2018年长春市及其周边地区15-70岁女性人乳头瘤病毒感染研究
|
摘要
目的了解长春市及其周边地区女性人乳头瘤病毒(HPV)感染状况。方法于2018年1-2月选取研究地区医院门诊就诊的15-70岁女性,采集宫颈脱落细胞,进行HPV基因分型检测,分析HPV感染率。结果长春市及其周边地区女性人群的HPV总感染率为30.23%(286/946)。≤25岁、26-35岁、36-45岁、46-55岁、≥56岁HPV感染率分别为50.48%、33.82%、22.38%、25.71%、28.85%。单一、双重、多重HPV感染率分别为17.23%、6.87%、6.13%。高危型HPV感染率在0.42%(HPV45)-4.65%(HPV52)之间。结论研究地区女性人群HPV感染率高,以年轻女性、单一高危型HPV感染为主。
Objective To determine the infection status of human papillomavirus(HPV) among women in Changchun city and surrounding areas. Methods We recruited 15-70 year old women from hospital outpatient clinics in the study area during JanuaryFebruary 2018 and collected cervical exfoliated cells from participants to determine HPV genotypes and analyze HPV infection rates. Results The overall HPV infection rate was 30.23%(286/946). HPV infection rates were 50.48%, 33.82%, 22.38%, 25.71%,and 28.85% for ≤25, 26-35, 36-45, 46-55, and ≥56 year old women, respectively. Single, double, and multiple HPV infection rates were 17.23%, 6.87%, and 6.13%, respectively. High-risk HPV infection rates ranged 0.42%(HPV45) to 4.65%(HPV52). Conclusion The HPV infection rate was high among women in the study area, particularly among young women; most infections were single genotype infections with high-risk HPV genotypes.
Objective To determine the infection status of human papillomavirus(HPV) among women in Changchun city and surrounding areas. Methods We recruited 15-70 year old women from hospital outpatient clinics in the study area during JanuaryFebruary 2018 and collected cervical exfoliated cells from participants to determine HPV genotypes and analyze HPV infection rates. Results The overall HPV infection rate was 30.23%(286/946). HPV infection rates were 50.48%, 33.82%, 22.38%, 25.71%,and 28.85% for ≤25, 26-35, 36-45, 46-55, and ≥56 year old women, respectively. Single, double, and multiple HPV infection rates were 17.23%, 6.87%, and 6.13%, respectively. High-risk HPV infection rates ranged 0.42%(HPV45) to 4.65%(HPV52). Conclusion The HPV infection rate was high among women in the study area, particularly among young women; most infections were single genotype infections with high-risk HPV genotypes.
引文
[1]BROTHERTON JML,GIULIANO AR,MARKOWITZLE,et al.Moni tor ing the impact of HPV vaccine in males-considerations and challenges[J].Papillomavirus Research,2016,2:106-111.
[2]吕建新,樊绮诗.临床分子生物学检验[M].第3版.北京:人民卫生出版社,2015:150-155.LV J,Fan YS.Clinical molecular biology test[M].3rd ed.Beijing:People's Medical Publishing House,2015:150-155.
[3]LORENZ TC.Polymerase chain reaction:basic protocol plus t roubleshooting and opt imizat ion st rategies[J].Journal of Visualized Experiments,2012,63:e3998.
[4]SCHIFFMAN M,CASTLE PE,JERONIMO J,et al.Human papillomavirus and cervical cancer[J].The Lancet,2007,370(9590):890-907.
[5]CLIFFORD GM,SMITH JS,PLUMMER M,et al.Human papillomavirus types in invasive cervical cancer worldwide:a meta-analysis[J].British Journal of Cancer,2003,88(1):63-73.
[6]BOSHART M,GISSMANN L,IKENBERG H,et al.A new type of papillomavirus DNA,its presence in genital cancer biopsies and in cell lines derived from cervical cancer[J].The EMBO Journal,1984,3(5):1151-1157.
