抗菌肽研究进展及应用
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摘要
抗菌肽因其具有广谱高效抗菌特性,且不易引起耐药性,成为最有潜力的肽类抗生素,被广泛应用于医药和饲料添加剂等领域。文章综合近年来抗菌肽的研究,概述了抗菌肽的理化特性、作用机制及应用。
Antibacterial peptides have been widely used in the fields of medicine and feed additives because of their broad-spectrum and efficient antibacterial properties, and not easy to cause resistance, and become the most potential peptide antibiotics. Based on the studies of antimicrobial peptides in recent years, this paper summarized the physicochemical properties, mechanism and application of antimicrobial peptides.
Antibacterial peptides have been widely used in the fields of medicine and feed additives because of their broad-spectrum and efficient antibacterial properties, and not easy to cause resistance, and become the most potential peptide antibiotics. Based on the studies of antimicrobial peptides in recent years, this paper summarized the physicochemical properties, mechanism and application of antimicrobial peptides.
引文
[1]王俊杰,赵燕,涂勇刚,等.蛋源性抗菌肽的研究进展[J].食品科学,2013,34(9):399-403.
[2]华绍烽,周凯华.天然抗菌剂──抗菌肽的研究进展[J].中兽医医药杂志,1998(5):15-16.
[3]胡云龙,赵学忠.抗菌肽的分子生物学研究进展[J].中国生物工程杂志,1997,17(3):13-17.
[4]王芳,张双全.抗菌肽抗癌作用机理的研究进展[J].自然科学进展:国家重点实验室通讯,1999(2):97-102.
[5]郭玉梅.某些抗菌肽的研究进展[J].生命科学,1997(1):29-30.
[6]尚田田,徐彦召,杭柏林,等.抗菌肽的抗菌机理及构效关系研究进展[J].黑龙江畜牧兽医,2013(9):26-28.
[7]苏庆红,许晓群,王郡甫.抗菌肽的分子设计研究进展[J].化学与生物工程,2012,29(11):1-4.
[8]刘耀,夏培元,任建东.抗菌肽的免疫调节及其在脓毒症中的作用[J].免疫学杂志,2013(7):632-636.
[9]宋士刚,杨在宾,杨维仁,等.添加不同水平抗菌肽对肉鸡生产性能、屠宰性能及盲肠菌群影响的研究[J].饲料工业,2012,33(23):16-19.
[10]周继章.抗菌肽抗病的研究进展[J].中国畜牧兽医,2012,39(7):204-208.
[11]何英翠,刘虹霞,张国刚.天然抗生素—抗菌肽[J].沈阳药科大学学报,2012(8):656-660.
[12]崔敬爱,宋玉涛,詹冬玲,等.Spinigerinα抗菌肽的理化特性研究[J].食品与发酵科技,2013(1):55-57.
[13]岳阳,崔敬爱,陈晓平.蚕蛹抗菌肽的分离纯化及其理化性质的研究[J].食品与发酵科技,2013(2):63-67.
[14]Chan D I,Prenner E J,Vogel H J.Tryptophan-and arginine-rich antimicrobial peptides:structures and mechanisms of action[J].Biochimica et Biophysica Acta(BBA)-Biomembranes,2006,1758(9):1 184-1 202.
[15]黎观红,洪智敏,贾永杰,等.抗菌肽的抗菌作用及其机制[J].动物营养学报,2011,23(4):546-555.
[16]汪吴晶,高金燕,佟平,等.抗菌肽的作用机制、应用及改良策略[J].动物营养学报,2017,29(11):3 885-3 892.
[17]Hodges R S,Jiang Z.Antimicrobial peptides:WO,US 20110028386 A1[P].2011,199(2):199-204.
[18]Subbalakshmi C,Sitaram N.Mechanism of antimicrobial action of indolicidin.[J].Fems Microbiology Letters,1998,160(1):91-96.
[19]Yan J,Wang K,Dang W,et al.Two hits are better than one:membrane-active and DNA binding-related double-action mechanism of NK-18,a novel antimicrobial peptide derived from mammalian NK-lysin[J].Antimicrobial Agents&Chemotherapy,2013,57(1):220-228.
[20]Andreu D,Rivas L.Animal antimicrobial peptides:an overview[J].Biopolymers,2015,47(6):415-433.
