生产性粉尘接触与慢性阻塞性肺疾病关系研究进展
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摘要
<正>生产性粉尘是指在人类的生产活动中产生的能够较长时间漂浮于生产环境中的固体微颗粒,其是污染作业环境、损害劳动者健康的主要职业性有害因素,可引起包括职业性尘肺病在内的多种职业性肺部疾病[1]。慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是一种可防治的肺部疾病,其以持续呼吸症状和气流受限为特征,通常是由于接触有毒颗粒或气体引起的气道和肺泡异常所致。慢性气流受限是COPD的特征,由小
引文
[1] 邬堂春.职业卫生与职业医学[M].8版.北京:人民卫生出版社,2017:181.
[2] VOGELMEIER C F, CRINER G J, MARTNEZ F J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report: GOLD executive summary[J]. Arch Bronconeumol,2017,53(3):128-149.
[3] MATHERS C D, LONCAR D. Projections of global mortality and burden of disease from 2002 to 2030[J]. PLoS Med,2006,3(11):e442.
[4] KOH D H, KIM J I, KIM K H, et al. Welding fume exposure and chronic obstructive pulmonary disease in welders[J]. Occup Med (Lond),2015,65(1):72-77.
[5] 房艳红,张晓乐.天津市武清区COPD死亡病例相关危险因素的Logistic回归分析[J].医学信息,2017,30(21):42-43.
[6] 覃善芳,张庆团,张凯.慢性阻塞性肺疾病发病相关危险因素Logistic回归分析[J].中华全科医学,2013,11(4):597,662.
[7] HANSELL A, GHOSH R E, POOLE S, et al. Occupational risk factors for chronic respiratory disease in a New Zealand population using lifetime occupational history[J]. J Occup Environ Med,2014,56(3):270-280.
[8] DIJKSTRA A E, de JONG K, BOEZEN H M, et al. Risk factors for chronic mucus hypersecretion in individuals with and without COPD: influence of smoking and job exposure on CMH[J]. Occup Environ Med,2014,71(5):346-352.
[9] REYNOLDS C J, MACNEILL S J, WILLIAMS J, et al. Chronic obstructive pulmonary disease in Welsh slate miners[J]. Occup Med (Lond),2017,67(1):20-25.
[10] BRSKE I, THIERING E, HEINRICH J, et al. Respirable quartz dust exposure and airway obstruction: a systematic review and meta-analysis[J]. Occup Environ Med,2014,71(8):583-589.
[11] MHNER M, KERSTEN N, GELLISSEN J. Chronic obstructive pulmonary disease and longitudinal changes in pulmonary function due to occupational exposure to respirable quartz[J]. Occup Environ Med,2013,70(1):9-14.
[12] VINNIKOV D, SEMIZHON S, RYBINA T, et al. Occupation and chronic obstructive pulmonary disease in Minsk tractor plant workers[J]. Am J Ind Med,2017,60(12):1049-1055.
[13] BALA S, TABAKU A. Chronic obstructive pulmonary disease in iron-steel and ferrochrome industry workers[J]. Cent Eur J Public Health,2010,18(2):93-98.
[14] 汪永忠,王青,耿全,等.生产性粉尘职业接触限值应用问题探讨[J].中国职业医学,2016,43(2):237-240.
[15] MWAISELAGE J, BRTVEIT M, MOEN B E, et al. Respiratory symptoms and chronic obstructive pulmonary disease among cement factory workers[J]. Scand J Work Environ Health,2005,31(4):316-323.
[16] 周玉民,王辰,姚婉贞,等.职业接触粉尘和烟雾对慢性阻塞性肺疾病及呼吸道症状的影响[J].中国呼吸与危重监护杂志,2009,8(1):6-11.
[17] M?LGAARD E F, HANNERZ H, TCHSEN F, et al. Chronic lower respiratory diseases among demolition and cement workers: a population-based register study[J]. BMJ Open,2013,3(1). doi:10.1136/bmjopen-2012-001938.
[18] NORDBY K C, FELL A K, NOT?H, et al. Exposure to thoracic dust, airway symptoms and lung function in cement production workers[J]. Eur Respir J,2011,38(6):1278-1286.
