聚多巴胺包覆的金纳米棒用于大鼠下颌下腺造影成像
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摘要
用生物相容性好且毒性低的聚多巴胺对金纳米棒进行表面包覆,利用其造影增强的功能,将聚多巴胺包覆的金纳米棒应用于大鼠下颌下腺导管,实现了下颌下腺造影成像.
We demonstrate the application of polydopamine-coated gold nanorods in the CT imaging of rat submandibular gland. Biocompatible polydopamine was coated on the surface of gold nanorods to lower the toxicity. CT value rises with the increase of the concentration of polydopamine-coated gold nanorods in vitro,which indicates the high sensitivity to X-ray. The polydopamine-coated gold nanorods are further applied to rat submandibular gland in vivo and radiographs are obtained. H&E staining of heart,liver,spleen,lungand kidney show no obvious inflammation for the rats.
We demonstrate the application of polydopamine-coated gold nanorods in the CT imaging of rat submandibular gland. Biocompatible polydopamine was coated on the surface of gold nanorods to lower the toxicity. CT value rises with the increase of the concentration of polydopamine-coated gold nanorods in vitro,which indicates the high sensitivity to X-ray. The polydopamine-coated gold nanorods are further applied to rat submandibular gland in vivo and radiographs are obtained. H&E staining of heart,liver,spleen,lungand kidney show no obvious inflammation for the rats.
引文
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[2] Bankier A. A.,Macmahon H.,Goo J. M.,Rubin G. D.,Schaefer-Prokop C. M.,Naidich D. P.,Radiology,2017,285(2),584—600
[3] Wile G. E.,Leyendecker J. R.,Krehbiel K. A.,Dyer R. B.,Zagoria R. J.,Radiographics A Review Publication of the Radiological Society of North America Inc.,2016,27(2),325—340
[4] Koo H. J.,Lim S.,Choe J.,Choi S. H.,Sung H.,Do K. H.,Radiographics A Review Publication of the Radiological Society of North America Inc,2018,38(3),719—739
[5] Brenner D. J.,Mccollough C. H.,Orton C. G.,Medical Physics,2006,33(5),1189—1191
[6] Lee N.,Choi S. H.,Hyeon T.,Adv. Mater.,2013,25(19),2641—2660
[7] Yang Q.,He Q. Z.,Yu F.,Zhang Y. L.,Si Q. Y.,Medical Journal of Chinese People’s Liberation Army,2018,(2),135—139(杨琴,何其舟,余飞,张艳丽,斯光晏.解放军医学杂志,2018,(2),135—139)
[8] Dizendorf E.,Hany T. F.,Buck A.,von Schulthess G. K.,Burger C.,Journal of Nuclear Medicine,2003,44(5),732—738
[9] Jung Y.,Hwang H. S.,Na K.,Biomaterials,2018,160,15—23
[10] Kennedy R. A.,Br. J. Oral. Maxillofac. Surg.,2018,56(2),90—95
[11] Eisbruch A.,Haken R. K. T.,Kim H. M.,Marsh L. H.,Ship J. A.,Int. J. Radiat. Oncol. Biol. Phys.,1999,45(3),577—587
[12] Schulz M. D.,Weisberger R. D.,Oral. Surg. Oral. Med. Oral. Patho.,1948,1(3),233—248
[13] Thomas A. R.,Br. J. Radiol.,1956,29(340),209—312
[14] Rubin P.,Holt J. F.,Am. J. Roentgenol. Radium. Ther. Nucl. Med.,1957,77(4),575—598
[15] Zou Z. J.,Chinese Journal of Stomatology,1954,(1),18—22(邹兆菊.中华口腔科杂志,1954,(1),18—22)
[16] Zou Z. J.,Chinese Medical Journal,1978,(1),353—357(邹兆菊.中华医学杂志,1978,(1),353—357)
[17] Aframian D. J.,Keshet N.,Nadler C.,Oral. Dis.,2018,24(1/2),191—193
[18] Li W.,Wei L.,Wang F.,Peng S.,Cheng Y.,Li B.,J. Oral. Rehabil.,2018,45(12),983—989
[19] Zou Z. J.,Zhang Z. Y.,Hua H.,Chinese Journal of Stomatology,1996,(2),81—84(邹兆菊,张祖燕,华红.中华口腔医学杂志,1996,(2),81—84)
[20] Wu Y. W.,Leow K. S.,Zhu Y.,Tan C. H.,Ann. Acad. Med. Singapore,2016,45(4),157—164
[21] Bhat K. N.,Arroyave C. M.,Crown R.,Ann. Allergy,1976,37(3),169—173
[22] Cheng L.,Wang C.,Feng L.,Yang K.,Liu Z.,Chemical Reviews,2014,114(21),10869—10939
[23] He W.,Ai K.,Lu L.,Science China Chemistry,2015,58(5),753—760
[24] Yang X.,Yang M.,Pang B.,Vara M.,Xia Y.,Chemical Reviews,2015,115(19),10410—10488
[25] Li J.,Jiang F.,Yang B.,Song X. R.,Liu Y.,Yang H. H.,Cao D. R.,Shi W. R.,Chen G. N.,Scientific Reports,2013,3(6),1998—2013
[26] Lusic H.,Grinstaff M. W.,Chemical Reviews,2013,113(3),1641—1666
[27] Li B.,Ye K.,Zhang Y.,Qin J.,Zou R.,Xu K.,Huang X.,Xiao Z.,Zhang W.,Lu X.,Hu J.,Advanced Materials,2015,27(8),1339—1345
[28] Dong K.,Liu Z.,Liu J.,Huang S.,Li Z.,Yuan Q.,Ren J.,Qu X.,Nanoscale,2014,6(4),2211—2217
[29] Liu Y.,Ai K.,Lu L.,Acc. Chem. Res.,2012,45(10),1817—1827
[30] Liu S.,Wang L.,Lin M.,Wang D.,Song Z.,Li S.,Ge R.,Zhang X.,Liu Y.,Li Z.,Sun H.,Yang B.,Zhang H.,ACS Appl. Mater.Interfaces,2017,9(51),44293—44306
[31] Choi C. K. K.,Choi C. H. J.,Bian L.,J. Am. Chem. Soc.,2015,137(23),7337—7346
[32] He W.,Wu X.,Liu J.,Zhang K.,Chu W.,Feng L.,Hu X.,Zhou W.,Xie S.,J. Phys. Chem. C,2009,113(24),10505—10510