中药谱效关系的研究进展
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摘要
中药谱效关系是在中医理论指导下,将中药指纹图谱和药效学通过化学计量学模型进行关联,建立以化学分析与生物活性评价相结合的综合评价体系,有助于揭示中药药效的物质基础,成为中药有效成分预测和质量评价的方法之一。通过查阅国内外相关文献,按照抗菌、抗病毒、抗肿瘤、抗炎、镇痛、祛痰、降尿酸、抗氧化、保肝、抗肝纤维化、抗骨质疏松、抗糖尿病、调节免疫等药效作用,对中药谱效关系研究成果进行分析和总结,建议开发指纹图谱化合物数据库,并实现化合物的自动匹配。
Spectrum-effect relationship of traditional Chinese medicine(TCM)is based on the guidance of traditional Chinese medicine theory. The results of fingerprints and pharmacodynamics of TCM which are corelated by chemometrics model, to establish a comprehensive evaluation system for revealing the material basis of the pharmacodynamics of TCM. Spectrum-effect relationship has been one of the approaches for predicting the active ingredients and quality control in natural products. The study on spectrum-effect relationship of natural products is classified and summarized through literature review from the aspects of anti-microbial,antiviral,antitumor,antiinflammatory, analgesic, expectorant, anti-trioxypurine, antioxidative, anti-hepatic fibrosis, anti-osteoporosis,antidiabetic effects,and liver protection,immunological regulation,and so on,which could offer the proposals and prospects for future research.
Spectrum-effect relationship of traditional Chinese medicine(TCM)is based on the guidance of traditional Chinese medicine theory. The results of fingerprints and pharmacodynamics of TCM which are corelated by chemometrics model, to establish a comprehensive evaluation system for revealing the material basis of the pharmacodynamics of TCM. Spectrum-effect relationship has been one of the approaches for predicting the active ingredients and quality control in natural products. The study on spectrum-effect relationship of natural products is classified and summarized through literature review from the aspects of anti-microbial,antiviral,antitumor,antiinflammatory, analgesic, expectorant, anti-trioxypurine, antioxidative, anti-hepatic fibrosis, anti-osteoporosis,antidiabetic effects,and liver protection,immunological regulation,and so on,which could offer the proposals and prospects for future research.
引文
[1]LI W,SUN X,LIU B,et al.Screening and identification of hepatotoxic component in Evodia rutaecarpa based on spectrum-effect relationship and UPLC-Q-TOFMS[J].Biomed Chromatogr,2016,30(12):1975-1983.
[2]SHENG Z C,LIN Z J,XIAO M L,et al.The spectrum-effect relationship-a rational approach to screening effective compounds,reflecting the internal quality of Chinese herbal medicine[J].Chin JNat Med,2016,14(3):177-184.
[3]吕邵娃,杨阳,赵爽,等.线叶菊抗耐药性细菌感染有效部位的抗菌活性谱效关系[J].中国实验方剂学杂志,2017,23(24):84-89.
[4]LIAO S G,ZHANG L J,SUN F,et al.Identification and characterisation of phenolics in Polygonum capitatum by ultra highperformance liquid chromatography with photodiode array detection and tandem mass spectrometry[J].Phytochem Anal,2013,24(6):556-568.
[5]SHI Z L,LIU Z J,LIU C S,et al.Spectrum-effect relationships between chemical fingerprints and antibacterial effects of Lonicerae japonicae flos and Lonicerae flos base on UPLC and microcalorimetry[J].Front Pharmacol,2016,7:12.
[6]闫峻,刘舒,李伯平,等.基于复方板蓝根颗粒APCI-MS指纹图谱及化学成分的LC-APCI-MSn研究[J].质谱学报,2017,38(3):320-327.
[7]SUN Y,XUE J,LI B,et al.Simultaneous quantification of triterpenoid saponins in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study after oral total saponin of Aralia elata leaves[J].J Sep Sci,2016,39(22):4360-4368.
[8]WANG G,YAO S,CHENG L,et al.Antioxidant and anticancer effection of the volatile oil from various habitats of Selaginella doederleinii Hieron[J].Technol Health Care,2015,23(suppl 1):s21.
[9]樊佳新,包永睿,孟宪生,等.基于微流控芯片技术的荆芥不同药用部位抗肺肿瘤药效关系研究[J].中国中药杂志,2017,42(9):1717-1721.
