石见穿及其提取物抗肿瘤的研究进展
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摘要
<正>在现今社会,肿瘤的进一步恶化是影响人体健康和生命最严重的疾病之一。近年来,恶性肿瘤在我国和全球的发病率和病死率持续上升[1-3]。我国近年的癌症数据统计分析表明,癌症患者每年都在增加[4],且治疗失败导致死亡的患者也越来越多[5]。传统的治疗方法一般是手术治疗、放射治疗和化学药物治疗,但是放疗和化疗具有很多不良反应,且肿瘤患者对化学药物会产生耐药性,是肿瘤患
引文
[1] Chen WQ,Zheng RS,Zeng HM,et al. Annual report on status of cancer in China,2011[J]. Chin J Cancer Res,2015,27(1):2-12
[2] Chen WQ,Zheng RS,Peter D,et al. Cancer Statistics in China,2015[J]. Ca Cancer J Clin,2016,66:115-132
[3] Naghavi M. The Global Burden of Cancer 2013[J]. JAMA Oncol,2015,1(4):505-527
[4] Zheng RS,Zeng HM,Zhang SW,et al. National estimates of cancer prevalence in China,2011[J]. Cancer Lett,2016,370(1):33-38
[5]陈万青,郑荣寿,张思维,等. 2012年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2016,25(1):1-8
[6] Chen ST,Lee T,Tsai T,et al. The traditional Chinese medicine Danggui Buxue Tang sensitizes colorectal cancer cells to chemoradiotherapy[J]. Molecules,2016,21(12):3-16
[7] Tang QF Sun J,Yu H,et al. The Zuo Jin Wan Formula induces mitochondrial apoptosis of cisplatin-resistant gastric cancer cells via cofilin-1[J]. Evid Based Compl Alt Med,2016(1):8203789
[8] Chen G,Qiao TT,Ding H,et al. Use of Chinese herbal medicine therapies in comprehensive hospitals in central China:A parallel survey in cancer patients and clinicians[J]. J Huazhong Univ Sci Tech Med Sci,2015,35(6):808-814
[9]匡锡菲,周晓波.周晓波主任治疗消化道疾病药对应用[J].吉林中医药,2016,36(4):347-349
[10]孙世长.加用自拟中药方治疗乙型肝炎肝硬化的临床观察[J].广西中医药,2016,39(3):26-27
[11]闫海洁,董莉,朱南孙.朱南孙教授治疗输卵管阻塞性不孕验案举隅[J].光明中医,2016,31(17):2478-2480
[12]王梅,于波,田颖,等.石见穿对大鼠子宫内膜异位症模型内分泌的影响[J].中医药学报,2006,34(2):55-57
[13]高俊峰,王秀辉,张鹏,等.石见穿化学成分和药理作用研究进展[J].中国实验方剂学杂志,2013,19(12):348-351
[14]Zhao Q,Huo X C,Sun FD,et al. Polyphenol rich extract of Salvia chinensis exhibits anticancer activity in different cancer cell lines,and induces cell cycle arrest at the G0/G1-phase,apoptosis and loss of mitochondrial membrane potential in pancreatic cancer cells[J]. Mol Med Rep,2015,12(4):4843-4850
[15]梁启超,刘爽,李荣辉,等.石见穿多糖的提取及抗肿瘤活性[J].光谱实验室,2013,30(3):1331-1334
[16]郑海音,武一曼,林信富,等.流式细胞术检测石见穿多糖诱导的肝癌细胞凋亡率[J].福建中医学院学报,2009,19(3):20-21
[17]张子涵,曹波,张钰琴,等. 10种壮药含药血清抗人肝癌细胞的实验研究[J].广西中医药,2015,38(2):41-44
[18]魏清,王燕燕,周政涛,等.石见穿总甾醇对SGC-7901细胞的影响[J].湖北中医药大学学报,2015,17(4):46-48
[19]徐敬宣,钱晓萍,林黎,等.石见穿活性部位的体外抗肿瘤作用研究[J].现代肿瘤医学,2015,23(12):1632-1637
