分子印迹复合膜在拆分延胡索乙素对映体中的应用
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摘要
目的研究分子印迹复合膜在拆分延胡索乙素对映体中的应用。方法以偏聚乙烯微孔滤膜为载体,左旋延胡索乙素为模板分子,甲基丙烯酸为功能单体,乙二醇二甲基丙烯酸酯为交联剂,制备分子印迹复合膜,并进行渗透试验。再应用自制左旋延胡索乙素分子印迹整体柱考察其拆分性能。结果左旋延胡索乙素、致孔剂(氯仿)、甲基丙烯酸、乙二醇二甲基丙烯酸酯的最佳比例为1∶10∶5∶20,所得分子印迹复合膜中左旋延胡索乙素的渗透率高于右旋延胡索乙素。结论分子印迹复合膜对延胡索乙素具有一定拆分能力。
引文
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[13]王捷,刘宗河,焦爱军,等.紫外分光光度法测定复方金蒲片中延胡索乙素含量[J].广西医学,2004,26(12):1770-1772.
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[2]朱俊访,李博.左旋延胡索乙素印迹聚合物的制备及固相萃取应用[J].中草药,2016,47(1):72-75.
[3]Zhang Y,Shan X,Gao X.Development of a molecularly imprinted membrane for selective separation of flavonoids[J].Sep Purif Technol,2011,76(3):337-344.
[4]Ma X,Chen R,Zheng X,et al.Preparation of molecularly imprinted CS membrane for recognizing naringin in aqueous media[J].Polym Bull,2011,66(6):853-863.
[5]Kryvshenko G A,Apel P,Abramchuk S S,et al.A highly permeable membrane for separation of quercetin obtained by Nickel(II)ion-mediated molecular imprinting[J].Sep Sci Technol,2012,47(12):1715-1724.
[6]Yue K,Ma B,Ru Q,et al.The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats[J].Pharmacol Biochem Behav,2012,102(1):1-5.
[7]洪战英,范国荣,柴逸峰,等.延胡索乙素在大鼠体内的立体选择性药代动力学[J].药学学报,2005,40(8):746-749.
[8]洪战英,范国荣,柴逸峰,等.延胡索乙素的大鼠在体肠道吸收与立体选择性特征研究[J].中国药学杂志,2007,42(14):1104-1107.
[9]吴佩盛,黄善定,叶亚菊,等.大鼠肠道对左旋延胡索乙素及其消旋体的吸收差异研究[J].药学学报,2007,42(5):534-537.
[10]赵鸣,李丽萍,沈剑,等.延胡索乙素对映体对小鼠CYP450酶诱导和抑制作用研究[J].浙江大学学报:医学版,2011,40(1):33-39.
[11]颜晶晶,俸珊,何丽娜,等.延胡索乙素对映体对人体肝微粒体细胞P450酶抑制作用机制研究[J].中草药,2015,46(4):534-540.
[12]国家药典委员会.中华人民共和国药典:2015年版一部[S].北京:中国医药科技出版社,2015:139.
[13]王捷,刘宗河,焦爱军,等.紫外分光光度法测定复方金蒲片中延胡索乙素含量[J].广西医学,2004,26(12):1770-1772.
[14]Ou J,Kong L,Pan C,et al.Determination of DL-tetrahydropalmatine in Corydalis yanhusuo by L-tetrahydropalmatine imprinted monolithic column coupling with reversed-phase high performance liquid chromatography[J].J Chromatogr A,2006,1117(2):163-169.