流感病毒生命周期研究进展
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摘要
流感病毒引起急性呼吸道感染,分为季节性流感和大流行流感。季节性流感每年都有发生,感染后可以导致肺炎和急性呼吸道衰竭,往往并发细菌共感染。大流行流感每隔一段时间发生一次,具有高致病性特点。近年来大流行流感频繁暴发,带来了巨大的经济和社会负担。本文从流感病毒生物学、生命周期等方面进行简要综述,有助于为预防和治疗流感病毒感染提供策略。
Influenza viruses cause acute respiratory infections, including seasonal epidemics and periodically pandemics. The seasonal influenza that occurs yearly lead to severe pneumonia and acute respiratory distress syndrome, often accompanied by bacterial co-infection. Pandemic influenza occurs at regular intervals and is highly pathogenic. In recent years, the frequent outbreak of pandemic influenza has brought huge economic losses and social burden. In this paper we reviewed the biology and life cycle of influenza virus, which contributes to making strategies for the prevention and treatment of influenza virus infection.
Influenza viruses cause acute respiratory infections, including seasonal epidemics and periodically pandemics. The seasonal influenza that occurs yearly lead to severe pneumonia and acute respiratory distress syndrome, often accompanied by bacterial co-infection. Pandemic influenza occurs at regular intervals and is highly pathogenic. In recent years, the frequent outbreak of pandemic influenza has brought huge economic losses and social burden. In this paper we reviewed the biology and life cycle of influenza virus, which contributes to making strategies for the prevention and treatment of influenza virus infection.
引文
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[2]Lee V J,Ho Z J M,Goh E H,et al.Advances in measuring influenza burden of disease[J].Influenza Other Resp,2018,12(1):3-9.
[3]Fan V Y,Jamison D T,Summers L H.Pandemic risk:how large are the expected losses[J]?Bull World Health Organ,2018,96(2):129-134.
[4]李康.抗流感病毒和EV71新靶标及新药物研究[D].北京:北京工业大学,2014.
[5]Wang X Y,Chai C L,Li F D,et al.Epidemiology of human infections with avian influenza A(H7N9)virus in the two waves before and after October 2013 in Zhejiang province,China[J].Epidemiol Infect,2015,143(9):1839-1845.
[6]Sullivan,S.Challenges in reducing influenza-associated mortality[J].Lancet,2018,391(10127):1242-1244.
[7]Fujiyoshi Y,Kume N P,Sakata K,et al.Fine structure of influenza A virus observed by electron cryomicroscopy[J].EMBO J,1994,13(2):318-326.
[8]Voskarides K,Christaki E,Nikolopoulos G K.Influenza virus-host co-evolution.A predator-prey relationship[J]?Front Immunol,2018,9:2017.
[9]Ma W,Garcia-Sastre A,Schwemmle M.Expected and unexpected features of the newly discovered bat influenza A-like viruses[J].PLoS Pathog,2015,11(6):e1004819.
[10]Watanabe T,Watanabe S,Kawaoka Y.Cellular networks involved in the influenza virus life cycle[J].Cell Host Microbe,2010,7(6):427-439.
[11]Zhang J,Pekosz A,Lamb R A.Influenza virus assembly and lipid raft microdomains:a role for the cytoplasmic tails of the spike glycoproteins[J].J Virol,2000,74(10):4634-4644.
[12]Kapoor S,Dhama K.Replication cycle of influenza viruses[M].Springer International Publishing,2014:15-30.
[13]Sun X,Whittaker G R.Entry of influenza virus[J].Adv Exp Med Biol,2013,790:72.
[14]Lakadamyali M,Rust M J,Zhuang X.Endocytosis of influenza viruses[J].Microbes Infect,2004,6(10):929-936.
[15]Rust M J,Lakadamyali M,Zhang F,et al.Assembly of endocytic machinery around individual influenza viruses during viral entry[J].Nat Struct Mol Biol,2004,11(6):567-573.
[16]Yoshimura A,Ohnishi S.Uncoating of influenza virus in endosomes[J].J Virol,1984,51(2):497-504.
[17]Gorvel J P,Chavrier P,Zerial M,et al.rab5 controls early endosome fusion in vitro[J].Cell,1991,64(5):915-925.
[18]Suzanne P.Membrane domains in the secretory and endocytic pathways[J].Cell,2003,112(4):507-517.
[19]Cross K,Langley W,Russell R,et al.Composition and functions of the influenza fusion peptide[J].Protein Peptide Lett,2009,16(7):766-778.
[20]Danieli T,Pelletier S L,Henis Y I,et al.Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers[J].J Cell Biol,1996,133(3):559-569.
[21]Sun X,Whittaker G R.Role for influenza virus envelope cholesterol in virus entry and infection[J].J Virol,2003,77(23):12543-12551.
[22]Pinto L H,Lamb R A.The M2 proton channels of influenza A and B viruses[J].J Biol Chem,2006,281(14):8997-9000.
[23]Eisfeld A J,Neumann G,Kawaoka Y.At the centre:influenza A virus ribonucleoproteins[J].Nat Rev Microbiol,2014,13(1):28-41.
[24]Qin C,Li W,Li Q,et al.Real-time dissection of dynamic uncoating of individual influenza viruses[J].Proc Natl Acad Sci USA,2019,116(7):2577-2582.
[25]Brownlee G G,Sharps J L.The RNA polymerase of influenza A virus is stabilized by interaction with its viral RNA promoter[J].J Virol,2002,76(14):7103-7113.
[26]Dias A,Bouvier D,Crepin T,et al.The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit[J].Nature,2009,458(7240):914-918.
[27]Guilligay D,Tarendeau F,Resa-Infante P,et al.The structural basis for cap binding by influenza virus polymerase subunit PB2[J].Nat Struct Mol Biol,2008,15(5):500-506.
[28]Liao T L,Wu C Y,Su W C,et al.Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication[J].EMBO J,2010,29(22):3879-3890.
[29]Wasilenko J L,Sarmento L,Pantin-Jackwood M J.Asingle substitution in amino acid 184 of the NP protein alters the replication and pathogenicity of H5N1avian influenza viruses in chickens[J].Arch Virol,2009,154(6):969-979.
[30]Nayak D P,Hui E K,Barman S.Assembly and budding of influenza virus[J].Virus Res,2004,106(2):147-165.
[31]Elton D,Simpson-Holley M,Archer K,et al.Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway[J].J Virol,2001,75(1):408-419.
[32]Akarsu H.Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein(NEP/NS2)[J].EMBO J,2003,22(18):4646-4655.
[33]Scheiffele P,Rietveld A,Wilk T,et al.Influenza viruses select ordered lipid domains during budding from the plasma membrane[J].J Biol Chem,1999,274(4):2038-2044.