丹参与西药相互作用的研究进展
|
摘要
丹参作为传统中药,具有多成分多靶点的特点,药理作用广泛,临床上经常与它药合用。笔者以丹参为例对中西药间相互作用及临床上中西药联用情况等方面进行综述,为丹参的合理应用及中西药相互作用的深入研究提供参考依据。
Salvia miltiorrhiza is a traditional Chinese medicine with multi-component and multi-target features,has a wide range of pharmacological effects and often combined with other drugs in clinical use. In this paper,we used Salvia miltiorrhiza as an example to analyze the combination of Chinese and western medicine in clinic use,and drug interactions. It provide a solid basis for the rational use of Salvia miltiorrhiza,and provide a reference for further research of interactions between Chinese and western medicine.
Salvia miltiorrhiza is a traditional Chinese medicine with multi-component and multi-target features,has a wide range of pharmacological effects and often combined with other drugs in clinical use. In this paper,we used Salvia miltiorrhiza as an example to analyze the combination of Chinese and western medicine in clinic use,and drug interactions. It provide a solid basis for the rational use of Salvia miltiorrhiza,and provide a reference for further research of interactions between Chinese and western medicine.
引文
[1]刘微.丹参多酚酸盐对冠心病稳定性心绞痛患者血液流变学影响的临床研究[J].中国实用医药,2016,11(1):106-107.
[2]侯阿芳,曾伟林,甘礼社.丹参新酮C环酚酯衍生物的设计合成及抗肿瘤活性研究[J].中国现代应用药学,2016,33(11):1396-1402
[3]郭晓红,刘立新,张东梅,等.丹参酮ⅡA对损伤细胞的保护作用及活化肝星状细胞的抑制作用[J].中国药物与临床,2009,9(1):13-17
[4]钱春艳.中西药在吸收及代谢环节的相互作用[J].海峡药学,2007,19(2):109-110.
[5]周聪.中西药不合理联用报道[J].浙江中西医结合杂志,2000,10(10):632-633.
[6]李曼玲,黄枝优.复方丹参注射液与环丙沙星、氧氟沙星注射液存在配伍禁忌[J].中国药师杂志,2002,5(11):659.
[7]覃新地.复方丹参注射液不良反应分析及其配伍禁忌[J].北方药学,2016,13(2):158-159.
[8]戈继业,张振岭,张良芬.中西药相互作用对药物吸收环节的影响[J].中国实用医药,2011,6(36):243-245.
[9]Streubel A,Siepmann J,Bodmeier R.Drug delivery to the upper small intestine window using gastroretentive technologies[J].Curr Opin Pharmacol,2006,6(5):501-508.
[10]Satoh C,Sakai T,Kashiwagi H,et al.Influence of cisapride on the pharmacokinetics and antihypertensive effect of sustained-release nifedipine[J].Intern Med,1996,35(12):941-945.
[11]戈继业,张振岭,张良芬.浅谈中西药物的不合理配伍[J].中级医刊,1997,32(2):60-61.
[12]Liu J,Wang X,Cai Z,et al.Effect of tanshinone IIA on the noncovalent interaction between warfarin and human serum albumin studied by electrospray ionization mass spectrometry[J].J Am Soc Mass Spectrom,2008,19(10):1568-1575.
[13]Jiang X,Blair E Y,Mclachlan A J.Investigation of the effects of herbal medicines on warfarin response in healthy subjects:a population pharmacokinetic pharmaco-dynamic modeling approach[J].J Clin Pharmacol,2005,46(11):1370-1378.
[14]Tao Hu,Xuelin Zhou,Lin Wang,et al.Effects of tanshinones from salvia miltiorrhiza on CYP2C19 activity in human liver microsomes:Enzyme kinetic and molecular docking studies[J].Chemico-Biological Interactions,2015,230:1-8.
[15]于月,殷硕,刘高峰.中药注射剂对细胞色素P450的调控与药物相互作用预测[J].中国药师,2014,17(1):99-103.
[16]Wang X,Cheung C M,Lee W Y,et al.Major tanshinones of Danshen(Salavia miltiorrhiza)exhibit different modes of inhibition on human CYP1A2,CYP2C9,CYP2E1 and CYP3A4 activities in vitro[J].Phytomedicine,2010,17(11):868-875.
