胃舒方挥发油包合工艺及无机陶瓷膜对其口服液精制效果研究

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英文篇名：Optimization of Inclusion Process of Volatile Oil in Weisu Recipe and Study on the Effect of Inorganic Ceramic Membrane on Its Oral Liquid 作者：宫凯敏 ; 王银洁 ; 李文静 ; 刘军 英文作者：GONG Kaimin;WANG Yinjie;LI Wenjing;LIU Jun;Traditional Chinese Medicine Hospital of Yinchuan; 关键词：胃舒口服液 ; 挥发油 ; 包合工艺 ; 无机陶瓷膜 ; 精制 英文关键词：Weisu Oral Liquid;;essential oil;;inclusion process;;inorganic ceramic membrane;;refine 中文刊名：XNXY 英文刊名：Journal of Ningxia Medical University 机构：银川市中医医院; 出版日期：2019-01-30 出版单位：宁夏医科大学学报 年：2019 期：v.41;No.244 基金：宁夏自然科学基金(NZ14245) 语种：中文; 页：XNXY201901008 页数：4 CN：01 ISSN：64-1064/R 分类号：39-41+49

摘要

目的优化胃舒口服液中挥发油的包合工艺,考察用无机陶瓷膜精制胃舒口服液的可行性,探讨提高胃舒口服液药效技术。方法通过正交实验设计,以挥发油包合率为评价指标,筛选最佳挥发油包合工艺;以黄芩苷转移率为评价指标,考查不同孔径膜及不同操作参数对有效成分含量的影响。结果优选最佳包合工艺为研磨时间40min,温度35℃,挥发油∶β-CD=1∶15,β-CD∶纯化水=1∶3。使用孔径为800nm的无机陶瓷膜可获得较好的分离效果,最佳的操作条件包括压差0.2MPa,过膜温度40℃,生药浓度为0.05g·mL-1。结论确定的挥发油包合工艺包合率高,采用800nm的无机陶瓷膜对胃舒口服液进行过滤,在适当的操作条件下可取的较好的精制效果。
        Objective To optimize β-cyclodextrin inclusion process for volatile from Weisu Oral Liquid,and investigate the optimum membrane pore size and the best operating conditions of Weisu Oral Liquid by inorganic ceramic membrane,and explore the technology of improving the pharmacodynamics of Weishu Oral Liquid. Methods By designing the orthogonal experiments,the inclusion ratio of volatile oil was selected as the evaluation index. The best volatile oil inclusion process was screened. The baicalin transfer rate was used as an evaluation index to examine the effect of different pore size membranes and different operation parameters on the content of effective components. Results The optimum conditions for inclusion process were as follow:Grinding time was 40 min,the temperature was 35℃,the ratio of volatile oil to β-CD was 1∶15,the rates ofβ-cyclodextrin to the volume of water was 1∶3,Inorganic ceramic membrane(800 nm)showed better separation efficiency.The optimum operation pressure was 0.2 MPa,the temperature for filtration membrane was 40℃ and concentration was 0.05 g·m L~(-1).Conclusion The inclusion rate of volatile oil is high. The 800 nm inorganic ceramic membrane is used to filter Weishu Oral Liquid,and the better refining effect can be obtained under appropriate operating conditions.

引文

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