[19] MEHTA A J, MIEDINGER D, KEIDEL D, et al. Occupational exposure to dusts, gases, and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults[J]. Am J Respir Crit Care Med,2012,185(12):1292-1300.
[20] GOVENDER N, LALLOO U G, NAIDOO R N. Occupational exposures and chronic obstructive pulmonary disease: a hospital based case-control study[J]. Thorax,2011,66(7):597-601.
[21] RODRIGUEZ E, FERRER J, MART S, et al. Impact of occupational exposure on severity of COPD[J]. Chest,2008,134(6):1237-1243.
[22] LYTRAS T, KOGEVINAS M, KROMHOUT H, et al. Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey[J]. Thorax,2018:thoraxjnl-2017-211158. doi:10.1136/thoraxjnl-2017-211158.
[23] TAGIYEVA N, SADHRA S, MOHAMMED N, et al. Occupational airborne exposure in relation to Chronic Obstructive Pulmonary Disease (COPD) and lung function in individuals without childhood wheezing illness: a 50-year cohort study[J]. Environ Res,2017,153:126-134.
[24] MASTRANGELO G, TARTARI M, FEDELI U, et al. Ascertaining the risk of chronic obstructive pulmonary disease in relation to occupation using a case-control design[J]. Occup Med (Lond),2003,53(3):165-172.
[25] CUI L, GALLAGHER L G, RAY R M, et al. Unexpected excessive chronic obstructive pulmonary disease mortality among female silk textile workers in Shanghai, China[J]. Occup Environ Med,2011,68(12):883-887.
[26] LEVAN T D, KOH W P, LEE H P, et al. Vapor, dust, and smoke exposure in relation to adult-onset asthma and chronic respiratory symptoms: the Singapore Chinese Health Study[J]. Am J Epidemiol,2006,163(12):1118-1128.
[27] BERGDAHL I A, TORN K, ERIKSSON K, et al. Increased mortality in COPD among construction workers exposed to inorganic dust[J]. Eur Respir J,2004,23(3):402-406.
[28] BARAN S, SWIETLIK K, TEUL I. Lung function: occupational exposure to wood dust[J]. Eur J Med Res,2009,14(Suppl 4):14-17.
[29] BORM P J, JETTEN M, HIDAYAT S, et al. Respiratory symptoms, lung function, and nasal cellularity in Indonesian wood workers: a dose-response analysis[J]. Occup Environ Med,2002,59(5):338-344.
[30] LAI P S, CHRISTIANI D C. Long-term respiratory health effects in textile workers[J]. Curr Opin Pulm Med,2013,19(2):152-157.
[31] 李立明.流行病学[M].3版.北京:人民卫生出版社,2014:398.
[32] PAN X, JI Z, XUE J. Percentage of peripheral CD19+CD24hiCD38hi regulatory B cells in neonatal sepsis patients and its functional implication[J]. Med Sci Monit,2016,22:2374-2378.
[33] JANOFF A. Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis[J]. Am Rev Respir Dis,1985,132(2):417-433.
[34] ZHAO Y L, LI F, LIU Y W, et al. Adiponectin attenuates endoplasmic reticulum stress and alveolar epithelial apoptosis in COPD rats[J]. Eur Rev Med Pharmacol Sci,2017,21(21):4999-5007.
[35] DEY T, GOGOI K, UNNI B G, et al. Role of glutathione S transferase polymorphism in COPD with special reference to peoples living in the vicinity of the open cast coal mine of Assam[J]. PLoS One,2014,9(5):e96739.
[36] 赵淑岚.二氧化硅粉尘检测与评价中的问题探讨[J].中国工业医学杂志,2016,29(5):391-392.
[37] FIGUEIR F, MULLER L, FUNK S, et al. Phenotypic and functional characteristics of CD39high human regulatory B cells (Breg)[J]. Oncoimmunology,2016,5(2):e1082703.
[38] BOUAZIZ J D, LE BUANEC H, SAUSSINE A, et al. IL-10 producing regulatory B cells in mice and humans: state of the art[J]. Curr Mol Med,2012,12(5):519-527.
[39] LU Y, LIU F, LI C, et al. IL-10-producing B cells suppress effector T cells activation and promote regulatory T cells in crystalline silica-induced inflammatory response in vitro[J]. Mediators Inflamm,2017:8415094. doi:10.1155/2017/8415094.