[17]施畅,吴纯启,马华智,等.复方丹参滴丸对大鼠肝CYP450酶系诱导作用的研究[J].解放军药学学报,2003,19(5):344-346.
[18]Qiu F,Wang G,Zhang R,et al.Effect of danshen extract on the activity of CYP3A4 in healthy volunteers[J].Br J Clin Pharmacol,2010,69(6):656-662.
[19]Chen Y,Tu J H,He Y J,et al.Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers[J].Xenobiotica,2009,39(7):508-513.
[20]Lo A C,Chan K,Yeung J H,et al.The effects of Danshen(Salvia miltiorrhiza)on pharmacokinetics and pharmacodynamics of warfarin in rats[J].Eur J Drug Metab Pharmacokineti,1992,17(4):257-262.
[21]冯浩,王智民.浅谈中西药配伍中的相互作用[J].中药实验方剂学杂志,2002,8(2):53-55.
[22]谢红娟,付海英,朱彩凤,等.丹参注射液对大鼠体内稳态华法林药动学和药效学参数的影响[J].医药报道,2009,1(28):36-39
[23]Windy W P,JHK.Yeung.Inhibition of warfarin hydroxylation by major tanshinones of Danshen(Salvia miltiorrihiza)in the rat in vitro and in vivo[J].Phytomedicine,2010,17(4):219-226.
[24]宗景义.联用抗生素和黄芪丹参注射液治疗急性盆腔炎的效果观察[J].当代医药论丛,2015,13(15):170-171.
[25]田敬秋.复方丹参注射液和大剂量维生素C治疗急性病毒性心肌炎[J].中国继续医学教育,2015,7(8):257.
[26]李荣,曹序茂,蒋红雨,等.当归、丹参、钙剂对庆大霉素肾损伤防护作用的实验研究[J].贵阳医学院学报,1990,15(3):224-228.
[27]孟和德力格尔,娜仁高娃.丹参与西药的联用[J].内蒙古中医药,2007,26(10):25.
[28]高献荣.非洛地平合用复方丹参注射液治疗慢性肺源性心脏病并心力衰竭的临床观察[J].海峡药学,2015,27(2):135-136.
[29]史丽,李明霞,王立坤,等.复方丹参滴丸联用阿托伐他汀钙治疗2型糖尿病颈动脉硬化的临床疗效[J].江苏大学学报,2016,26(1):74-77.
[30]陈施霖,李国平.门冬氨酸钾镁和复方丹参治疗慢性重度肝炎疗效观察[J].中外健康文摘,2011,28(26):153-154.
[31]张中良.阿德福韦酯联合丹参片治疗乙型肝炎肝纤维化的临床观察[J].临床医学,2014,34(11):79-80.
[32]张芬燕,郭韧,张毕奎.丹参酮ⅡA的心血管药理作用研究进展[J].中国中药杂志,2015,40(9):1649-1653.
[2]侯阿芳,曾伟林,甘礼社.丹参新酮C环酚酯衍生物的设计合成及抗肿瘤活性研究[J].中国现代应用药学,2016,33(11):1396-1402
[3]郭晓红,刘立新,张东梅,等.丹参酮ⅡA对损伤细胞的保护作用及活化肝星状细胞的抑制作用[J].中国药物与临床,2009,9(1):13-17
[4]钱春艳.中西药在吸收及代谢环节的相互作用[J].海峡药学,2007,19(2):109-110.
[5]周聪.中西药不合理联用报道[J].浙江中西医结合杂志,2000,10(10):632-633.
[6]李曼玲,黄枝优.复方丹参注射液与环丙沙星、氧氟沙星注射液存在配伍禁忌[J].中国药师杂志,2002,5(11):659.
[7]覃新地.复方丹参注射液不良反应分析及其配伍禁忌[J].北方药学,2016,13(2):158-159.
[8]戈继业,张振岭,张良芬.中西药相互作用对药物吸收环节的影响[J].中国实用医药,2011,6(36):243-245.
[9]Streubel A,Siepmann J,Bodmeier R.Drug delivery to the upper small intestine window using gastroretentive technologies[J].Curr Opin Pharmacol,2006,6(5):501-508.
[10]Satoh C,Sakai T,Kashiwagi H,et al.Influence of cisapride on the pharmacokinetics and antihypertensive effect of sustained-release nifedipine[J].Intern Med,1996,35(12):941-945.
