物质成瘾与昼夜节律相互关系的研究进展
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摘要
药物成瘾是一个突出的社会问题,给家庭和社会带来了巨大损失。然而其发生机制尚不完全清楚,近年来,在众多机制假说中生物节律机制的研究越来越受到关注。本文将以可卡因为例,从其体内代谢过程、对人体危害、作用机制,到昼夜节律系统、以及物质成瘾和昼夜节律两者相互关系的研究进展,做一详细综述。
Drug addiction is a prominent social problem,which has brought great losses to families and society. However,the mechanism is not completely clear. In recent years,the research on the biological rhythm mechanism of drug addiction has attracted more and more attention among many mechanism hypotheses. This paper will take cocaine as an example to make a detailed review from its physiological effects,internal metabolic processes,harm to human body and mechanism of action,to the circadian rhythm system,as well as the research progress of the relationship between substance addiction and circadian rhythm.
Drug addiction is a prominent social problem,which has brought great losses to families and society. However,the mechanism is not completely clear. In recent years,the research on the biological rhythm mechanism of drug addiction has attracted more and more attention among many mechanism hypotheses. This paper will take cocaine as an example to make a detailed review from its physiological effects,internal metabolic processes,harm to human body and mechanism of action,to the circadian rhythm system,as well as the research progress of the relationship between substance addiction and circadian rhythm.
引文
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[13]Weiss RD,Gawin FH. Protracted elimination of cocaine metabolites in long-term high-dose cocaine abusers[J]. Am J Med,1988,85:879-880.
[14]Kim ST,Park T. Acute and Chronic Effects of Cocaine on Cardiovascular Health[J]. Int J Mol Sci,2019,20:584.
[15]Leece P,Rajaram N,Woolhouse S,et al. Acute and chronic respiratory symptoms among primary care patients who smoke crack cocaine[J]. J Urban Health,2013,90:542-551.
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[24]Sharma HS,Muresanu D,Sharma A,et al. Cocaine-induced breakdown of the blood-brain barrier and neurotoxicity[J]. Int Rev Neurobiol,2009,88:297-334.
[25]Lason W. Neurochemical and pharmacological aspects of cocaine-induced seizures[J]. Pol J Pharmacol,2001,53:57-60.
[26]Prakash A,Das G. Cocaine and the nervous system[J]. Int J Clin Pharmacol Ther Toxicol,1993,31:575-581.
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[28]Caligiore D,Pezzulo G,Baldassarre G,et al. Consensus Paper:Towards a Systems-Level View of Cerebellar Function:the Interplay Between Cerebellum,Basal Ganglia,and Cortex[J]. Cerebellum,2017,16:203-229.
[29]Salamone JD,Correa M. The mysterious motivational functions of mesolimbic dopamine[J]. Neuron,2012,76:470-485.
[30]Yager LM,Garcia AF,Wunsch AM et al. The ins and outs of the striatum:role in drug addiction[J]. Neuroscience 2015,301:529-541
[31]Taylor SB,Lewis CR,Olive MF. The neurocircuitry of illicit psychostimulant addiction:acute and chronic effects in humans[J]. Subst Abuse Rehabil,2013,4:29-43.
[32]Baimel C,Bartlett SE,Chiou LC,et al. Orexin/hypocretin role in reward:implications for opioid and other addictions[J]. Br J Pharmacol,2015,172:334-348.
[33]Berridge KC,Kringelbach ML. Pleasure systems in the brain[J]. Neuron,2015,86:646-664.
[34]Grall-Bronnec M,Sauvaget A. The use of repetitive transcranial magnetic stimulation for modulating craving and addictive behaviours:a critical literature review of efficacy,technical and methodological considerations[J]. Neurosci Biobehav Rev,2014,47:592-613.
[35]Olsen CM. Natural rewards,neuroplasticity,and non-drug addictions[J]. Neuropharmacology,2011,61:1109-1122.
[36]Ikemoto S. Brain reward circuitry beyond the mesolimbic dopamine system:a neurobiological theory[J]. Neurosci Biobehav Rev,2010,35:129-150.
[37]Carr DB,Sesack SR. Projections from the rat prefrontal cortex to the ventral tegmental area_target specificity in the syn-aptic associations with mesoaccumbens and mesocortical neurons[J]. J Neurosci,2000,20:3864-3873.
[38]Russo SJ,Nestler EJ. The brain reward circuitry in mood disorders[J]. Nat Rev Neurosci,2013,14:609-625.
[39] Pomara C,Cassano T,D’Errico S,et al. Data available on the extent of cocaine use and dependence_biochemistry,pharmacologic effects and global burden of disease of cocaine abusers[J]. Curr Med Chem,2012,19(33),5647–5657.
[40] Cadet JL,Brannock C,Jayanthi S,et al. Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal:evidence from a long-access self-administration model in the rat[J]. Mol Neurobiol,2015,51:696-717.
[41]Renthal W,Nestler EJ. Chromatin regulation in drug addiction and depression[J]. Dialogues Clin Neurosci,2009,11:257-268.
[42]Nestler EJ. Review. Transcriptional mechanisms of addiction:role of Delta Fos B[J]. Philos Trans R Soc Lond B Biol Sci,2008,363:3245-3255.
[43]Robison AJ,Nestler EJ. Transcriptional and epigenetic mechanisms of addiction[J]. Nat Rev Neurosci,2011,12:623-637.
[44]Nestler EJ. Transcriptional mechanisms of drug addiction[J]. Clin Psychopharmacol Neurosci,2012,10:136-143.
[45]Ruffle JK. Molecular neurobiology of addiction:what's all the(Delta)Fos B about?[J]. Am J Drug Alcohol Abuse,2014,40:428-437.
[46]Nestler EJ. Cellular basis of memory for addiction[J]. Dialogues Clin Neurosci,2013,15:431-443.
[47]Hastings MH,Reddy AB,Maywood ES. A clockwork web:circadian timing in brain and periphery,in health and disease[J].Nat Rev Neurosci,2003,4:649-661.
[48]Edgar RS,Green EW,Zhao Y,et al. Peroxiredoxins are conserved markers of circadian rhythms[J]. Nature,2012,485:459-464.
[49]Lowrey PL,Takahashi JS. Mammalian circadian biology:elucidating genome-wide levels of temporal organization[J]. Annu Rev Genomics Hum Genet,2004,5:407-441.
[50]Panda S,Hogenesch JB,Kay SA. Circadian rhythms from flies to human[J]. Nature,2002,417:329-335.
[51]Weger M,Diotel N,Dorsemans AC,et al. Stem cells and the circadian clock[J]. Dev Biol,2017,431:111-123.
[52]Andreani TS,Itoh TQ,Yildirim E,et al. Genetics of Circadian Rhythms[J]. Sleep Med Clin,2015,10:413-421.
[53]Bae K,Jin X,Maywood ES,et al. Differential functions of m Per1,m Per2,and m Per3 in the SCN circadian clock[J]. Neuron,2001,30:525-536.
[54]Pendergast JS,Oda GA,Niswender KD,et al. Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s)[J]. Proc Natl Acad Sci U S A,2012,109:14218-14223.
[55]Sujino M,Masumoto KH,Yamaguchi S,et al. Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrhythmic mice[J]. Curr Biol,2003,13:664-668.
[56]Ralph MR,Foster RG,Davis FC,et al. Transplanted suprachiasmatic nucleus determines circadian period[J]. Science,1990,247:975-978.
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