从“邪伏少阴”探讨系统性红斑狼疮的发病机制与临床辨治
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摘要
基于"邪伏少阴"理论探讨系统性红斑狼疮的病因、发病机制、病程特点以及临床症状,认为其病邪性质以热毒为主,与瘀血、痰饮相关,由于肾精亏虚,病邪乘虚内伏,因热毒引动或正气亏虚而伺机发作。系统性红斑狼疮的治疗根据急性期和缓解期分阶段论治,急性发作以祛邪为主,病情缓解则以补虚为主,同时需明辨热、痰、瘀之盛,治以清透热毒法、活血祛瘀法、涤痰蠲饮法和滋肾益阴法。
This paper discusses about the etiology, pathogenesis, course characteristics and clinical symptoms of systemic lupus erythematosus(SLE) based on the theory of ‘pathogen lodging in Shaoyin'. The pathogenic nature of SLE's is mainly heat-toxicity, which is related to blood stasis and phlegm-fluid retention. The pathogen of SLE is lodging in due to deficiency of kidney essence and might be emerging at some time induced by heat-toxicity or qi deficiency. The treatment of SLE often depends on its stages, including acute stage and remission stage. Acute stage of SLE needs the treatment of dispelling pathogenic factors, while remission stage of SLE needs the treatment of tonifying deficiency. At the same time, it is necessary to distinguish between heat, phlegm and blood stasis, and treat them by clearing away heat and toxin, activating blood circulation and dispelling blood stasis, clearing up phlegm and removing rheum and nourishing the kidney and boosting yin.
This paper discusses about the etiology, pathogenesis, course characteristics and clinical symptoms of systemic lupus erythematosus(SLE) based on the theory of ‘pathogen lodging in Shaoyin'. The pathogenic nature of SLE's is mainly heat-toxicity, which is related to blood stasis and phlegm-fluid retention. The pathogen of SLE is lodging in due to deficiency of kidney essence and might be emerging at some time induced by heat-toxicity or qi deficiency. The treatment of SLE often depends on its stages, including acute stage and remission stage. Acute stage of SLE needs the treatment of dispelling pathogenic factors, while remission stage of SLE needs the treatment of tonifying deficiency. At the same time, it is necessary to distinguish between heat, phlegm and blood stasis, and treat them by clearing away heat and toxin, activating blood circulation and dispelling blood stasis, clearing up phlegm and removing rheum and nourishing the kidney and boosting yin.
引文
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[7]杨爽,韩玉萍,崔莉.312例系统性红斑狼疮复发因素分析及对策.山东医药,2008(11):100
[8]谭焕源.68例系统性红斑狼疮复发因素临床分析.当代医学,2012,18(16):72-73
[9]丁翔,孙凌云,张缪佳,等.系统性红斑狼疮浆膜炎临床分析.江苏医药,2011,37(5):552-553
[10]石锐,孟文宜,王国强,等.痰瘀伏邪与冠心病心衰心功能分级、N端前脑钠素及心脏超声指标相关性研究.中国中医急症,2017,26(5):779-782
[11]翟文生,高旭光.从“热、毒、瘀”结合体质特点辨治小儿狼疮性肾炎.中医杂志,2011,52(2):102-103,117
[3]巩振东,李翠娟,刘子瑄,等.“正常体质-肾虚体质-肾虚证候”唾液代谢组学研究.中华中医药杂志,2017,32(11):5084-5087
[4]辛文瀚,冷平,庞博,等.肾虚证候相关检验医学指标的筛选.中医杂志,2016,57(16):1402-1405
[5]兰访,韦慧萍,朱璇,等.系统性红斑狼疮补体C3、C4水平与其他相关实验指标的相关性研究.广西医科大学学报,2016,33(6):989-992
[6]冯莉霞,杨金水,裴蕾,等.系统性红斑狼疮复发患者临床特点回顾分析.中国实用内科杂志,2015,35(10):848-851
[7]杨爽,韩玉萍,崔莉.312例系统性红斑狼疮复发因素分析及对策.山东医药,2008(11):100
[8]谭焕源.68例系统性红斑狼疮复发因素临床分析.当代医学,2012,18(16):72-73
[9]丁翔,孙凌云,张缪佳,等.系统性红斑狼疮浆膜炎临床分析.江苏医药,2011,37(5):552-553
[10]石锐,孟文宜,王国强,等.痰瘀伏邪与冠心病心衰心功能分级、N端前脑钠素及心脏超声指标相关性研究.中国中医急症,2017,26(5):779-782
[11]翟文生,高旭光.从“热、毒、瘀”结合体质特点辨治小儿狼疮性肾炎.中医杂志,2011,52(2):102-103,117