[20]魏清,周政涛.石见穿多糖诱导肝癌细胞凋亡的实验研究[J].湖北中医药大学学报,2014,16(2):17-18
[21]钱晓萍,徐敬宣,林黎,等.中药石见穿提取物熊果酸体外抑制肿瘤细胞增殖的实验研究[J].现代肿瘤医学,2012,20(11):2244-2248
[22] Yun H,Wei HD,Miao TT,et al. Synthesis,Crystal Structure and Antitumor Activity ofa New Indolequinone Derivative of Ursolic Acid[J]. Chin J Struct Chem,2016,35(8):1167-1173
[23]Chen L,Qiu W,Tang J,et al. Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives[J]. Chin Chem Let,2011,22(4):413-416
[24]Chen GQ,Yi S,Hong D. Combined antitumor effect of ursolic acid and 5-Fluorouracil on human esophageal carcinoma cell Eca-109 in vitro[J]. Chin J Cancer Res,2010,22(1):62-67
[25]Yu YX,Lun GZ,Lin YJ,et al. Ursolic acid induces human hepatoma cell line SMMC-7721apoptosis via p53-dependent pathway[J]. Chin Med J,2010,123(14):1915-1923
[26]Ali S,Azad M. In vivo anticancer activity of vanillin semicarbazon[J]. Asian Pac J Trop med,2012:438-442
[27]Wang XH,Li LL,Wang B,et al. Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells[J]. J Huazhong U Sci Med,2009,29(6):761-764
[28]Li J,Guo WJ,Yang QY. Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15[J]. World J Ges,2002,8(3):493-495
[29]Wen J,Wei XH,Sheng XY,et al. Effect of ursolic acid on breast cancer resistance protein-mediated transport of rosuvastatin in vivo and vitro[J]. Chin Med Sci J,2015,30(4):218-225
[30]陈飞宇,李澎,甘加宽,等.桦木酸对人肝癌HepG2肿瘤干细胞增殖的影响[J].中国中医药信息杂志,2017,24(2):60-64
[31]柳芳,刘建勋,任钧国,等.石见穿提取物通过阻断血管生成抑制肿瘤生长的研究[J].中国中药杂志,2012,37(9):1285-1288
[32]权雯,钱晓萍,刘宝瑞,等.石见穿有效部位对血管内皮细胞生物学行为的影响[J].现代肿瘤医学,2013,21(8):1699-1703
[33]张善兰,钱晓萍,刘宝瑞,等.石见穿醇提取物对血管内皮细胞生物学行为的影响[J]. 2012,38(11):1257-1260
[34]朱红岩,孙玉国,曲杰,等.石见穿多糖抑制人胃癌细胞系MGC-803细胞迁移及其机制的初步研究[J].中国医药导报,2012,9(32):5-7
[35]程卓,赵文豪,吕叙鹏,等.石见穿多糖对环磷酰胺诱导小鼠免疫低下的调节作用[J].中药材,2016,39(1):183-187
[36]Shu GW,Hong ZG,Xiang MX. Antitumor immunostimulatory activity of polysaccharides from Salvia chinensis Benth[J]. J Ethnopharmacol,2015,168:237-247
[37]柳芳,刘建勋,李军梅,等.石见穿对肝癌H22荷瘤小鼠肿瘤生长的影响[J].中国实验方剂学杂志,2012,18(12):249-251
[38]程卓,赵文豪,黄旭,等.石见穿多糖对H22荷瘤小鼠的抗肿瘤免疫调节作用[J].天然产物研究与开发,2016,28(6):846-851; 915
[39]杜一江,苟金平.抗癌中药方联合西药治疗中晚期肝癌89例[J].中医研究,2014,27(12):23-25
[40]吴成亚,宋卓,李杰.芪术郁灵汤辨治食管癌经验[J].中医杂志,2016,57(21):1879-1881
[41]刘恭喜,邓来军,李有杰,等.基于中医传承辅助系统的治疗胃癌方剂组方规律分析[J].山东中医药大学学报,2016,40(1):6-10
[42]刘静.陆德铭教授运用扶正祛邪法治疗乳腺癌经验[J].中医学报,2016,31(4):470-473
