雾化吸入不同植物精油对小鼠的抗晕动病作用
|
摘要
目的观察雾化吸入生姜精油、橘皮精油及食醋对小鼠晕动症的预防作用。方法预先分别使小鼠雾化吸入(0. 1 ml/只) 15 min生姜精油、橘皮精油、食醋雾化吸入后制备晕动症模型,立即观察小鼠的晕动症症状、旷地行为实验和爬绳实验,评价上述3种物质对晕动症小鼠的预防作用。结果旷地行为实验发现,雾化吸入生姜精油的小鼠四肢恢复时间、尾巴离地时间明显短于对照组(P<0. 05),雾化吸入橘皮精油有助于小鼠的四肢运动恢复且可明显增加小鼠抓脸次数(P<0. 05),雾化吸入食醋可缩短小鼠四肢恢复时间和腹部离地时间(P<0. 05);雾化吸入生姜精油、橘皮精油、食醋能显著降低小鼠晕动症状评分(P<0. 05);与对照组相比,生姜精油组、食醋组小鼠爬绳所用时间明显减少(P<0. 05),橘皮精油组未见明显差异(P>0. 05)。结论雾化吸入生姜精油、橘皮精油、食醋对小鼠晕动症有不同程度的抗晕动病作用。
引文
[1]Bowins B. Motion sickness:a negative reinforcement model[J]. Brain Res Bull,2010,81(1):7-11.
[2] Lucertini M,Lugli V,Casagrande M,et al. Effects of airsickness in male and female student pilots:adaptation rates and 4-year outcomes[J]. Aviat Space Environ Med,2008,79(7):677-684.
[3]Herron DG. The ups and downs of motion sickness[J]. Am J Nurs,2010,110(12):49-51.
[4]Money KE. Motion sickness[J]. Physiol Rev,1970,50(1):1-39.
[5] Rine RM,Schubert MC,Balkany TJ. Visual-vestibular habituation and balance training for motion sickness[J]. Phys Ther,1999,79(10):949-957.
[6]Sherman CR. Motion sickness:review of causes and preventive strategies[J]. J Travel Med,2002,9(5):251-256.
[7] Lackner JR,Dizio P. Space motion sickness[J]. Exp Brain Res,2006,175(3):377-399.
[8]Paule MG,Chelonis JJ,Blake DJ,et al. Effects of drug countermeasures for space motion sickness on working memory in humans[J]. Neurotoxicol Teratol,2004,26(6):825-837.
[9]余巧玲,宋珂珂,王宇,等.不同气味因素对幼年小鼠晕动病的影响[J].中国儿童保健杂志,2012,20(1):38-48.
[10]魏昕.晕动病评价指标的验证和应用[D].上海:第二军医大学,2011.
[11]郭琪,赵晓红,雷虹,等.干姜及其提取物的抗晕动病作用研究[J].实用药物与临床,2015,18(3):268-271.
[12]Yu XH,Cai GJ,Liu AJ,et al. A novel animal model for motion sickness and its first application in rodents[J]. Physiol Behav,2007,92(4):702-707.
[13]van Wass M,Soffie M. Differential environmental modulation on locomotor activity,exploration and spatial behaviour in young and old rats[J]. Physiol Behav,1996,59(2):265-271.
[14]Eskin A,Riccio DC. The effects of vestibular stimulation on spontaneous activity in the rat[J]. Psychol Rec,1966,16(4):523-527.
[15]赵德雪.生姜的抗呕吐作用研究[D].青岛:青岛大学,2007.
[16]蒋苏贞,陈玉珊.干姜醇提取物对肠道平滑肌运动的影响[J].医药导报,2011,30(1):11-14.
[17]骆杨丽,曲玮,梁敬钰.柑橘属植物化学成分和药理作用研究进展[J].海峡药学,2013,25(1):1-6.
[2] Lucertini M,Lugli V,Casagrande M,et al. Effects of airsickness in male and female student pilots:adaptation rates and 4-year outcomes[J]. Aviat Space Environ Med,2008,79(7):677-684.
[3]Herron DG. The ups and downs of motion sickness[J]. Am J Nurs,2010,110(12):49-51.
[4]Money KE. Motion sickness[J]. Physiol Rev,1970,50(1):1-39.
[5] Rine RM,Schubert MC,Balkany TJ. Visual-vestibular habituation and balance training for motion sickness[J]. Phys Ther,1999,79(10):949-957.
[6]Sherman CR. Motion sickness:review of causes and preventive strategies[J]. J Travel Med,2002,9(5):251-256.
[7] Lackner JR,Dizio P. Space motion sickness[J]. Exp Brain Res,2006,175(3):377-399.
[8]Paule MG,Chelonis JJ,Blake DJ,et al. Effects of drug countermeasures for space motion sickness on working memory in humans[J]. Neurotoxicol Teratol,2004,26(6):825-837.
[9]余巧玲,宋珂珂,王宇,等.不同气味因素对幼年小鼠晕动病的影响[J].中国儿童保健杂志,2012,20(1):38-48.
[10]魏昕.晕动病评价指标的验证和应用[D].上海:第二军医大学,2011.
[11]郭琪,赵晓红,雷虹,等.干姜及其提取物的抗晕动病作用研究[J].实用药物与临床,2015,18(3):268-271.
[12]Yu XH,Cai GJ,Liu AJ,et al. A novel animal model for motion sickness and its first application in rodents[J]. Physiol Behav,2007,92(4):702-707.
[13]van Wass M,Soffie M. Differential environmental modulation on locomotor activity,exploration and spatial behaviour in young and old rats[J]. Physiol Behav,1996,59(2):265-271.
[14]Eskin A,Riccio DC. The effects of vestibular stimulation on spontaneous activity in the rat[J]. Psychol Rec,1966,16(4):523-527.
[15]赵德雪.生姜的抗呕吐作用研究[D].青岛:青岛大学,2007.
[16]蒋苏贞,陈玉珊.干姜醇提取物对肠道平滑肌运动的影响[J].医药导报,2011,30(1):11-14.
[17]骆杨丽,曲玮,梁敬钰.柑橘属植物化学成分和药理作用研究进展[J].海峡药学,2013,25(1):1-6.