[40] 王成阳,刘向国,王传博,等.COPD大鼠T细胞介导转录因子对Th1/Th2细胞调控的实验研究[J].四川大学学报(医学版),2014,45(6):941-945.
[41] 廖静,李小峰,王春香.矽尘致工人FOXP3DNA甲基化改变的研究[J].职业与健康,2018,34(2):162-166.
[42] ZAY K, DEVINE D, CHURG A. Quartz inactivates alpha 1-antiproteinase: possible role in mineral dust-induced emphysema[J]. J Appl Physiol (1985),1995,78(1):53-58.
[43] CHURG A, ZAY K, LI K. Mechanisms of mineral dust-induced emphysema[J]. Environ Health Perspect,1997,105(Suppl 5):1215-1218.
[44] COHEN M D, SISCO M, BAKER K, et al. Rapid communication: effect of inhaled chromium on pulmonary A1AT[J]. Inhal Toxicol,2002,14(7):765-771.
[45] MIZUMURA K, CLOONAN S M, HASPEL J A, et al. The emerging importance of autophagy in pulmonary diseases[J]. Chest,2012,142(5):1289-1299.
[46] 余静,徐圆媛,陈立立,等.3-硝基酪氨酸对HepG2细胞氧化还原状态的影响[J].中国细胞生物学学报,2014,36(4):509-515.
[47] LEE J S, SHIN J H, HWANG J H, et al. Malondialdehyde and 3-nitrotyrosine in exhaled breath condensate in retired elderly coal miners with chronic obstructive pulmonary disease[J]. Saf Health Work,2014,5(2):91-96.
[48] GUILLIEN A, PUYRAVEAU M, SOUMAGNE T, et al. Prevalence and risk factors for COPD in farmers: a cross-sectional controlled study[J]. Eur Respir J,2016,47(1), 95-103.
[49] PFISTER H, MORZADEC C, Le CANN P, et al. Granulometry, microbial composition and biological activity of dusts collected in French dairy farms[J]. Environ Res,2017,158:691-702.
[50] 钱文君,房鹏,顾宗江.IL-1β、IL-6、IL-8、TNF-α在慢性阻塞性肺病中的表达[J].实用临床医药杂志,2015,19(15):172-173,183.
[51] PAULIN L M, DIETTE G B, BLANC P D, et al. Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med,2015,191(5):557-565.
[52] 方利文,王临虹.中国居民慢性阻塞性肺疾病监测意义重大[J].中华流行病学杂志,2018,39(5):541-545.
[2] VOGELMEIER C F, CRINER G J, MARTNEZ F J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report: GOLD executive summary[J]. Arch Bronconeumol,2017,53(3):128-149.
[3] MATHERS C D, LONCAR D. Projections of global mortality and burden of disease from 2002 to 2030[J]. PLoS Med,2006,3(11):e442.
[4] KOH D H, KIM J I, KIM K H, et al. Welding fume exposure and chronic obstructive pulmonary disease in welders[J]. Occup Med (Lond),2015,65(1):72-77.
[5] 房艳红,张晓乐.天津市武清区COPD死亡病例相关危险因素的Logistic回归分析[J].医学信息,2017,30(21):42-43.
[6] 覃善芳,张庆团,张凯.慢性阻塞性肺疾病发病相关危险因素Logistic回归分析[J].中华全科医学,2013,11(4):597,662.
[7] HANSELL A, GHOSH R E, POOLE S, et al. Occupational risk factors for chronic respiratory disease in a New Zealand population using lifetime occupational history[J]. J Occup Environ Med,2014,56(3):270-280.
[8] DIJKSTRA A E, de JONG K, BOEZEN H M, et al. Risk factors for chronic mucus hypersecretion in individuals with and without COPD: influence of smoking and job exposure on CMH[J]. Occup Environ Med,2014,71(5):346-352.
[9] REYNOLDS C J, MACNEILL S J, WILLIAMS J, et al. Chronic obstructive pulmonary disease in Welsh slate miners[J]. Occup Med (Lond),2017,67(1):20-25.
[10] BRSKE I, THIERING E, HEINRICH J, et al. Respirable quartz dust exposure and airway obstruction: a systematic review and meta-analysis[J]. Occup Environ Med,2014,71(8):583-589.