[21]张东东,尚德静.抗菌肽作为新型抗感染药物的潜力及应用前景[J].中国生化药物杂志,2016(1):178-182.
[22]Song D,Zong X,Zhang H,et al.Antimicrobial peptide Cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia[J].International Immunopharmacology,2015,25(1):141-147.
[23]Narayana J L,Huang H N,Wu C J,et al.Epinecidin-1 antimicrobial activity:invitro,membrane lysis and in vivo,efficacy against Helicobacter pylori,infection in a mouse model[J].Biomaterials,2015,61:41-51.
[24]Findlay B,Zhanel G G,Schweizer F.Cationic amphiphiles,a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold[J].Antimicrob Agents Chemother,2010,54(10):4 049-4 058.
[25]王宏.小菜蛾抗菌肽px CECA1抗细菌和抗流感病毒活性研究[D].武汉:武汉大学,2012.
[26]黄海凤,缑三虎,马银云,等.抗菌肽在细菌感染动物模型中的抗菌活性和毒性评价方法研究进展[J].动物医学进展,2016,37(3):103-108.
[27]刘莉如,滑静,王晓霞,等.抗菌肽对蛋用仔公鸡血液免疫指标和肠道菌群的影响[J].动物营养学报,2012,24(9):1 812-1 818.
[28]白建,杜京旗,郝旺林.海藻粉和抗菌肽对肉鸡生长性能、免疫器官指数和肠道菌群的影响[J].激光生物学报,2016,25(2):170-177.
[29]陈芸,刘旗,邓俊良,等.复合抗菌肽对山羊瘤胃菌群结构的影响[J].浙江农业学报,2017,29(11):1 800-1 808.
[30]姜文,赵鑫,宋凯,等.抗菌肽与植物精油对断奶仔猪生长性能的影响[J].黑龙江畜牧兽医,2016(4):74-76.
[31]De l F C,Silva O N,Lu T K,et al.Antimicrobial Peptides:role in human disease and potential as immunotherapies[J].Pharmacology&Therapeutics,2017,178:132-140.
[32]Shabir U,Ali S,Magray A R,et al.Fish antimicrobial peptides(AMP's)as essential and promising molecular therapeutic agents:a review[J].Microbial Pathogenesis,2018,114:50-56.
[33]杨颜铱,邓俊良,陈芸,等.精料水平和复合抗菌肽对川中黑山羊生长性能及血清中免疫球蛋白、补体、细胞因子和激素水平的影响[J].浙江农业学报,2017,29(8):1 243-1 252.
[34]Casta?eda-Delgado JE,Frausto-Lujan I,González-Curiel I,et al.Differences in cytokine production during aging and its relationship with antimicrobial peptides production[J].Immunological Investigations,2017,46(1):48-58.
[2]华绍烽,周凯华.天然抗菌剂──抗菌肽的研究进展[J].中兽医医药杂志,1998(5):15-16.
[3]胡云龙,赵学忠.抗菌肽的分子生物学研究进展[J].中国生物工程杂志,1997,17(3):13-17.
[4]王芳,张双全.抗菌肽抗癌作用机理的研究进展[J].自然科学进展:国家重点实验室通讯,1999(2):97-102.
[5]郭玉梅.某些抗菌肽的研究进展[J].生命科学,1997(1):29-30.
[6]尚田田,徐彦召,杭柏林,等.抗菌肽的抗菌机理及构效关系研究进展[J].黑龙江畜牧兽医,2013(9):26-28.
[7]苏庆红,许晓群,王郡甫.抗菌肽的分子设计研究进展[J].化学与生物工程,2012,29(11):1-4.
[8]刘耀,夏培元,任建东.抗菌肽的免疫调节及其在脓毒症中的作用[J].免疫学杂志,2013(7):632-636.
[9]宋士刚,杨在宾,杨维仁,等.添加不同水平抗菌肽对肉鸡生产性能、屠宰性能及盲肠菌群影响的研究[J].饲料工业,2012,33(23):16-19.
[10]周继章.抗菌肽抗病的研究进展[J].中国畜牧兽医,2012,39(7):204-208.
[11]何英翠,刘虹霞,张国刚.天然抗生素—抗菌肽[J].沈阳药科大学学报,2012(8):656-660.
[12]崔敬爱,宋玉涛,詹冬玲,等.Spinigerinα抗菌肽的理化特性研究[J].食品与发酵科技,2013(1):55-57.
