3D打印工艺参数对组织工程支架微观结构的影响研究
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摘要
挤出式3D打印是制备组织工程支架的重要技术手段之一.一个性能良好的组织工程支架必须具备小孔隙、高孔隙率的内部微观结构.针对挤出式3D打印支架成形动态过程,建立了打印材料成形过程热-力耦合动力学模型,并通过数值模拟研究了主要打印工艺参数对支架成形的孔隙尺寸、材料重熔特性的影响.结果表明,支架的孔隙尺寸随打印时间间隔和材料粘度的增大而增大,但随基板温度的升高而降低;支架重熔度与孔隙尺寸变化趋势相反;其中材料粘度的变化对成形支架的孔隙尺寸和重熔度的影响最为明显.
Extrusion-based 3D printing is one of the most important techniques for preparing tissue engineering scaffolds.A well-performed tissue engineering scaffold must have an internal microstructure with small pores and high porosity.A thermo-mechanical coupling dynamics model of printing material forming process is established for the scaffold forming dynamic process in extrusion-based 3D printing.The influence of the main parameters in printing process on the pore size and remelting properties of the formed scaffold is studied by numerical simulation.The results show that the pore size of the scaffold increases with both the printing time interval and material viscosity increasing,but with the substrate temperature decreasing while the results of the remelting degree of the scaffold is competely opposite;and the change of material viscosity has the most obvious influence on the pore size and remelting degree of the scaffold formed.
Extrusion-based 3D printing is one of the most important techniques for preparing tissue engineering scaffolds.A well-performed tissue engineering scaffold must have an internal microstructure with small pores and high porosity.A thermo-mechanical coupling dynamics model of printing material forming process is established for the scaffold forming dynamic process in extrusion-based 3D printing.The influence of the main parameters in printing process on the pore size and remelting properties of the formed scaffold is studied by numerical simulation.The results show that the pore size of the scaffold increases with both the printing time interval and material viscosity increasing,but with the substrate temperature decreasing while the results of the remelting degree of the scaffold is competely opposite;and the change of material viscosity has the most obvious influence on the pore size and remelting degree of the scaffold formed.
引文
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[4]吴述平,龚兴厚,张裕刚,等.组织工程用可生物降解聚合物多孔支架制备方法研究进展[J].高分子通报,2010(5):61-66.
[5]经鑫,彭响方.生物可降解聚合物多孔支架的制备研究进展[J].中国塑料,2012,26(2):1-6.
[6]Hieu L G,Zlatov N,Sloten V,et al.Medical Rapid Prototyping Applications Andmethods[J].Rapid Prototyping Journal,2005,25(4):284-292.
[7]贺超良,汤朝晖,田华雨,等.3D打印技术制备生物医用高分子材料的研究进展[J].高分子学报,2013,52(6):722-732.
[8]魏学磊,董福慧.计算机辅助成型技术制备骨组织工程支架的研究进展[J].中国修复重建外科杂志,2011,25(12):1508-1512.
[9]洪亚威,李少波,刘广,等.以废旧PET为线材的新型3D打印喷头设计研究[J].南昌工程学院学报,2017,36(4):86-89.
[10]曾祥辉,齐乐华,蒋小珊,等.金属熔滴与基板碰撞变形的数值模拟[J].哈尔滨工业大学学报,2011,43(3):70-74.
[11]Li H,Wang P,Qi L,et al.3DNumerical Simulation of Successive Deposition of Uniform Molten Al Droplets on a Moving Substrate and Experimental Validation[J].Computational Materials Science,2012,65(4):291-301.
[12]Brackbill J U,Kothe D B,Zemach C.A Continuum Method for Modeling Surface Tension[J].Journal of Computational Physics(S0021-9991),1992,100(2):335-354.
[13]李谊乐,刘应中.二阶精度的VOF自由面追踪方法及其应用[J].船舶力学,1999,3(1):44-52.
[14]张健,方杰,范波芹.VOF方法理论与应用综述[J].水利水电科技进展,2005,25(2):67-70.
[15]李素丽,刘伟.基于传热凝固模型金属熔体滴落、铺展温度变化分析[J].材料导报,2014,28(18):144-148.
[16]Chao Y P,Qi L H,Zuo H S,et al.Remelting and Bonding of Deposited Aluminum Alloy Droplets under Different Droplet and Substrate Temperatures in Metal Droplet Deposition Manufacture[J].International Journal of Machine Tools&Manufacture,2013,69(3):38-47.