快速动眼睡眠行为障碍(RBD)与帕金森病和多系统萎缩的关系研究
摘要
研究了快速动眼睡眠行为障碍(RBD)在帕金森病和多系统萎缩患者中的出现率、出现时间和电生理特点,探讨了RBD与两种疾病之间的关系以及电生理诊断指标。帕金森病组14例,多系统萎缩组6例,性别、年龄基本匹配的正常对照组20例,所有受试者行连续两夜夜间多导睡眠监测。分析了伴发RBD的帕金森病和多系统萎缩患者的多导睡眠图特点。帕金森病和多系统萎缩合并RBD比例明显高于对照组,分别是60.3%和100%。其中帕金森病和多系统萎缩合并RBD最主要的多导睡眠图特点是下领肌弛缓消失(RWA)比例和位相性肌电活动密度增高。RBD在帕金森病和多系统萎缩患者中出现率明显增高,提示RBD与突触核蛋白病关系密切。RWA比例和位相性肌电活动密度可以作为神经变性病合并RBD的多导睡眠诊断指标。
引文
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