基于Caco-2细胞模型研究青黛配方分散片吸收机制

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英文篇名：Study on the absorption mechanism of Qingdai formula dispersible tablets based on Caco-2 cell 作者：闵志强 ; 蒋淼 ; 石娅萍 英文作者：MIN Zhi-qiang;JANG Miao;SHI Ya-ping;Chengdu University of Traditional Chinese Medicine; 关键词：青黛 ; 固体分散 ; Caco-2细胞模型 ; 吸收机制 英文关键词：Qingdai;;solid dispersion;;Caco-2 cell model;;absorption mechanism 中文刊名：LCZY 英文刊名：Pharmacy and Clinics of Chinese Materia Medica 机构：成都中医药大学药学院; 出版日期：2017-05-25 出版单位：中药与临床 年：2017 期：v.8;No.43 基金：四川省教育厅资助科研项目 利用固体分散技术提高青黛饮片药效及吸收机制研究编号14ZB0098 语种：中文; 页：LCZY201703012 页数：3 CN：03 ISSN：51-1723/R 分类号：46-48

摘要

目的:探讨青黛跨膜吸收转运机制。方法:采用Caco-2细胞模型,进行双向转运实验,说明药物转运方式,并比较两种青黛区别,最后考察不同浓度的P-gp、MRP和CYP3A4抑制剂维拉帕米、丙磺舒和酮康唑对青黛分散片与原剂型有效成分的转运量的影响。结果:固体分散技术可以促进青黛有效成分的跨膜转运,该转运为被动转运过程,转运吸收不受P-gp、MRP和CYP3A4影响。结论:固体分散技术可通过青黛溶解度促进其有效成分的吸收。
        Objective: To explore the absorption mechanism of Qingdai. Method: Two-way transport experiments were conducted using Caco-2 cell model to explore drug transport way, and compare the difference between two kinds of Qingdai. Then, the influence of different concentrations of P-gp, MRP and CYP3A4 inhibitor verapamil, probenecid and ketoconazole on the transport of effective components of Qingdai dispersion tablets and the original formulation were investigated. Result: Solid dispersion technology can promote the transmembrane transport of effective components of Qingdai. The transport was passive transport which was not affected by P-gp, MRP and CYP3A4. Conclusion: Solid dispersion technology can promote the absorption of active ingredients of Qingdaiby increasing the solubility.

引文

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