[7]PARKIN MD,BRAY F,FERLAY J,et al.Estimating the world cancer burden:globocan 2000[J].International Journal of Cancer,2001,94(2):153-156.
[8]陈万青,张思维,曾红梅,等.中国2010年恶性肿瘤发病与死亡[J].中国肿瘤,2014,23(1):1-10.CHEN WQ,ZHANG SW,ZENG HM,et al.Repor t of cancer incidence and mortality in China,2010[J].China Cancer,2014,23(1):1-10.
[9]Hebner CA,Laimins LA.Human papillomaviruses:basic mechanisms of pathogenesis and oncogenicity[J].Reviews in Medical Virology,2006,16(2):83-97.
[10]MAKO NS,TOHRU K.Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis:roles of E6 and E7 proteins[J].Cancer Science,2007,98(10):1505-1511.
[11]郑红云,杨鹏,申复进,等.7746例妇女宫颈脱落细胞HPV基因分型结果研究[J].国际检验医学杂志,2017,38(24):3391-3392+3395.ZHENG HY,YANG P,SHEN FJ,et al.The research on HPV genotyping of cervical exfoliated cell from 7 746women[J].International Journal of Laboratory Medicine,2017,38(24):3391-3392+3395.
[12]DOREEN RM,CINDY MM,KURT TB,et al.Subtype distribution of human papillomavirus in HIV-inf ected women with cervical intraepithelial neoplasia stages 2 and3 in Botswana[J].Int J Gynecol Pathol,2011,30(6):591-596.
[13]EDYTA CP,BELEN L,ANCO M,et al.HPV prevalence and genotypes in dif ferent histological subtypes of cervical adenocarcinoma,a worldwide analysis of 760cases[J].Modern Pathology,2014,27(12):1559-1567.
[14]单玮,张涛,张铁军,等.我国女性人乳头瘤病毒(HPV)感染的流行病学现状[J].中华疾病控制杂志,2017,21(1):89-93.SHA N W,ZHA NG T,ZHANG T J,et al.The epidemiological si tuat ion of human pa pil lomavi rus infection among women in China[J].Chinese Journal of Disease Control&Prevention,2017,21(1):89-93.
[15]MUNOZ N,CASTELLSAGUéX,DE GONZáLEZ AB,et al.HPV in the etiology of human cancer[J].Vaccine,2006,24:S1-10.
[16]TOSHIYUKI S,HIROAKI T,SATORU M.Immune responses against human papillomavirus(HPV)infection and evasion of host defense in cervical cancer[J].J Infect Chemother,2012,18(6):807-815.
[17]EDUARDO LF,DIANE MH.Vaccination against human papillomavirus inf ection:a new paradigm in cervical cancer control[J].Vaccine,2005,23:2388-2394.
[18]綦小蓉,边策,赵霞.人乳头瘤病毒疫苗接种及研究现状[J].实用妇产科杂志,2016,32(11):818-822.QI XR,BIAN C,ZHAO X.Vaccina t ion of human papillomavirus and its research status[J].Journal of Practical Obstetrics and Gynecology,2016,32(11):818-822.
[19]李芹,刘春容,李静.世界范围内9~26岁女性对HPV的认知现状及预防性HPV疫苗的应用现况[J].中国肿瘤,2017,26(3):161-169.LI Q,LIU CR,LI J.HPV-related knowledge a nd application of HPV among female aged 9 to 26 worldwide[J].China Cancer,2017,26(3):161-169.
[2]吕建新,樊绮诗.临床分子生物学检验[M].第3版.北京:人民卫生出版社,2015:150-155.LV J,Fan YS.Clinical molecular biology test[M].3rd ed.Beijing:People's Medical Publishing House,2015:150-155.
[3]LORENZ TC.Polymerase chain reaction:basic protocol plus t roubleshooting and opt imizat ion st rategies[J].Journal of Visualized Experiments,2012,63:e3998.
[4]SCHIFFMAN M,CASTLE PE,JERONIMO J,et al.Human papillomavirus and cervical cancer[J].The Lancet,2007,370(9590):890-907.
