大豆异黄酮对骨骼肌发育的影响及其对动物肉品质的调控作用
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摘要
大豆异黄酮是一类植物雌激素,对动物机体的调控作用非常广泛。近年来研究发现,大豆异黄酮对动物的骨骼肌发育有很重要的调控作用。本文综述了大豆异黄酮对肌肉能量与蛋白代谢、肌细胞的增殖与分化以及肌纤维类型转化的影响,并进一步探讨了大豆异黄酮对动物肌肉品质的调控作用。
Soybean isoflavones are a class of phytoestrogens, which have extensive effects on animal body. Recently,numerous studies have found that isoflavones play an important role in the regulation of skeletal muscle development in animals. In this article, we reviewed the effects of isoflavones on skeletal muscle energy and protein metabolism, myoblast proliferation and differentiation, and muscle fiber type transformation, and further explored the regulation of isoflavones on meat quality in animals.
Soybean isoflavones are a class of phytoestrogens, which have extensive effects on animal body. Recently,numerous studies have found that isoflavones play an important role in the regulation of skeletal muscle development in animals. In this article, we reviewed the effects of isoflavones on skeletal muscle energy and protein metabolism, myoblast proliferation and differentiation, and muscle fiber type transformation, and further explored the regulation of isoflavones on meat quality in animals.
引文
[1]许啸,齐智利.大豆异黄酮对畜禽生理机能的调控[J].动物营养学报,2012,24(3):436-438.
[2]Zhang Q,Xie H,Chen D,et al.Dietary daidzein supplementation during pregnancy facilitates fetal growth in rats[J].Mol Nutr Food Res,2018,62(24):1800921.
[3]Lee C H,Yang L,Xu J Z,et al.Relative antioxidant activity of soybean isoflavones and their glycosides[J].Food Chem,2005,90(4):736-741.
[4]Yu J,Bi X,Yu B,et al.Isoflavones:anti-inflammatory benefit and possible caveats[J].Nutrients,2016,8(6):361.
[5]Sakai T,Kogiso M.Soy isoflavones and immunity[J].J Med Invest,2008,55(3,4):167-173.
[6]Lee S J,Vuong T A,Go G Y,et al.An isoflavone compound daidzein elicits myoblast differentiation and myotube growth[J].JFunct Foods,2017,38:438-446.
[7]Cheong S H,Furuhashi K,Ito K,et al.Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice[J].J Nutr Biochem,2014,25(2):136-143.
[8]Mau M,Kalbe C,Viergutz T,et al.Effects of dietary isoflavones on proliferation and DNA integrity of myoblasts derived from newborn piglets[J].Pediatr Res,2008,63(1):39-45.
[9]Rehfeldt C,Kalbe C,Nürnberg G,et al.Dose-dependent effects of genistein and daidzein on protein metabolism in porcine myotube cultures[J].J Agric Food Chem,2009,57(3):852-857.
[10]Rehfeldt C,Adamovic I,Kuhn G.Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny[J].Meat Sci,2007,75(1):103-111.
[11]Kim E H,Kim S H,Chung J I,et al.Analysis of phenolic compounds and isoflavones in soybean seeds(Glycine max(L.)Merill)and sprouts grown under different conditions[J].Eur Food Res Technol,2006,222(1-2):201.
[12]张逊,姚文,朱伟云.肠道大豆异黄酮降解菌研究进展[J].世界华人消化杂志,2006,14(10):973-978.
[13]Otieno D O,Ashton J F,Shah N E.Stability ofβ-glucosidase activity produced by Bifidobacterium and Lactobacillus spp.in fermented soymilk during processing and storage[J].J Food Sci,2005,70(4):M236-M241.
[14]Hsieh M C,Graham T L.Partial purification and characterization of a soybeanβ-glucosidase with high specific activity towards isoflavone conjugates[J].Phytochemistry,2001,58(7):995-1005.
[15]Tsuchihashi R,Sakamoto S,Kodera M,et al.Microbial metabolism of soy isoflavones by human intestinal bacterial strains[J].J Nat Med,2008,62(4):456-460.
[16]韩婷,程钢,刘莹,等.β-葡萄糖苷酶以及益生菌生物转化大豆异黄酮糖苷的研究进展[J].食品科学,2010(9):333-337.