[11] MHNER M, KERSTEN N, GELLISSEN J. Chronic obstructive pulmonary disease and longitudinal changes in pulmonary function due to occupational exposure to respirable quartz[J]. Occup Environ Med,2013,70(1):9-14.
[12] VINNIKOV D, SEMIZHON S, RYBINA T, et al. Occupation and chronic obstructive pulmonary disease in Minsk tractor plant workers[J]. Am J Ind Med,2017,60(12):1049-1055.
[13] BALA S, TABAKU A. Chronic obstructive pulmonary disease in iron-steel and ferrochrome industry workers[J]. Cent Eur J Public Health,2010,18(2):93-98.
[14] 汪永忠,王青,耿全,等.生产性粉尘职业接触限值应用问题探讨[J].中国职业医学,2016,43(2):237-240.
[15] MWAISELAGE J, BRTVEIT M, MOEN B E, et al. Respiratory symptoms and chronic obstructive pulmonary disease among cement factory workers[J]. Scand J Work Environ Health,2005,31(4):316-323.
[16] 周玉民,王辰,姚婉贞,等.职业接触粉尘和烟雾对慢性阻塞性肺疾病及呼吸道症状的影响[J].中国呼吸与危重监护杂志,2009,8(1):6-11.
[17] M?LGAARD E F, HANNERZ H, TCHSEN F, et al. Chronic lower respiratory diseases among demolition and cement workers: a population-based register study[J]. BMJ Open,2013,3(1). doi:10.1136/bmjopen-2012-001938.
[18] NORDBY K C, FELL A K, NOT?H, et al. Exposure to thoracic dust, airway symptoms and lung function in cement production workers[J]. Eur Respir J,2011,38(6):1278-1286.
[19] MEHTA A J, MIEDINGER D, KEIDEL D, et al. Occupational exposure to dusts, gases, and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults[J]. Am J Respir Crit Care Med,2012,185(12):1292-1300.
[20] GOVENDER N, LALLOO U G, NAIDOO R N. Occupational exposures and chronic obstructive pulmonary disease: a hospital based case-control study[J]. Thorax,2011,66(7):597-601.
[21] RODRIGUEZ E, FERRER J, MART S, et al. Impact of occupational exposure on severity of COPD[J]. Chest,2008,134(6):1237-1243.
[22] LYTRAS T, KOGEVINAS M, KROMHOUT H, et al. Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey[J]. Thorax,2018:thoraxjnl-2017-211158. doi:10.1136/thoraxjnl-2017-211158.
[23] TAGIYEVA N, SADHRA S, MOHAMMED N, et al. Occupational airborne exposure in relation to Chronic Obstructive Pulmonary Disease (COPD) and lung function in individuals without childhood wheezing illness: a 50-year cohort study[J]. Environ Res,2017,153:126-134.
[24] MASTRANGELO G, TARTARI M, FEDELI U, et al. Ascertaining the risk of chronic obstructive pulmonary disease in relation to occupation using a case-control design[J]. Occup Med (Lond),2003,53(3):165-172.
[25] CUI L, GALLAGHER L G, RAY R M, et al. Unexpected excessive chronic obstructive pulmonary disease mortality among female silk textile workers in Shanghai, China[J]. Occup Environ Med,2011,68(12):883-887.
[26] LEVAN T D, KOH W P, LEE H P, et al. Vapor, dust, and smoke exposure in relation to adult-onset asthma and chronic respiratory symptoms: the Singapore Chinese Health Study[J]. Am J Epidemiol,2006,163(12):1118-1128.
[27] BERGDAHL I A, TORN K, ERIKSSON K, et al. Increased mortality in COPD among construction workers exposed to inorganic dust[J]. Eur Respir J,2004,23(3):402-406.
[28] BARAN S, SWIETLIK K, TEUL I. Lung function: occupational exposure to wood dust[J]. Eur J Med Res,2009,14(Suppl 4):14-17.
[29] BORM P J, JETTEN M, HIDAYAT S, et al. Respiratory symptoms, lung function, and nasal cellularity in Indonesian wood workers: a dose-response analysis[J]. Occup Environ Med,2002,59(5):338-344.
[30] LAI P S, CHRISTIANI D C. Long-term respiratory health effects in textile workers[J]. Curr Opin Pulm Med,2013,19(2):152-157.
