银黄可溶性粉对肉鸡人工感染IBDV防治效果的研究
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摘要
考察银黄可溶性粉对鸡传染性法氏囊病的防治作用。以黄羽肉鸡为实验动物,按疗程饲喂高、中、低剂量的银黄可溶性粉,饲喂药物后第4天接种IBDV强毒,对攻毒后鸡死亡数、增重、剖检病变、免疫器官指数及IBD抗体等指标进行统计和分析。结果表明,在22日龄时,银黄可溶性粉以高剂量(每只鸡每天饲喂1.75 g)、中剂量(每只鸡每天饲喂1.0 g)饲喂3个疗程,对人工感染IBDV强毒的鸡群,保护率高于90%,有显著的防治效果,还能显著降低IBDV对鸡只增重的影响和对鸡法氏囊、胸腺和脾脏等免疫器官的损伤,且能减轻IBDV引起的机体免疫抑制,提高血清中的抗体水平。
In order to investigate the effects of prevention and treatment of Yinhuang soluble powder on infectious bursal disease in chicken,yellow feather broilers were feed with high,medium and low doses of Yinhuang soluble powder according to the treatment course.The broilers were challenged by highly virulent strain IBDV at the 4 th day after feeding the medicine.The mortality,weight gain,pathological changes,immune organ index and IBDV antibody were analyzed. The results showed that at the age of 22 days,the Yinhuang soluble powder was fed with high dose(1.75 g per chicken per day) and medium dose(1.0 g per chicken per day) for three courses of treatment,the protective rate of chickens infected artificially with IBDV was higher than 90%. It had obvious prevention and treatment effect. It could also significantly reduce the impact of IBDV on weight gain in chickens and the damage to immune organs such as bursa of fabricius,thymus and spleen. It could also alleviate the immune suppression induced by IBDV and increase the level of antibody in serum.
In order to investigate the effects of prevention and treatment of Yinhuang soluble powder on infectious bursal disease in chicken,yellow feather broilers were feed with high,medium and low doses of Yinhuang soluble powder according to the treatment course.The broilers were challenged by highly virulent strain IBDV at the 4 th day after feeding the medicine.The mortality,weight gain,pathological changes,immune organ index and IBDV antibody were analyzed. The results showed that at the age of 22 days,the Yinhuang soluble powder was fed with high dose(1.75 g per chicken per day) and medium dose(1.0 g per chicken per day) for three courses of treatment,the protective rate of chickens infected artificially with IBDV was higher than 90%. It had obvious prevention and treatment effect. It could also significantly reduce the impact of IBDV on weight gain in chickens and the damage to immune organs such as bursa of fabricius,thymus and spleen. It could also alleviate the immune suppression induced by IBDV and increase the level of antibody in serum.
引文
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[3]丁淑敏,肖娜.鸡传染性法氏囊病的诊断和中药方剂预防[J].现代畜牧科技,2016,19(7):85-86.
[4]徐建忠,邓鑫鑫,史秋梅,等.紫黄散对人工感染传染性法氏囊病病毒雏鸡血液生化指标的影响[J].动物医学进展,2010,31(6):53-57.
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[6]刘俊烨.复方中草药对鸡传染性法氏囊病的防治实验研究[D].福州:福建农林大学,2012.
[7]余广海.抗病毒中药在畜禽疫病防控中的应用[J].四川畜牧兽医,2017,327(11):46-47.
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[9]侯晓礁,王秀敏.银黄可溶性粉对鸡毒支原体感染的治疗效果[C]//中国畜牧兽医学会.中国畜牧兽医学会2009学术年会论文集(下册).石家庄:中国畜牧兽医学会,2009.
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[11]朱子洁,尤永君,苏霞,等.鸡传染性法氏囊病疫苗对SPF鸡ND免疫效果的影响[J].动物医学进展,2010,31(S):132-134.
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[13]董淑云.药理实验方法学[M].2版.北京:人民卫生出版社,1989:670-673
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[15]祝建新,朱印生.中草药防治人工感染鸡法氏囊病效果及有关指标的观察[J].中兽医学杂志,1995(2):3-7.
[16]涂幸福,梁道景.三黄金花散对人工感染鸡传染性法氏囊病的治疗实验[J].乡村科技,2016(15):28-29.
[17]Ding Y,Dou J,Teng Z,et a1.Antiviral activity of baicalin against influenza A(H1N1/H3N2)virus in cell culture and in mice and its inhibition of neuram inidase[J].Archives of virology,2014(159):3269-3278.
[18]王振中,鲍琳琳,孙兰,等.热毒宁注射液抗甲型H1N1流感病毒作用机制研究[J].中草药,2014,45(1):90-93.
[19]林思望,陈元其.中草药对鸡临床法氏囊病的疗效及免疫作用研究[J].中兽医学杂志,2004(6):8-10.
[20]牟明生,张祥,毛胜勇,等.芩对肉鸡生长性能及回盲肠微生物菌群的影响[J].畜牧与兽医,2010,42(5):5-8.
[21]徐斌武.金银花在肉鸡饲料中的应用效果研究[J].中兽医医药杂志,2014,33(2):8-10.