[11]戈继业,张振岭,张良芬.浅谈中西药物的不合理配伍[J].中级医刊,1997,32(2):60-61.
[12]Liu J,Wang X,Cai Z,et al.Effect of tanshinone IIA on the noncovalent interaction between warfarin and human serum albumin studied by electrospray ionization mass spectrometry[J].J Am Soc Mass Spectrom,2008,19(10):1568-1575.
[13]Jiang X,Blair E Y,Mclachlan A J.Investigation of the effects of herbal medicines on warfarin response in healthy subjects:a population pharmacokinetic pharmaco-dynamic modeling approach[J].J Clin Pharmacol,2005,46(11):1370-1378.
[14]Tao Hu,Xuelin Zhou,Lin Wang,et al.Effects of tanshinones from salvia miltiorrhiza on CYP2C19 activity in human liver microsomes:Enzyme kinetic and molecular docking studies[J].Chemico-Biological Interactions,2015,230:1-8.
[15]于月,殷硕,刘高峰.中药注射剂对细胞色素P450的调控与药物相互作用预测[J].中国药师,2014,17(1):99-103.
[16]Wang X,Cheung C M,Lee W Y,et al.Major tanshinones of Danshen(Salavia miltiorrhiza)exhibit different modes of inhibition on human CYP1A2,CYP2C9,CYP2E1 and CYP3A4 activities in vitro[J].Phytomedicine,2010,17(11):868-875.
[17]施畅,吴纯启,马华智,等.复方丹参滴丸对大鼠肝CYP450酶系诱导作用的研究[J].解放军药学学报,2003,19(5):344-346.
[18]Qiu F,Wang G,Zhang R,et al.Effect of danshen extract on the activity of CYP3A4 in healthy volunteers[J].Br J Clin Pharmacol,2010,69(6):656-662.
[19]Chen Y,Tu J H,He Y J,et al.Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers[J].Xenobiotica,2009,39(7):508-513.
[20]Lo A C,Chan K,Yeung J H,et al.The effects of Danshen(Salvia miltiorrhiza)on pharmacokinetics and pharmacodynamics of warfarin in rats[J].Eur J Drug Metab Pharmacokineti,1992,17(4):257-262.
[21]冯浩,王智民.浅谈中西药配伍中的相互作用[J].中药实验方剂学杂志,2002,8(2):53-55.
[22]谢红娟,付海英,朱彩凤,等.丹参注射液对大鼠体内稳态华法林药动学和药效学参数的影响[J].医药报道,2009,1(28):36-39
[23]Windy W P,JHK.Yeung.Inhibition of warfarin hydroxylation by major tanshinones of Danshen(Salvia miltiorrihiza)in the rat in vitro and in vivo[J].Phytomedicine,2010,17(4):219-226.
[24]宗景义.联用抗生素和黄芪丹参注射液治疗急性盆腔炎的效果观察[J].当代医药论丛,2015,13(15):170-171.
[25]田敬秋.复方丹参注射液和大剂量维生素C治疗急性病毒性心肌炎[J].中国继续医学教育,2015,7(8):257.
[26]李荣,曹序茂,蒋红雨,等.当归、丹参、钙剂对庆大霉素肾损伤防护作用的实验研究[J].贵阳医学院学报,1990,15(3):224-228.
[27]孟和德力格尔,娜仁高娃.丹参与西药的联用[J].内蒙古中医药,2007,26(10):25.
[28]高献荣.非洛地平合用复方丹参注射液治疗慢性肺源性心脏病并心力衰竭的临床观察[J].海峡药学,2015,27(2):135-136.
[29]史丽,李明霞,王立坤,等.复方丹参滴丸联用阿托伐他汀钙治疗2型糖尿病颈动脉硬化的临床疗效[J].江苏大学学报,2016,26(1):74-77.
[30]陈施霖,李国平.门冬氨酸钾镁和复方丹参治疗慢性重度肝炎疗效观察[J].中外健康文摘,2011,28(26):153-154.
[31]张中良.阿德福韦酯联合丹参片治疗乙型肝炎肝纤维化的临床观察[J].临床医学,2014,34(11):79-80.
[32]张芬燕,郭韧,张毕奎.丹参酮ⅡA的心血管药理作用研究进展[J].中国中药杂志,2015,40(9):1649-1653.