[43]李堃,林安安,朱方石.益气健脾化积方对胃癌化疗增效的理论机制探讨[J].中国医药导报,2016,13(1):95-97
[44]辛晓丽,刘苓霜.刘苓霜辨治肺癌思路及验案赏析[J].亚太传统医药,2016,12(9):89-90
[45]张天博,张培彤.张培彤应用六君二母汤治疗晚期恶性淋巴瘤验案三则[J].中国中医药信息杂志,2017,24(1):110-113
[2] Chen WQ,Zheng RS,Peter D,et al. Cancer Statistics in China,2015[J]. Ca Cancer J Clin,2016,66:115-132
[3] Naghavi M. The Global Burden of Cancer 2013[J]. JAMA Oncol,2015,1(4):505-527
[4] Zheng RS,Zeng HM,Zhang SW,et al. National estimates of cancer prevalence in China,2011[J]. Cancer Lett,2016,370(1):33-38
[5]陈万青,郑荣寿,张思维,等. 2012年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2016,25(1):1-8
[6] Chen ST,Lee T,Tsai T,et al. The traditional Chinese medicine Danggui Buxue Tang sensitizes colorectal cancer cells to chemoradiotherapy[J]. Molecules,2016,21(12):3-16
[7] Tang QF Sun J,Yu H,et al. The Zuo Jin Wan Formula induces mitochondrial apoptosis of cisplatin-resistant gastric cancer cells via cofilin-1[J]. Evid Based Compl Alt Med,2016(1):8203789
[8] Chen G,Qiao TT,Ding H,et al. Use of Chinese herbal medicine therapies in comprehensive hospitals in central China:A parallel survey in cancer patients and clinicians[J]. J Huazhong Univ Sci Tech Med Sci,2015,35(6):808-814
[9]匡锡菲,周晓波.周晓波主任治疗消化道疾病药对应用[J].吉林中医药,2016,36(4):347-349
[10]孙世长.加用自拟中药方治疗乙型肝炎肝硬化的临床观察[J].广西中医药,2016,39(3):26-27
[11]闫海洁,董莉,朱南孙.朱南孙教授治疗输卵管阻塞性不孕验案举隅[J].光明中医,2016,31(17):2478-2480
[12]王梅,于波,田颖,等.石见穿对大鼠子宫内膜异位症模型内分泌的影响[J].中医药学报,2006,34(2):55-57
[13]高俊峰,王秀辉,张鹏,等.石见穿化学成分和药理作用研究进展[J].中国实验方剂学杂志,2013,19(12):348-351
[14]Zhao Q,Huo X C,Sun FD,et al. Polyphenol rich extract of Salvia chinensis exhibits anticancer activity in different cancer cell lines,and induces cell cycle arrest at the G0/G1-phase,apoptosis and loss of mitochondrial membrane potential in pancreatic cancer cells[J]. Mol Med Rep,2015,12(4):4843-4850
[15]梁启超,刘爽,李荣辉,等.石见穿多糖的提取及抗肿瘤活性[J].光谱实验室,2013,30(3):1331-1334
[16]郑海音,武一曼,林信富,等.流式细胞术检测石见穿多糖诱导的肝癌细胞凋亡率[J].福建中医学院学报,2009,19(3):20-21
[17]张子涵,曹波,张钰琴,等. 10种壮药含药血清抗人肝癌细胞的实验研究[J].广西中医药,2015,38(2):41-44
[18]魏清,王燕燕,周政涛,等.石见穿总甾醇对SGC-7901细胞的影响[J].湖北中医药大学学报,2015,17(4):46-48
[19]徐敬宣,钱晓萍,林黎,等.石见穿活性部位的体外抗肿瘤作用研究[J].现代肿瘤医学,2015,23(12):1632-1637
[20]魏清,周政涛.石见穿多糖诱导肝癌细胞凋亡的实验研究[J].湖北中医药大学学报,2014,16(2):17-18
[21]钱晓萍,徐敬宣,林黎,等.中药石见穿提取物熊果酸体外抑制肿瘤细胞增殖的实验研究[J].现代肿瘤医学,2012,20(11):2244-2248