[22]冯善祥.复方金银花对雏鸡法氏囊强毒抑制效果观察实验[J].中国动物检疫,2010,27(11):55-57.
[23]Rivas A,Fabricant J.Indication of immunodepression in chiken infected with various strain of Marek's disease virus[J].Avian Disease,1985(32):1-8.
[24]张强,李明哲,杨宗让.绵马贯众可溶性粉对人工感染鸡传染性法氏囊病的疗效评价[J].中国畜牧兽医,2014(41):242-245.
[25]祝国强,侯风琴,钟翠红,等.银翘黄连解毒汤对鸡传染性法氏囊病的防治实验[J].中国兽医杂志,2008(44):53-54.
[26]张栋,刘俊栋,王振勇.复方中药“毒菌杀”对鸡传染性法氏囊炎的防治实验[J].现代畜牧兽医,2005(12):40-41.
[2]Ou C B,Shi N N,Pan Q,et al.Therapeutic efficacy of the combined extract of herbal medicine against infectious bursal disease in chickens[J].Pakistan Veterinary Journal,2013,33(3):304-308.
[3]丁淑敏,肖娜.鸡传染性法氏囊病的诊断和中药方剂预防[J].现代畜牧科技,2016,19(7):85-86.
[4]徐建忠,邓鑫鑫,史秋梅,等.紫黄散对人工感染传染性法氏囊病病毒雏鸡血液生化指标的影响[J].动物医学进展,2010,31(6):53-57.
[5]王海龙,王海凤,李杏媛,等.玉屏分散对雏鸡传染性法氏囊病疫苗免疫效果的影响[J].畜牧兽医学报,2009,40(10):1564-1568.
[6]刘俊烨.复方中草药对鸡传染性法氏囊病的防治实验研究[D].福州:福建农林大学,2012.
[7]余广海.抗病毒中药在畜禽疫病防控中的应用[J].四川畜牧兽医,2017,327(11):46-47.
[8]侯晓礁,王万里,王秀敏.银黄可溶性粉对人工感染鸡大肠杆菌病的防治效果[C]//中国畜牧兽医学会.中国畜牧兽医学会2009学术年会论文集(下册).石家庄:中国畜牧兽医学会,2009.
[9]侯晓礁,王秀敏.银黄可溶性粉对鸡毒支原体感染的治疗效果[C]//中国畜牧兽医学会.中国畜牧兽医学会2009学术年会论文集(下册).石家庄:中国畜牧兽医学会,2009.
[10]中国兽药典委员会.中华人民共和国兽药典·2015年版[S].北京:中国农业出版社,2016.
[11]朱子洁,尤永君,苏霞,等.鸡传染性法氏囊病疫苗对SPF鸡ND免疫效果的影响[J].动物医学进展,2010,31(S):132-134.
[12]祝建新,朱印生.中草药防治鸡人工感染传染性法氏囊病的实验研究[J]中兽医学杂志,1994,75(2):1-4.
[13]董淑云.药理实验方法学[M].2版.北京:人民卫生出版社,1989:670-673
[14]孙秀红.中草药防治鸡传染性法氏囊病[J].中兽医医药杂志,2002,21(1):39.
[15]祝建新,朱印生.中草药防治人工感染鸡法氏囊病效果及有关指标的观察[J].中兽医学杂志,1995(2):3-7.
[16]涂幸福,梁道景.三黄金花散对人工感染鸡传染性法氏囊病的治疗实验[J].乡村科技,2016(15):28-29.
[17]Ding Y,Dou J,Teng Z,et a1.Antiviral activity of baicalin against influenza A(H1N1/H3N2)virus in cell culture and in mice and its inhibition of neuram inidase[J].Archives of virology,2014(159):3269-3278.
[18]王振中,鲍琳琳,孙兰,等.热毒宁注射液抗甲型H1N1流感病毒作用机制研究[J].中草药,2014,45(1):90-93.
[19]林思望,陈元其.中草药对鸡临床法氏囊病的疗效及免疫作用研究[J].中兽医学杂志,2004(6):8-10.
[20]牟明生,张祥,毛胜勇,等.芩对肉鸡生长性能及回盲肠微生物菌群的影响[J].畜牧与兽医,2010,42(5):5-8.
[21]徐斌武.金银花在肉鸡饲料中的应用效果研究[J].中兽医医药杂志,2014,33(2):8-10.
[22]冯善祥.复方金银花对雏鸡法氏囊强毒抑制效果观察实验[J].中国动物检疫,2010,27(11):55-57.
[23]Rivas A,Fabricant J.Indication of immunodepression in chiken infected with various strain of Marek's disease virus[J].Avian Disease,1985(32):1-8.
[24]张强,李明哲,杨宗让.绵马贯众可溶性粉对人工感染鸡传染性法氏囊病的疗效评价[J].中国畜牧兽医,2014(41):242-245.
[25]祝国强,侯风琴,钟翠红,等.银翘黄连解毒汤对鸡传染性法氏囊病的防治实验[J].中国兽医杂志,2008(44):53-54.
[26]张栋,刘俊栋,王振勇.复方中药“毒菌杀”对鸡传染性法氏囊炎的防治实验[J].现代畜牧兽医,2005(12):40-41.
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