[17]王云,曾沃坦.黑曲霉Aspergillus niger S菌株所产β-葡糖苷酶的纯化和酶学性质[J].中国科学院研究生院学报,2009,26(2):274-279.
[18]Choi Y B,Kim K S,Rhee J S.Hydrolysis of soybean isoflavone glucosides by lactic acid bacteria[J].Biotechnol Lett,2002,24(24):2113-2116.
[19]Tsangalis D,Ashton J F,McGill A E J,et al.Enzymic transformation of isoflavone phytoestrogens in soymilk by β glucosidase producing bifidobacteria[J].J Food Sci,2002,67(8):3104-3113.
[20]Cederroth S C,Stitt T N,Gonzalez M,et al.Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism[J].Diabetes,2008,57(5):1176-1185.
[21]Jang E H,Ko J H,Ahn C W,et al.In vivo and in vitro application of black soybean peptides in the amelioration of endoplasmic reticulum stress and improvement of insulin resistance[J].Life Sci,2010,86(7-8):267-274.
[22]Heinonen S,W?h?l?K,Adlercreutz H.Identification of isoflavone metabolites dihydrodaidzein,dihydrogenistein,6'-OH-O-dma,and cis-4-OH-equol in human urine by gas chromatography-mass spectroscopy using authentic reference compounds[J].Anal Biochem,1999,274(2):211-219.
[23]Rowland I R,Wiseman H,Sanders T A B,et al.Interindividual variation in metabolism of soy isoflavones and lignans:influence of habitual diet on equol production by the gut microflora[J].Nutr Cancer,2000,36(1):27-32.
[24]Cheong S H,Furuhashi K,Ito K,et al.Antihyperglycemic effect of equol,a daidzein derivative,in cultured L6 myocytes and ob/ob mice[J].Mol Nutr Food Res,2014,58(2):267-277.
[25]Rasbach K A,Schnellmann R G.Isoflavones promote mitochondrial biogenesis[J].J Pharmaco Exp Ther,2008,325(2):536-543.
[26]Yoshino M,Naka A,Sakamoto Y,et al.Dietary isoflavone daidzein promotes Tfam expression that increases mitochondrial biogenesis in C2C12 muscle cells[J].J Nutr Biochem,2015,26(11):1193-1199.
[27]Rehfeldt C,Kalbe C,Nürnberg G,et al.Dose-dependent effects of genistein and daidzein on protein metabolism in porcine myotube cultures[J].J Agric Food Chem,2009,57(3):852-857.
[28]Hirasaka K,Maeda T,Ikeda C,et al.Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12myotubes through SIRT1 activation[J].J Nutr Sci Vitaminol,2013,59(4):317-324.
[29]Bodine S C,Stitt T N,Gonzalez M,et al.Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo[J].Nat Cell Biol,2001,3(11):1014.
[30]Ogawa M,Kitano T,Kawata N,et al.Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptorβand increases skeletal muscle mass in young female mice[J].J Nutr Biochem,2017,49:63-70.
[31]Zhang Y,Yu B,He J,et al.From nutrient to microRNA:a novel insight into cell signaling involved in skeletal muscle development and disease[J].Int J Biol Sci,2016,12(10):1247-1261.
[32]Velders M,Schleipen B,Fritzemeier K H,et al.Selective estrogen receptor-βactivation stimulates skeletal muscle growth and regeneration[J].FASEB J,2012,26(5):1909-1920.
[33]Akiyama T,Ishida J,Nakagawa S,et al.Genistein,a specific inhibitor of tyrosine-specific protein kinases[J].J Biol Chem1987,262(12):5592-5595.
[34]Salti G I,Grewal S,Mehta R R,et al.Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells[J].Eur J Cancer,2000,36(6):796-802.
[35]Gan M,Yang D,Fan Y,et al.Bidirectional regulation of genistein on the proliferation and differentiation of C2C12 myoblasts[J]Xenobiotica,2017,24:1-15.
[36]Koganti P P,Wang J,Cleveland B,et al.Estradiol regulates expression of miRNAs associated with myogenesis in rainbow trout[J].Mol Cell Endocrinol,2017,443:1-14.
[37]Rehfeldt C,Adamovic I,Kuhn G.Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny[J].Meat Sci,2007,75(1):103-111.
[38]Zheng W,Hemker M L,Xie M,et al.Anabolic activity of a soy extract and three major isoflavones in c2c12 myotubes[J].Planta Med,2018,84(14):1022-1029.