[13]岳阳,崔敬爱,陈晓平.蚕蛹抗菌肽的分离纯化及其理化性质的研究[J].食品与发酵科技,2013(2):63-67.
[14]Chan D I,Prenner E J,Vogel H J.Tryptophan-and arginine-rich antimicrobial peptides:structures and mechanisms of action[J].Biochimica et Biophysica Acta(BBA)-Biomembranes,2006,1758(9):1 184-1 202.
[15]黎观红,洪智敏,贾永杰,等.抗菌肽的抗菌作用及其机制[J].动物营养学报,2011,23(4):546-555.
[16]汪吴晶,高金燕,佟平,等.抗菌肽的作用机制、应用及改良策略[J].动物营养学报,2017,29(11):3 885-3 892.
[17]Hodges R S,Jiang Z.Antimicrobial peptides:WO,US 20110028386 A1[P].2011,199(2):199-204.
[18]Subbalakshmi C,Sitaram N.Mechanism of antimicrobial action of indolicidin.[J].Fems Microbiology Letters,1998,160(1):91-96.
[19]Yan J,Wang K,Dang W,et al.Two hits are better than one:membrane-active and DNA binding-related double-action mechanism of NK-18,a novel antimicrobial peptide derived from mammalian NK-lysin[J].Antimicrobial Agents&Chemotherapy,2013,57(1):220-228.
[20]Andreu D,Rivas L.Animal antimicrobial peptides:an overview[J].Biopolymers,2015,47(6):415-433.
[21]张东东,尚德静.抗菌肽作为新型抗感染药物的潜力及应用前景[J].中国生化药物杂志,2016(1):178-182.
[22]Song D,Zong X,Zhang H,et al.Antimicrobial peptide Cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia[J].International Immunopharmacology,2015,25(1):141-147.
[23]Narayana J L,Huang H N,Wu C J,et al.Epinecidin-1 antimicrobial activity:invitro,membrane lysis and in vivo,efficacy against Helicobacter pylori,infection in a mouse model[J].Biomaterials,2015,61:41-51.
[24]Findlay B,Zhanel G G,Schweizer F.Cationic amphiphiles,a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold[J].Antimicrob Agents Chemother,2010,54(10):4 049-4 058.
[25]王宏.小菜蛾抗菌肽px CECA1抗细菌和抗流感病毒活性研究[D].武汉:武汉大学,2012.
[26]黄海凤,缑三虎,马银云,等.抗菌肽在细菌感染动物模型中的抗菌活性和毒性评价方法研究进展[J].动物医学进展,2016,37(3):103-108.
[27]刘莉如,滑静,王晓霞,等.抗菌肽对蛋用仔公鸡血液免疫指标和肠道菌群的影响[J].动物营养学报,2012,24(9):1 812-1 818.
[28]白建,杜京旗,郝旺林.海藻粉和抗菌肽对肉鸡生长性能、免疫器官指数和肠道菌群的影响[J].激光生物学报,2016,25(2):170-177.
[29]陈芸,刘旗,邓俊良,等.复合抗菌肽对山羊瘤胃菌群结构的影响[J].浙江农业学报,2017,29(11):1 800-1 808.
[30]姜文,赵鑫,宋凯,等.抗菌肽与植物精油对断奶仔猪生长性能的影响[J].黑龙江畜牧兽医,2016(4):74-76.
[31]De l F C,Silva O N,Lu T K,et al.Antimicrobial Peptides:role in human disease and potential as immunotherapies[J].Pharmacology&Therapeutics,2017,178:132-140.
[32]Shabir U,Ali S,Magray A R,et al.Fish antimicrobial peptides(AMP's)as essential and promising molecular therapeutic agents:a review[J].Microbial Pathogenesis,2018,114:50-56.
[33]杨颜铱,邓俊良,陈芸,等.精料水平和复合抗菌肽对川中黑山羊生长性能及血清中免疫球蛋白、补体、细胞因子和激素水平的影响[J].浙江农业学报,2017,29(8):1 243-1 252.
[34]Casta?eda-Delgado JE,Frausto-Lujan I,González-Curiel I,et al.Differences in cytokine production during aging and its relationship with antimicrobial peptides production[J].Immunological Investigations,2017,46(1):48-58.