[10]WANG Y,LI Y,ZHANG Y,et al.Multi-dimensional spectrumeffect relationship of the impact of Chinese herbal formula Lichong Shengsui Yin on ovarian cancer[J].Molecules,2017,22(6):979.
[11]WANG Y L,HU G,ZHANG Q,et al.Screening and characterizing tyrosinase inhibitors from Salvia miltiorrhiza and Carthamus tinctorius by spectrum-effect relationship analysis and molecular docking[J].J Anal Methods Chem,2018,2018:2141389.DOI:10.1155/2018/2141389.
[12]卿勇军,刘文,杜平,等.基于灰色关联度分析戊己丸对胃蛋白酶抑制作用的谱效关系[J].中草药,2017,48(16):3390-3395.
[13]LYU S,DONG S,XU D,et al.Spectrum-effect relationships between fingerprints of Caulophyllum robustum Maxim and inhabited pro-inflammation cytokine effects[J].Molecules,2017,22(11):1826.
[14]WANG C W,FANG X H.Protective effect of rhamnopyranosyl vanilloyl isolated from Scrophularia ningpoensis Hemsl(Scrophulariaceae)root against acute liver injury in mice[J].Trop J Pharm Res,2016,15(7):1499-1505.
[15]ZHANG Q,LEI H M,WANG P L,et al.Bioactive components from Qingwen Baidu Decoction against LPS-induced acute lung injury in rats[J].Molecules,2017,22(5):692.
[16]LEE S E,LIM C,KIM H,et al.A study of the anti-inflammatory effects of the ethyl acetate fraction of the methanol extract of Forsythiae fructus[J].Afr J Tradit Complem,2016,13(5):102-113.
[17]毛艳,贺金华,蔡晓翠,等.维药神香草提取物体外抗炎作用的谱效关系研究[J].中国药房,2017,28(10):1364-1367.
[18]JIANG Y B,ZHONG M,HU M X,et al.Spectrum-effect relationships between high performance iquid chromatography fingerprint and analgesic property of Anisodus tanguticus(Maxim)Pascher(Solanaceae)roots[J].Trop J Pharm Res,2017,16(2):379-386.
[19]王勤,肖喜泉,董威,等.罗汉果祛痰作用谱效关系研究[J].广西植物,2017,37(5):606-609.
[20]WANG Y,LIN Z,ZHANG B,et al.Cichorium intybus L.promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia[J].Nutr Metrb,2017,14(1):38.
[21]姚兰,焦安妮,冯琳琳,等.大叶冬青药材的黄嘌呤氧化酶抑制作用的谱效关系研究[J].中草药,2018,49(20):4838-4843.
[22]方健,吴晓宁,蒋剑平,等.常山胡柚皮黄酮类成分指纹图谱与其抗氧化活性的谱效关系研究[J].中国现代应用药学,2018,35(10):1489-1493.
[23]ZHANG S,SHAO S Y,SONG X Y,et al.Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity[J].Neurotoxicology,2016,52:72-83.
[24]YAN J Y,XIE G X,LIANG C G,et al.Herbal medicine Yinchenhaotang protects againstα-naphthylisothiocyanate-induced cholestasis in rats[J].Sci Res,2017,7(1):4211.
[25]陈心悦,柳小亚,陈亚丽,等.红芪药材防治肝纤维化的谱效关系[J].色谱,2015,33(4):413-418.
[26]洪妍,刘小花,陈亚丽,等.多指标综合评价黄芪免疫活性的谱效相关性[J].药学学报,2017,52(5):785-789.
[27]池婕,林兵,刘志宏,等.雷公藤制剂指纹图谱及谱效关系研究[J].中国中药杂志,2015,40(8):1479-1483.
[28]陈宇,薛志远,师志强,等.红芪活性组分抗骨质疏松作用的谱效关系研究[J].中草药,2018,49(1):160-166.
[29]XIAO N,LOU M D,LU Y T,et al.Ginsenoside Rg5attenuates hepatic glucagon response via suppression of succinate-associated HIF-1αinduction in HFD-fed mice[J].Diabetologia,2017,60(6):1084-1093.
[30]高婧,徐宝欣,赵胜男,等.山楂叶提取物HPLC指纹图谱归属分析及谱效关系初探[J].中药材,2017,40(12):2882-2886.
[31]伍珊娜,刘振杰,章从恩,等.基于谱效关系的灯盏细辛体外抗血小板聚集活性成分研究[J].中草药,2017,48(24):5179-5185.
