rt-PA与尿激酶静脉溶栓治疗不同时间窗急性脑梗死的疗效分析

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英文篇名：The effect of rt-PA and urokinase intravenous thrombolytic therapy for actue cerebral infarction within different time windows 作者：高想杰 ; 任丽华 英文作者：GAO Xiangjie;REN Lihua;Department of Neurology,The Yong Chuan Hospital of Chongqing Medical University; 关键词：急性脑梗死 ; 不同时间 ; 静脉溶栓 ; rt-PA ; 尿激酶 英文关键词：Acute cerebral infarction;;Different time windows;;Intravenous thrombolysis;;rt-PA;;Urokinase 中文刊名：ZFSJ 英文刊名：Journal of Apoplexy and Nervous Diseases 机构：重庆医科大学附属永川医院神经内科; 出版日期：2019-06-30 出版单位：中风与神经疾病杂志 年：2019 期：v.36;No.250 语种：中文; 页：ZFSJ201906012 页数：3 CN：06 ISSN：22-1137/R 分类号：41-43

摘要

目的探讨rt-PA与尿激酶静脉溶栓治疗不同时间窗急性脑梗死的临床疗效。方法选取重庆医科大学附属永川医院神经内科2018年1月-2018年12月期间收治的急性脑梗死患者143例,按照溶栓使用药物分为重组组织型纤溶酶原激活剂(rt-PA)组和尿激酶组,按照发病到静脉溶栓时间(time,简称t)可分为6组:分别为t≤1 h、1         Objective To evaluate the effect of rt-PA and urokinase intravenous thrombolytic therapy for actue cerebral infarction within different time windows. Methods From January to December 2018,143 patients with acute cerebral infarction admitted to the Department of Neurology,The Yong Chuan Hospital of Chongqing Medical University were selected.They were divided into recombinant tissue plasminogen activators( rt-PA) group and urokinase group according to the drugs used in thrombolysis. According to thrombolytic time( time,t),they can be divided into 6 groups: t≤1 h,1 < t≤2 h,2 < t≤3 h,3 < t≤4 h,4 < t≤5 h and 5 < t≤6 h. All patients enrolled in the study were given intravenous thrombolysis treatment in the time window,and recorded the NIHSS score before thrombolysis、24 h after thrombolysis、7 ± 2 d after thrombolysis and complications after thrombolysis. Results Before thrombolysis,the NIHSS score of rt-PA group and urokinase group was not statistically significant,and the NIHSS score of 24 h after thrombolysis and 7 ± 2 d after thrombolysis were all reduced to different degrees. The difference was statistically significant. However,there was no significant difference between rt-PA group and urokinase group in thrombolytic efficacy and complications. The difference of thrombolytic effect and the number of complications among 6 groups( t≤1 h,1 < t≤2 h,2 < t≤3 h,3 < t≤4 h,4 < t≤5 h,5 < t≤6 h) is statistically significant.Conclusions When acute cerebral infarction occurs,whether it is urokinase or rt-PA,intravenous thrombolysis should be given as soon as possible,and the earlier the thrombolysis,the better the efficacy,and the fewer complications of the merger.

引文

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