[39]Velders M,Solzbacher M,Schleipen B,et al.Estradiol and genistein antagonize the ovariectomy effects on skeletal muscle myosin heavy chain expression via ER-βmediated pathways[J].J Steroid Biochem Mol Biol,2010,120(1):53-59.
[40]Guo T,Liu W,Konermann A,et al.Estradiol modulates the expression pattern of myosin heavy chain subtypes via an ERα-Mediated pathway in muscle-derived tissues and satellite cells[J].Cell Physiol Biochem,2014,33(3):681-691.
[41]Kamboh A A,Zhu W Y.Individual and combined effects of genistein and hesperidin supplementation on meat quality in meat type broiler chickens[J].J Sci Food Agric,2013,93(13):3362-3367.
[42]Jiang Z Y,Jiang S Q,Lin Y C,et al.Effects of soybean isoflavone on growth performance,meat quality,and antioxidation in male broilers[J].Poult Sci,2007,86(7):1356-1362.
[43]倪迎冬,洪文杰,任灵芝,等.大豆黄酮对母鸡蛋品质及后代仔鸡肉品质的影响[J].畜牧兽医学报,2007,38(11):1188-1194.
[44]Payne R L,Bidner T D,Southern L L,et al.Effects of dietary soy isoflavones on growth,carcass traits,and meat quality in growing-finishing pigs[J].J Anim Sci,2001,79(5):1230-1239.
[45]Chen W,Ma X,Lin Y,et al.Dietary supplementation with a high dose of daidzein enhances the antioxidant capacity in swine muscle but experts pro-oxidant function in liver and fat tissues[J].J Anim Sci Biotechnol,2016,7(1):43.
[46]Wei X J,Ni Y D,Lu L Z,et al.The effect of equol injection in ovo on posthatch growth,meat quality and antioxidation in broilers[J].Animal,2011,5(2):320-327.
[47]Yang H,Li F,Xiong X,et al.Soy isoflavones modulate adipokines and myokines to regulate lipid metabolism in adipose tissue,skeletal muscle and liver of male Huanjiang minipigs[J].Mol Cell Endocrinol,2013,365(1):44-51.
[48]Ohtomo T,Uehara M,Pe?alvo J L,et al.Comparative activities of daidzein metabolites,equol and O-desmethylangolensin,on bone mineral density and lipid metabolism in ovariectomized mice and in osteoclast cell cultures[J].Eur J Nutr,2008,47(5):273-279.
[49]Zhao X H,Yang Z Q,Bao L B,et al.Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers[J].Exp Biol Med,2015,240(9):1152-1157.
[50]Cho K W,Lee O H,Banz W J,et al.Daidzein and the daidzein metabolite,equol,enhance adipocyte differentiation and PPARγtranscriptional activity[J].J Nutr Biochem,2010,21(9):841-847.
[2]Zhang Q,Xie H,Chen D,et al.Dietary daidzein supplementation during pregnancy facilitates fetal growth in rats[J].Mol Nutr Food Res,2018,62(24):1800921.
[3]Lee C H,Yang L,Xu J Z,et al.Relative antioxidant activity of soybean isoflavones and their glycosides[J].Food Chem,2005,90(4):736-741.
[4]Yu J,Bi X,Yu B,et al.Isoflavones:anti-inflammatory benefit and possible caveats[J].Nutrients,2016,8(6):361.
[5]Sakai T,Kogiso M.Soy isoflavones and immunity[J].J Med Invest,2008,55(3,4):167-173.
[6]Lee S J,Vuong T A,Go G Y,et al.An isoflavone compound daidzein elicits myoblast differentiation and myotube growth[J].JFunct Foods,2017,38:438-446.
[7]Cheong S H,Furuhashi K,Ito K,et al.Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice[J].J Nutr Biochem,2014,25(2):136-143.
[8]Mau M,Kalbe C,Viergutz T,et al.Effects of dietary isoflavones on proliferation and DNA integrity of myoblasts derived from newborn piglets[J].Pediatr Res,2008,63(1):39-45.
[9]Rehfeldt C,Kalbe C,Nürnberg G,et al.Dose-dependent effects of genistein and daidzein on protein metabolism in porcine myotube cultures[J].J Agric Food Chem,2009,57(3):852-857.