[22] Yun H,Wei HD,Miao TT,et al. Synthesis,Crystal Structure and Antitumor Activity ofa New Indolequinone Derivative of Ursolic Acid[J]. Chin J Struct Chem,2016,35(8):1167-1173
[23]Chen L,Qiu W,Tang J,et al. Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives[J]. Chin Chem Let,2011,22(4):413-416
[24]Chen GQ,Yi S,Hong D. Combined antitumor effect of ursolic acid and 5-Fluorouracil on human esophageal carcinoma cell Eca-109 in vitro[J]. Chin J Cancer Res,2010,22(1):62-67
[25]Yu YX,Lun GZ,Lin YJ,et al. Ursolic acid induces human hepatoma cell line SMMC-7721apoptosis via p53-dependent pathway[J]. Chin Med J,2010,123(14):1915-1923
[26]Ali S,Azad M. In vivo anticancer activity of vanillin semicarbazon[J]. Asian Pac J Trop med,2012:438-442
[27]Wang XH,Li LL,Wang B,et al. Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells[J]. J Huazhong U Sci Med,2009,29(6):761-764
[28]Li J,Guo WJ,Yang QY. Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15[J]. World J Ges,2002,8(3):493-495
[29]Wen J,Wei XH,Sheng XY,et al. Effect of ursolic acid on breast cancer resistance protein-mediated transport of rosuvastatin in vivo and vitro[J]. Chin Med Sci J,2015,30(4):218-225
[30]陈飞宇,李澎,甘加宽,等.桦木酸对人肝癌HepG2肿瘤干细胞增殖的影响[J].中国中医药信息杂志,2017,24(2):60-64
[31]柳芳,刘建勋,任钧国,等.石见穿提取物通过阻断血管生成抑制肿瘤生长的研究[J].中国中药杂志,2012,37(9):1285-1288
[32]权雯,钱晓萍,刘宝瑞,等.石见穿有效部位对血管内皮细胞生物学行为的影响[J].现代肿瘤医学,2013,21(8):1699-1703
[33]张善兰,钱晓萍,刘宝瑞,等.石见穿醇提取物对血管内皮细胞生物学行为的影响[J]. 2012,38(11):1257-1260
[34]朱红岩,孙玉国,曲杰,等.石见穿多糖抑制人胃癌细胞系MGC-803细胞迁移及其机制的初步研究[J].中国医药导报,2012,9(32):5-7
[35]程卓,赵文豪,吕叙鹏,等.石见穿多糖对环磷酰胺诱导小鼠免疫低下的调节作用[J].中药材,2016,39(1):183-187
[36]Shu GW,Hong ZG,Xiang MX. Antitumor immunostimulatory activity of polysaccharides from Salvia chinensis Benth[J]. J Ethnopharmacol,2015,168:237-247
[37]柳芳,刘建勋,李军梅,等.石见穿对肝癌H22荷瘤小鼠肿瘤生长的影响[J].中国实验方剂学杂志,2012,18(12):249-251
[38]程卓,赵文豪,黄旭,等.石见穿多糖对H22荷瘤小鼠的抗肿瘤免疫调节作用[J].天然产物研究与开发,2016,28(6):846-851; 915
[39]杜一江,苟金平.抗癌中药方联合西药治疗中晚期肝癌89例[J].中医研究,2014,27(12):23-25
[40]吴成亚,宋卓,李杰.芪术郁灵汤辨治食管癌经验[J].中医杂志,2016,57(21):1879-1881
[41]刘恭喜,邓来军,李有杰,等.基于中医传承辅助系统的治疗胃癌方剂组方规律分析[J].山东中医药大学学报,2016,40(1):6-10
[42]刘静.陆德铭教授运用扶正祛邪法治疗乳腺癌经验[J].中医学报,2016,31(4):470-473
[43]李堃,林安安,朱方石.益气健脾化积方对胃癌化疗增效的理论机制探讨[J].中国医药导报,2016,13(1):95-97
[44]辛晓丽,刘苓霜.刘苓霜辨治肺癌思路及验案赏析[J].亚太传统医药,2016,12(9):89-90
[45]张天博,张培彤.张培彤应用六君二母汤治疗晚期恶性淋巴瘤验案三则[J].中国中医药信息杂志,2017,24(1):110-113