[32]CHEN Y,YU H,WU H,et al.Tracing novel hemostatic compounds from heating products of total flavonoids in Flos Sophorae by spectrum-effect relationships and column chromatography[J].J Sep Sci,2015,38(10):1691-1699.
[33]郭谦亮,张天华,王宁,等.玛咖不同提取部位对磷酸二酯酶5抑制作用的谱-效关系[J].中草药,2017,48(4):728-736.
[34]DAN Y,PENG W,LIU Y,et al.Spectrum-effect relationships between high performance liquid chromatography fingerprints and bioactivities of charred areca nut[J].Trop J Pharm Res,2016,15(5):1017-1024.
[35]陈洋,梁健,董伟,等.基于谱-效相关分析的吴茱萸止呕药效物质的初步研究[J].药学学报,2017,52(11):1737-1742.
[36]吴启端.谱效研究结合偏最小二乘法在石菖蒲挥发油有效成分筛选中的应用[J].中药新药与临床药理,2018,29(4):497-501.
[37]LI W,SUN X,LIU B,et al.Screening and identification of hepatotoxic component in Evodia rutaecarpa based on spectrumeffect relationship and UPLC-Q-TOFMS[J].Biomed Chromatogr,2016,30(12):1975-1983.
[2]SHENG Z C,LIN Z J,XIAO M L,et al.The spectrum-effect relationship-a rational approach to screening effective compounds,reflecting the internal quality of Chinese herbal medicine[J].Chin JNat Med,2016,14(3):177-184.
[3]吕邵娃,杨阳,赵爽,等.线叶菊抗耐药性细菌感染有效部位的抗菌活性谱效关系[J].中国实验方剂学杂志,2017,23(24):84-89.
[4]LIAO S G,ZHANG L J,SUN F,et al.Identification and characterisation of phenolics in Polygonum capitatum by ultra highperformance liquid chromatography with photodiode array detection and tandem mass spectrometry[J].Phytochem Anal,2013,24(6):556-568.
[5]SHI Z L,LIU Z J,LIU C S,et al.Spectrum-effect relationships between chemical fingerprints and antibacterial effects of Lonicerae japonicae flos and Lonicerae flos base on UPLC and microcalorimetry[J].Front Pharmacol,2016,7:12.
[6]闫峻,刘舒,李伯平,等.基于复方板蓝根颗粒APCI-MS指纹图谱及化学成分的LC-APCI-MSn研究[J].质谱学报,2017,38(3):320-327.
[7]SUN Y,XUE J,LI B,et al.Simultaneous quantification of triterpenoid saponins in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study after oral total saponin of Aralia elata leaves[J].J Sep Sci,2016,39(22):4360-4368.
[8]WANG G,YAO S,CHENG L,et al.Antioxidant and anticancer effection of the volatile oil from various habitats of Selaginella doederleinii Hieron[J].Technol Health Care,2015,23(suppl 1):s21.
[9]樊佳新,包永睿,孟宪生,等.基于微流控芯片技术的荆芥不同药用部位抗肺肿瘤药效关系研究[J].中国中药杂志,2017,42(9):1717-1721.
[10]WANG Y,LI Y,ZHANG Y,et al.Multi-dimensional spectrumeffect relationship of the impact of Chinese herbal formula Lichong Shengsui Yin on ovarian cancer[J].Molecules,2017,22(6):979.
[11]WANG Y L,HU G,ZHANG Q,et al.Screening and characterizing tyrosinase inhibitors from Salvia miltiorrhiza and Carthamus tinctorius by spectrum-effect relationship analysis and molecular docking[J].J Anal Methods Chem,2018,2018:2141389.DOI:10.1155/2018/2141389.
[12]卿勇军,刘文,杜平,等.基于灰色关联度分析戊己丸对胃蛋白酶抑制作用的谱效关系[J].中草药,2017,48(16):3390-3395.
[13]LYU S,DONG S,XU D,et al.Spectrum-effect relationships between fingerprints of Caulophyllum robustum Maxim and inhabited pro-inflammation cytokine effects[J].Molecules,2017,22(11):1826.
[14]WANG C W,FANG X H.Protective effect of rhamnopyranosyl vanilloyl isolated from Scrophularia ningpoensis Hemsl(Scrophulariaceae)root against acute liver injury in mice[J].Trop J Pharm Res,2016,15(7):1499-1505.