[10]Rehfeldt C,Adamovic I,Kuhn G.Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny[J].Meat Sci,2007,75(1):103-111.
[11]Kim E H,Kim S H,Chung J I,et al.Analysis of phenolic compounds and isoflavones in soybean seeds(Glycine max(L.)Merill)and sprouts grown under different conditions[J].Eur Food Res Technol,2006,222(1-2):201.
[12]张逊,姚文,朱伟云.肠道大豆异黄酮降解菌研究进展[J].世界华人消化杂志,2006,14(10):973-978.
[13]Otieno D O,Ashton J F,Shah N E.Stability ofβ-glucosidase activity produced by Bifidobacterium and Lactobacillus spp.in fermented soymilk during processing and storage[J].J Food Sci,2005,70(4):M236-M241.
[14]Hsieh M C,Graham T L.Partial purification and characterization of a soybeanβ-glucosidase with high specific activity towards isoflavone conjugates[J].Phytochemistry,2001,58(7):995-1005.
[15]Tsuchihashi R,Sakamoto S,Kodera M,et al.Microbial metabolism of soy isoflavones by human intestinal bacterial strains[J].J Nat Med,2008,62(4):456-460.
[16]韩婷,程钢,刘莹,等.β-葡萄糖苷酶以及益生菌生物转化大豆异黄酮糖苷的研究进展[J].食品科学,2010(9):333-337.
[17]王云,曾沃坦.黑曲霉Aspergillus niger S菌株所产β-葡糖苷酶的纯化和酶学性质[J].中国科学院研究生院学报,2009,26(2):274-279.
[18]Choi Y B,Kim K S,Rhee J S.Hydrolysis of soybean isoflavone glucosides by lactic acid bacteria[J].Biotechnol Lett,2002,24(24):2113-2116.
[19]Tsangalis D,Ashton J F,McGill A E J,et al.Enzymic transformation of isoflavone phytoestrogens in soymilk by β glucosidase producing bifidobacteria[J].J Food Sci,2002,67(8):3104-3113.
[20]Cederroth S C,Stitt T N,Gonzalez M,et al.Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism[J].Diabetes,2008,57(5):1176-1185.
[21]Jang E H,Ko J H,Ahn C W,et al.In vivo and in vitro application of black soybean peptides in the amelioration of endoplasmic reticulum stress and improvement of insulin resistance[J].Life Sci,2010,86(7-8):267-274.
[22]Heinonen S,W?h?l?K,Adlercreutz H.Identification of isoflavone metabolites dihydrodaidzein,dihydrogenistein,6'-OH-O-dma,and cis-4-OH-equol in human urine by gas chromatography-mass spectroscopy using authentic reference compounds[J].Anal Biochem,1999,274(2):211-219.
[23]Rowland I R,Wiseman H,Sanders T A B,et al.Interindividual variation in metabolism of soy isoflavones and lignans:influence of habitual diet on equol production by the gut microflora[J].Nutr Cancer,2000,36(1):27-32.
[24]Cheong S H,Furuhashi K,Ito K,et al.Antihyperglycemic effect of equol,a daidzein derivative,in cultured L6 myocytes and ob/ob mice[J].Mol Nutr Food Res,2014,58(2):267-277.
[25]Rasbach K A,Schnellmann R G.Isoflavones promote mitochondrial biogenesis[J].J Pharmaco Exp Ther,2008,325(2):536-543.
[26]Yoshino M,Naka A,Sakamoto Y,et al.Dietary isoflavone daidzein promotes Tfam expression that increases mitochondrial biogenesis in C2C12 muscle cells[J].J Nutr Biochem,2015,26(11):1193-1199.
[27]Rehfeldt C,Kalbe C,Nürnberg G,et al.Dose-dependent effects of genistein and daidzein on protein metabolism in porcine myotube cultures[J].J Agric Food Chem,2009,57(3):852-857.
[28]Hirasaka K,Maeda T,Ikeda C,et al.Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12myotubes through SIRT1 activation[J].J Nutr Sci Vitaminol,2013,59(4):317-324.
[29]Bodine S C,Stitt T N,Gonzalez M,et al.Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo[J].Nat Cell Biol,2001,3(11):1014.
[30]Ogawa M,Kitano T,Kawata N,et al.Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptorβand increases skeletal muscle mass in young female mice[J].J Nutr Biochem,2017,49:63-70.