[5]CLIFFORD GM,SMITH JS,PLUMMER M,et al.Human papillomavirus types in invasive cervical cancer worldwide:a meta-analysis[J].British Journal of Cancer,2003,88(1):63-73.
[6]BOSHART M,GISSMANN L,IKENBERG H,et al.A new type of papillomavirus DNA,its presence in genital cancer biopsies and in cell lines derived from cervical cancer[J].The EMBO Journal,1984,3(5):1151-1157.
[7]PARKIN MD,BRAY F,FERLAY J,et al.Estimating the world cancer burden:globocan 2000[J].International Journal of Cancer,2001,94(2):153-156.
[8]陈万青,张思维,曾红梅,等.中国2010年恶性肿瘤发病与死亡[J].中国肿瘤,2014,23(1):1-10.CHEN WQ,ZHANG SW,ZENG HM,et al.Repor t of cancer incidence and mortality in China,2010[J].China Cancer,2014,23(1):1-10.
[9]Hebner CA,Laimins LA.Human papillomaviruses:basic mechanisms of pathogenesis and oncogenicity[J].Reviews in Medical Virology,2006,16(2):83-97.
[10]MAKO NS,TOHRU K.Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis:roles of E6 and E7 proteins[J].Cancer Science,2007,98(10):1505-1511.
[11]郑红云,杨鹏,申复进,等.7746例妇女宫颈脱落细胞HPV基因分型结果研究[J].国际检验医学杂志,2017,38(24):3391-3392+3395.ZHENG HY,YANG P,SHEN FJ,et al.The research on HPV genotyping of cervical exfoliated cell from 7 746women[J].International Journal of Laboratory Medicine,2017,38(24):3391-3392+3395.
[12]DOREEN RM,CINDY MM,KURT TB,et al.Subtype distribution of human papillomavirus in HIV-inf ected women with cervical intraepithelial neoplasia stages 2 and3 in Botswana[J].Int J Gynecol Pathol,2011,30(6):591-596.
[13]EDYTA CP,BELEN L,ANCO M,et al.HPV prevalence and genotypes in dif ferent histological subtypes of cervical adenocarcinoma,a worldwide analysis of 760cases[J].Modern Pathology,2014,27(12):1559-1567.
[14]单玮,张涛,张铁军,等.我国女性人乳头瘤病毒(HPV)感染的流行病学现状[J].中华疾病控制杂志,2017,21(1):89-93.SHA N W,ZHA NG T,ZHANG T J,et al.The epidemiological si tuat ion of human pa pil lomavi rus infection among women in China[J].Chinese Journal of Disease Control&Prevention,2017,21(1):89-93.
[15]MUNOZ N,CASTELLSAGUéX,DE GONZáLEZ AB,et al.HPV in the etiology of human cancer[J].Vaccine,2006,24:S1-10.
[16]TOSHIYUKI S,HIROAKI T,SATORU M.Immune responses against human papillomavirus(HPV)infection and evasion of host defense in cervical cancer[J].J Infect Chemother,2012,18(6):807-815.
[17]EDUARDO LF,DIANE MH.Vaccination against human papillomavirus inf ection:a new paradigm in cervical cancer control[J].Vaccine,2005,23:2388-2394.
[18]綦小蓉,边策,赵霞.人乳头瘤病毒疫苗接种及研究现状[J].实用妇产科杂志,2016,32(11):818-822.QI XR,BIAN C,ZHAO X.Vaccina t ion of human papillomavirus and its research status[J].Journal of Practical Obstetrics and Gynecology,2016,32(11):818-822.
[19]李芹,刘春容,李静.世界范围内9~26岁女性对HPV的认知现状及预防性HPV疫苗的应用现况[J].中国肿瘤,2017,26(3):161-169.LI Q,LIU CR,LI J.HPV-related knowledge a nd application of HPV among female aged 9 to 26 worldwide[J].China Cancer,2017,26(3):161-169.