35] Liu JL,Xu ZK,Zhao Y,et al.Relationship between human herpesvirus 6 infection and oral squamous cell carcinoma[J].Chin J Vector Biol Control,2003,17(4):334.
[36] Nagao Y,Sata M.High incidence of multiple primary carcinomas in HCV-infected patients with oral squamous cell carcinoma[J].Med Sci Monit,2009,15(9):453-459.
[37] Smh A,Abushouk AI,Attia A,et al.Malignant transformation of oral lichen planus and oral lichenoid lesions:A meta-analysis of 20095 patient data[J].Oral Oncol,2017,68:92-102.
[38] Carrozzo M,Scally K.Oral manifestations of hepatitis C virus infection.[J].Kidney Int,2014,46(24):7534.
[39] Su FH,Chang SN,Chen PC,et al.Positive association between hepatitis C Infection and oral cavity cancer:A nationwide population-based cohort study in Taiwan[J].PLoS One,2012,7(10):e48109.