[31] 李立明.流行病学[M].3版.北京:人民卫生出版社,2014:398.
[32] PAN X, JI Z, XUE J. Percentage of peripheral CD19+CD24hiCD38hi regulatory B cells in neonatal sepsis patients and its functional implication[J]. Med Sci Monit,2016,22:2374-2378.
[33] JANOFF A. Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis[J]. Am Rev Respir Dis,1985,132(2):417-433.
[34] ZHAO Y L, LI F, LIU Y W, et al. Adiponectin attenuates endoplasmic reticulum stress and alveolar epithelial apoptosis in COPD rats[J]. Eur Rev Med Pharmacol Sci,2017,21(21):4999-5007.
[35] DEY T, GOGOI K, UNNI B G, et al. Role of glutathione S transferase polymorphism in COPD with special reference to peoples living in the vicinity of the open cast coal mine of Assam[J]. PLoS One,2014,9(5):e96739.
[36] 赵淑岚.二氧化硅粉尘检测与评价中的问题探讨[J].中国工业医学杂志,2016,29(5):391-392.
[37] FIGUEIR F, MULLER L, FUNK S, et al. Phenotypic and functional characteristics of CD39high human regulatory B cells (Breg)[J]. Oncoimmunology,2016,5(2):e1082703.
[38] BOUAZIZ J D, LE BUANEC H, SAUSSINE A, et al. IL-10 producing regulatory B cells in mice and humans: state of the art[J]. Curr Mol Med,2012,12(5):519-527.
[39] LU Y, LIU F, LI C, et al. IL-10-producing B cells suppress effector T cells activation and promote regulatory T cells in crystalline silica-induced inflammatory response in vitro[J]. Mediators Inflamm,2017:8415094. doi:10.1155/2017/8415094.
[40] 王成阳,刘向国,王传博,等.COPD大鼠T细胞介导转录因子对Th1/Th2细胞调控的实验研究[J].四川大学学报(医学版),2014,45(6):941-945.
[41] 廖静,李小峰,王春香.矽尘致工人FOXP3DNA甲基化改变的研究[J].职业与健康,2018,34(2):162-166.
[42] ZAY K, DEVINE D, CHURG A. Quartz inactivates alpha 1-antiproteinase: possible role in mineral dust-induced emphysema[J]. J Appl Physiol (1985),1995,78(1):53-58.
[43] CHURG A, ZAY K, LI K. Mechanisms of mineral dust-induced emphysema[J]. Environ Health Perspect,1997,105(Suppl 5):1215-1218.
[44] COHEN M D, SISCO M, BAKER K, et al. Rapid communication: effect of inhaled chromium on pulmonary A1AT[J]. Inhal Toxicol,2002,14(7):765-771.
[45] MIZUMURA K, CLOONAN S M, HASPEL J A, et al. The emerging importance of autophagy in pulmonary diseases[J]. Chest,2012,142(5):1289-1299.
[46] 余静,徐圆媛,陈立立,等.3-硝基酪氨酸对HepG2细胞氧化还原状态的影响[J].中国细胞生物学学报,2014,36(4):509-515.
[47] LEE J S, SHIN J H, HWANG J H, et al. Malondialdehyde and 3-nitrotyrosine in exhaled breath condensate in retired elderly coal miners with chronic obstructive pulmonary disease[J]. Saf Health Work,2014,5(2):91-96.
[48] GUILLIEN A, PUYRAVEAU M, SOUMAGNE T, et al. Prevalence and risk factors for COPD in farmers: a cross-sectional controlled study[J]. Eur Respir J,2016,47(1), 95-103.
[49] PFISTER H, MORZADEC C, Le CANN P, et al. Granulometry, microbial composition and biological activity of dusts collected in French dairy farms[J]. Environ Res,2017,158:691-702.
[50] 钱文君,房鹏,顾宗江.IL-1β、IL-6、IL-8、TNF-α在慢性阻塞性肺病中的表达[J].实用临床医药杂志,2015,19(15):172-173,183.
[51] PAULIN L M, DIETTE G B, BLANC P D, et al. Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med,2015,191(5):557-565.
[52] 方利文,王临虹.中国居民慢性阻塞性肺疾病监测意义重大[J].中华流行病学杂志,2018,39(5):541-545.