[15]ZHANG Q,LEI H M,WANG P L,et al.Bioactive components from Qingwen Baidu Decoction against LPS-induced acute lung injury in rats[J].Molecules,2017,22(5):692.
[16]LEE S E,LIM C,KIM H,et al.A study of the anti-inflammatory effects of the ethyl acetate fraction of the methanol extract of Forsythiae fructus[J].Afr J Tradit Complem,2016,13(5):102-113.
[17]毛艳,贺金华,蔡晓翠,等.维药神香草提取物体外抗炎作用的谱效关系研究[J].中国药房,2017,28(10):1364-1367.
[18]JIANG Y B,ZHONG M,HU M X,et al.Spectrum-effect relationships between high performance iquid chromatography fingerprint and analgesic property of Anisodus tanguticus(Maxim)Pascher(Solanaceae)roots[J].Trop J Pharm Res,2017,16(2):379-386.
[19]王勤,肖喜泉,董威,等.罗汉果祛痰作用谱效关系研究[J].广西植物,2017,37(5):606-609.
[20]WANG Y,LIN Z,ZHANG B,et al.Cichorium intybus L.promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia[J].Nutr Metrb,2017,14(1):38.
[21]姚兰,焦安妮,冯琳琳,等.大叶冬青药材的黄嘌呤氧化酶抑制作用的谱效关系研究[J].中草药,2018,49(20):4838-4843.
[22]方健,吴晓宁,蒋剑平,等.常山胡柚皮黄酮类成分指纹图谱与其抗氧化活性的谱效关系研究[J].中国现代应用药学,2018,35(10):1489-1493.
[23]ZHANG S,SHAO S Y,SONG X Y,et al.Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity[J].Neurotoxicology,2016,52:72-83.
[24]YAN J Y,XIE G X,LIANG C G,et al.Herbal medicine Yinchenhaotang protects againstα-naphthylisothiocyanate-induced cholestasis in rats[J].Sci Res,2017,7(1):4211.
[25]陈心悦,柳小亚,陈亚丽,等.红芪药材防治肝纤维化的谱效关系[J].色谱,2015,33(4):413-418.
[26]洪妍,刘小花,陈亚丽,等.多指标综合评价黄芪免疫活性的谱效相关性[J].药学学报,2017,52(5):785-789.
[27]池婕,林兵,刘志宏,等.雷公藤制剂指纹图谱及谱效关系研究[J].中国中药杂志,2015,40(8):1479-1483.
[28]陈宇,薛志远,师志强,等.红芪活性组分抗骨质疏松作用的谱效关系研究[J].中草药,2018,49(1):160-166.
[29]XIAO N,LOU M D,LU Y T,et al.Ginsenoside Rg5attenuates hepatic glucagon response via suppression of succinate-associated HIF-1αinduction in HFD-fed mice[J].Diabetologia,2017,60(6):1084-1093.
[30]高婧,徐宝欣,赵胜男,等.山楂叶提取物HPLC指纹图谱归属分析及谱效关系初探[J].中药材,2017,40(12):2882-2886.
[31]伍珊娜,刘振杰,章从恩,等.基于谱效关系的灯盏细辛体外抗血小板聚集活性成分研究[J].中草药,2017,48(24):5179-5185.
[32]CHEN Y,YU H,WU H,et al.Tracing novel hemostatic compounds from heating products of total flavonoids in Flos Sophorae by spectrum-effect relationships and column chromatography[J].J Sep Sci,2015,38(10):1691-1699.
[33]郭谦亮,张天华,王宁,等.玛咖不同提取部位对磷酸二酯酶5抑制作用的谱-效关系[J].中草药,2017,48(4):728-736.
[34]DAN Y,PENG W,LIU Y,et al.Spectrum-effect relationships between high performance liquid chromatography fingerprints and bioactivities of charred areca nut[J].Trop J Pharm Res,2016,15(5):1017-1024.
[35]陈洋,梁健,董伟,等.基于谱-效相关分析的吴茱萸止呕药效物质的初步研究[J].药学学报,2017,52(11):1737-1742.
[36]吴启端.谱效研究结合偏最小二乘法在石菖蒲挥发油有效成分筛选中的应用[J].中药新药与临床药理,2018,29(4):497-501.
[37]LI W,SUN X,LIU B,et al.Screening and identification of hepatotoxic component in Evodia rutaecarpa based on spectrumeffect relationship and UPLC-Q-TOFMS[J].Biomed Chromatogr,2016,30(12):1975-1983.