GM-CSF对兔血液动力性脑缺血后颅内侧支动脉生成的影响

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英文篇名：Effect of GM-CSF on collateral arteriogenesis of posterior cerebral circulation in rabbits with hemodynamic ischemia 作者：张桂运 ; 陈左权 ; 凌锋 英文作者：ZHANG Gui-yun;CHEN Zuo-quan;LING Feng;Dept. of Neurosurgery,Tongji Hospital,Tongji University;Dept. of Neurosurgery,Tenth People's Hospital,Tongji University;Dept. of Neurosurgery,Xuanwu Hospital,Capital Medical University; 关键词：粒-巨噬细胞集落刺激因子 ; 侧支动脉 ; 动脉生成 ; 脑缺血 英文关键词：granulocyte-macrophage colony-stimulating factor;;collaterals;;arteriogenesis;;ischemia 中文刊名：TJIY 英文刊名：Journal of Tongji University(Medical Science) 机构：同济大学附属同济医院神经外科;同济大学附属第十人民医院神经外科;首都医科大学附属宣武医院神经外科; 出版日期：2015-02-15 出版单位：同济大学学报(医学版) 年：2015 期：v.36 基金：国家自然科学基金(30872678) 语种：中文; 页：TJIY201501003 页数：4 CN：01 ISSN：31-1901/R 分类号：11-14

摘要

目的研究粒-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)对兔后循环血液动力性脑缺血后侧支循环生成的影响。方法 40只新西兰大白兔随机分为对照组、假手术组、非治疗模型组、GM-CSF治疗模型组、生理盐水治疗模型组,每组8只。模型组均采用手术结扎右侧锁骨下动脉椎动脉开口近端。采用超选择脑血管造影及染色乳胶灌注法检测盗血及血管管径、血管密度及后分水岭区面积。结果GM-CSF治疗模型组颅内前循环动脉管径较非治疗模型组明显增粗(P<0.01),侧支血管密度明显增加。非治疗模型组颅内前循环动脉管径及侧支血管密度较对照组有所增加,但差异无统计学意义(P>0.01)。结论 GMCSF对兔后循环血液动力性脑缺血后侧支动脉的生成具有重要作用。
        Objective To investigate the effect of GM-CSF on collateral arteriogenesis of posterior cerebral circulation in rabbits with hemodynamic ischemia. Methods Forty NewZealand rabbits were randomly divided into five groups( control group,sham operation group,model group,GM-CSF group and saline control group). In all the groups except the control one,the right subclavian artery proximal to the orifice of vertebral artery was ligated. Results Compared to the control group,the diameters of resistant arteries in posterior watershed,posterior communicating arteries and posterior cerebral arteries were enlarged significantly as well as the vascular density in GM-CSF group; and partial resistant arteries in posterior watershed were transformed into conductive arteries. The similar results were seen in the model group,but there was no statistical significance compared to the control group. Conclusion GM-CSF exerts a positive effect on collateral arteriogenesis of posterior cerebral circulation in rabbits with hemodynamic ischemia.

引文

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