淫羊藿苷对骨质疏松状态下钛种植体骨整合的影响
摘要
目的利用淫羊藿苷注入到骨质疏松钛种植体的动物体中,观察淫羊藿苷对动物体种植体骨整合的效果。方法从中山大学实验动物中心购买纯种雌性8个月大的时候新西兰兔30只,随机分为对照组、模型组和淫羊藿苷三组,对照组仅去除新西兰兔胫骨周围两边的脂肪组织,模型组、淫羊藿苷全部切除卵巢两侧的新西兰兔胫骨,并建立新西兰兔骨质疏松症模型。在骨质疏松症模型手术3个月后,所有三组都在新西兰兔的左侧胫骨近中干髓端植入纯钛种植体。种植牙植入后的第一天,淫羊藿苷组开始对新西兰兔注入淫羊藿苷,淫羊藿苷溶液比根据0.15 g.kg-1比例融入到10毫升生理盐水中配置淫羊藿苷化合物,每天灌服一次,而假手术组和模型组分别采取同等剂量的生理盐水,植入种植后,1月、2月、3月获得三组新西兰兔的胫骨,同时制作骨组织形态学染色组织学切片,进行骨组织形态学观察,并进行比较。结果术前3个月,骨质疏松模型合淫羊藿苷组动物饮食明显增加,体重也在迅速增加,动物骨密度(BMD)值的模型组明显低于假手术组,植入种植体一个月后,模型组在松质骨周围植入区域(Tb Ar),骨小梁(Tb Wium)的平均密度,骨板宽度(CBLWum)明显低于其他两组(P<0.05)。1月、2月、3月后淫羊藿苷组的Tb Ar、Tb Wium、CBLWum均高于模型组(P<0.05)。结论淫羊藿苷能快速提高骨质疏松动物的纯钛种植体的骨结合率,增加骨面积和骨板宽度,促进骨移植愈合率。
引文
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[16]文娱,张金娟,陈雪梅,任光友,张贵林.淫羊藿苷对骨质疏松模型新西兰兔骨组织中IL-6表达的影响[J].贵州医药,2010,34(9):781-783.
[2]Russell LA.Osteoporosis and orthopedic surgery:effect of bone health on total joint a Ttlu'oplasty outcome[J].Curr Rheumatol Rep,2013,11:371.
[3]Tarakida A,Higuchi T,Mizunuma H.[Evidence of hormone replacement therapy for osteoporosis].Clin Calcium,2008,18(10):1434-1441.
[4]Palacios S.Advances in hormone replacement therapy:making the menopause manageable.BMC Women's Health,2008,8(1):22.
[5]侯玉东,余萍萍,韩晓鹏,等.雌激素干预吸烟骨质疏松大新西兰兔种植体周围的骨沉积[J].中国组织工程研究,2012,16(46):8556-8560.
[6]Minsk L,Polson AM.Dental implant outcomes in postmenopausal women undergoing hormone replacement.Compend Contin Educ Dent,2014,19(9):859-862.
[7]Wang Y,Yang X,Li X,et al.Knowledge and personal use of menopausal hormone therapy among Chinese obstetrician-gynecologists:results of a survey.Menopause,2014,54,395.
[8]Dikicier E,Kara?ayl?ü,Dikicier S,et al.Effect of systemic administered zoledronic acid on osseointegration of a titanium implant in ovariectomized rats.J Craniomaxillofac Surg,2014,5(14):9.
[9]张玉芹,邓久鹏,戚孟春,等.局部应用唑来膦酸对骨质疏松大新西兰兔种植体骨结合的影响[J].中国老年学杂志,2012,32(15):3227-3229.
[10]李春艳,周延民,王林,等.阿仑膦酸钠对骨质疏松种植体骨结合影响的力学研究[J].华西口腔医学杂志,2011,29(3):328-329.
[11]Brown JP,Morin S,Leslie W,et al.Bisphosphonates for treatment of osteoporosis Expected benefits,potential harms,and drug holidays.Can Fam Physician,2014,60(4):324-333.
[12]李国宾,贾素侠,陈旻生,等.辛伐他汀对骨质疏松患者种植体周围骨的影响[J].中国实用医药,2012,7(18):49-50.
[13]Ahn SJ,Leesungbok R,Lee SW,et al.Differences in implant stability associated with various methods of preparation of the implant bed:An in vitro study.J Prosthet Dent,2012,107(6):366-372.
[14]Danoux CB,Barbieri D,Yuan H,et al.In vitro and in vivo bioactivity assessment of a polylactic acid/hydroxyapatite composite for bone regeneration.Biomatter,2014,4(1):27.
[15]张帆,陈晖,程志鹏.加速口腔种植体愈合的相关性研究现状[J].全科医学临床与教育,2009,7(5):503-505.
[16]文娱,张金娟,陈雪梅,任光友,张贵林.淫羊藿苷对骨质疏松模型新西兰兔骨组织中IL-6表达的影响[J].贵州医药,2010,34(9):781-783.
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