[31]Zhang Y,Yu B,He J,et al.From nutrient to microRNA:a novel insight into cell signaling involved in skeletal muscle development and disease[J].Int J Biol Sci,2016,12(10):1247-1261.
[32]Velders M,Schleipen B,Fritzemeier K H,et al.Selective estrogen receptor-βactivation stimulates skeletal muscle growth and regeneration[J].FASEB J,2012,26(5):1909-1920.
[33]Akiyama T,Ishida J,Nakagawa S,et al.Genistein,a specific inhibitor of tyrosine-specific protein kinases[J].J Biol Chem1987,262(12):5592-5595.
[34]Salti G I,Grewal S,Mehta R R,et al.Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells[J].Eur J Cancer,2000,36(6):796-802.
[35]Gan M,Yang D,Fan Y,et al.Bidirectional regulation of genistein on the proliferation and differentiation of C2C12 myoblasts[J]Xenobiotica,2017,24:1-15.
[36]Koganti P P,Wang J,Cleveland B,et al.Estradiol regulates expression of miRNAs associated with myogenesis in rainbow trout[J].Mol Cell Endocrinol,2017,443:1-14.
[37]Rehfeldt C,Adamovic I,Kuhn G.Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny[J].Meat Sci,2007,75(1):103-111.
[38]Zheng W,Hemker M L,Xie M,et al.Anabolic activity of a soy extract and three major isoflavones in c2c12 myotubes[J].Planta Med,2018,84(14):1022-1029.
[39]Velders M,Solzbacher M,Schleipen B,et al.Estradiol and genistein antagonize the ovariectomy effects on skeletal muscle myosin heavy chain expression via ER-βmediated pathways[J].J Steroid Biochem Mol Biol,2010,120(1):53-59.
[40]Guo T,Liu W,Konermann A,et al.Estradiol modulates the expression pattern of myosin heavy chain subtypes via an ERα-Mediated pathway in muscle-derived tissues and satellite cells[J].Cell Physiol Biochem,2014,33(3):681-691.
[41]Kamboh A A,Zhu W Y.Individual and combined effects of genistein and hesperidin supplementation on meat quality in meat type broiler chickens[J].J Sci Food Agric,2013,93(13):3362-3367.
[42]Jiang Z Y,Jiang S Q,Lin Y C,et al.Effects of soybean isoflavone on growth performance,meat quality,and antioxidation in male broilers[J].Poult Sci,2007,86(7):1356-1362.
[43]倪迎冬,洪文杰,任灵芝,等.大豆黄酮对母鸡蛋品质及后代仔鸡肉品质的影响[J].畜牧兽医学报,2007,38(11):1188-1194.
[44]Payne R L,Bidner T D,Southern L L,et al.Effects of dietary soy isoflavones on growth,carcass traits,and meat quality in growing-finishing pigs[J].J Anim Sci,2001,79(5):1230-1239.
[45]Chen W,Ma X,Lin Y,et al.Dietary supplementation with a high dose of daidzein enhances the antioxidant capacity in swine muscle but experts pro-oxidant function in liver and fat tissues[J].J Anim Sci Biotechnol,2016,7(1):43.
[46]Wei X J,Ni Y D,Lu L Z,et al.The effect of equol injection in ovo on posthatch growth,meat quality and antioxidation in broilers[J].Animal,2011,5(2):320-327.
[47]Yang H,Li F,Xiong X,et al.Soy isoflavones modulate adipokines and myokines to regulate lipid metabolism in adipose tissue,skeletal muscle and liver of male Huanjiang minipigs[J].Mol Cell Endocrinol,2013,365(1):44-51.
[48]Ohtomo T,Uehara M,Pe?alvo J L,et al.Comparative activities of daidzein metabolites,equol and O-desmethylangolensin,on bone mineral density and lipid metabolism in ovariectomized mice and in osteoclast cell cultures[J].Eur J Nutr,2008,47(5):273-279.
[49]Zhao X H,Yang Z Q,Bao L B,et al.Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers[J].Exp Biol Med,2015,240(9):1152-1157.
[50]Cho K W,Lee O H,Banz W J,et al.Daidzein and the daidzein metabolite,equol,enhance adipocyte differentiation and PPARγtranscriptional activity[J].J Nutr Biochem,2010,21(9):841-847.