清肺平喘汤对呼吸道合胞病毒肺炎患儿Eotaxin及IL-17的影响
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摘要
目的研究清肺平喘汤对痰热闭肺型呼吸道合胞病毒肺炎婴幼儿治疗前后血清中和痰液中嗜酸粒细胞趋化因子(Eotaxin)、白介素17(IL-17)的影响及意义。方法将160例呼吸道合胞病毒肺炎(中医辨证为痰热闭肺型肺炎喘嗽)患儿随机分成自制清肺平喘汤治疗治疗组68例及常规治疗对照组66例,分别检测两组在治疗前后呼吸道合胞病毒肺炎患儿血清中和痰液Eotaxin、IL-17的变化,并进行统计分析。结果与对照组比较,治疗组治疗前后Eotaxin、IL-17明显降低(P <0. 01)。结论研究表明Eotaxin和IL-17在呼吸道合胞病毒肺炎病变中表达明显增高,清肺平喘汤可通过降低患儿体内Eotaxin和IL-17水平,减少炎症细胞在肺组织局部浸润,抑制气道炎症。清肺平喘汤可以有效降低呼吸道合胞病毒肺炎患儿全身炎症反应及炎症相关因子产生,逆转患儿气道重塑过程,具有积极的临床意义。
Objective: To study the effect and significance of Clearing Lung-Heat and Relieve Panting Decoction on eosinophil chemokines( Eotaxin) and interleukin 17( IL-17) in serum and sputum of infants with respiratory syncytial virus pneumonia due to phlegm-heat lung blocking before and after treatment. Method: 160 children with respiratory syncytial virus pneumonia( TCM syndrome differentiation as phlegm-heat lung blocking type of pneumonia with dyspnea and cough) were randomly divided into self-made Clearing Lung-Heat and Relieve Panting Decoction treatment group( 68 cases) and conventional treatment control group( 66 cases). The changes of Eotaxin and IL-17 in serum and sputum of children with respiratory syncytial virus pneumonia before and after treatment in both groups were detected and analyzed. Result: Compared with the control group,Eotaxin and IL-17 in the treatment group decreased significantly before and after treatment( P < 0. 01). Conclusion: Studies have shown that the expression of Eotaxin and IL-17 in respiratory syncytial virus pneumonia is significantly increased. Clearing Lung-Heat and Relieve Panting Decoction can reduce the level of Eotaxin and IL-17 in children and the local infiltration of inflammatory cells in lung tissue to inhibit airway inflammation. It can also effectively reduce systemic inflammatory response and production of inflammatory related factors in children with respiratory syncytial virus pneumonia,and reverse the process of airway remodeling,with positive clinical significance.
Objective: To study the effect and significance of Clearing Lung-Heat and Relieve Panting Decoction on eosinophil chemokines( Eotaxin) and interleukin 17( IL-17) in serum and sputum of infants with respiratory syncytial virus pneumonia due to phlegm-heat lung blocking before and after treatment. Method: 160 children with respiratory syncytial virus pneumonia( TCM syndrome differentiation as phlegm-heat lung blocking type of pneumonia with dyspnea and cough) were randomly divided into self-made Clearing Lung-Heat and Relieve Panting Decoction treatment group( 68 cases) and conventional treatment control group( 66 cases). The changes of Eotaxin and IL-17 in serum and sputum of children with respiratory syncytial virus pneumonia before and after treatment in both groups were detected and analyzed. Result: Compared with the control group,Eotaxin and IL-17 in the treatment group decreased significantly before and after treatment( P < 0. 01). Conclusion: Studies have shown that the expression of Eotaxin and IL-17 in respiratory syncytial virus pneumonia is significantly increased. Clearing Lung-Heat and Relieve Panting Decoction can reduce the level of Eotaxin and IL-17 in children and the local infiltration of inflammatory cells in lung tissue to inhibit airway inflammation. It can also effectively reduce systemic inflammatory response and production of inflammatory related factors in children with respiratory syncytial virus pneumonia,and reverse the process of airway remodeling,with positive clinical significance.
引文
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[2]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:78-79.
[3]易阳,钟闻燕,熊建新,等.嗜酸性粒细胞趋化因子在呼吸道合胞病毒性毛细支气管炎中的作用和意义[J].临床儿科杂志,2011,29(2):136-138.
[4]Tanaka S,Yoshimoto T,Naka T,etal.Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses[J].J Immunol,2009,183(11):7523-7530.
[5]Besnard AG,Togbe D,Guillou N,etal.IL-33-activated dendritic cells are critical for allergic airway inflammation[J].Eur J Immunol,2011,41(6):1675-1686.
[6]洪岩,陈垣,欧静琳,等,中药清肺平喘汤对呼吸道合胞病毒肺炎患儿临床及诱导痰细胞学的影响[J].陕西中医,2012,33(11):1140-1141.
[7]李堆淑.中药黄芩化学成分的研究进展[J].江西农业学报2013,25(8):51-54.
[8]黄楦槟,陈金水.苏子油的药理作用研究进展[J].光明中医,2015,30(9):2039-2041.
[9]冯志毅,杨梦,白义萍,等.桑白皮化学拆分组分免疫调节作用研究[J].世界科学技术-中医药现代化,2014,16(9):1968-1973.
[10]马艳芳,刘云昊.中西医结合治疗小儿肺炎喘嗽风热闭肺证49例[J].陕西中医药大学学报,2017,40(4):56-58.
[11]李海涛,张伟.张伟教授运用苏子降气汤治疗老年慢性喘息性支气管炎经验[J].陕西中医药大学学报,2017,40(5):24-26.
[12]高晔珩,党力纳.麻黄研究进展[J].陕西中医学院学报,2003,26(6):60-61.