黄连解毒汤联合三氧化二砷冻干粉针剂治疗中晚期原发性肝癌临床观察
摘要
目的:探讨黄连解毒汤联合三氧化二砷冻干粉针治疗中晚期原发性肝癌的临床疗效。方法:将符合诊断标准的34例原发性肝癌患者分为治疗组和对照组,治疗组给予黄连解毒汤和As2O3冻干粉针剂治疗,对照组单纯应用As2O3冻干粉针剂治疗,观察两组临床疗效、患者生活质量及不良反应。结果:两组治疗后缓解率及疾病进展率无明显差异,但治疗组缓解率有升高趋势,且KPS评分改善比率较对照组明显升高,有统计学差异(P<0.05)。两组患者毒性反应均较小,患者耐受度良好。结论:黄连解毒汤联合三氧化二砷冻干粉针治疗中晚期原发性肝癌具有一定的临床疗效。
引文
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[23]钱军,秦叔逵,何泽明,等.三氧化二砷注射液治疗中晚期原发性肝胆癌的临床研究[J].中华肿瘤杂志,2001,23(6):487-489.
[24]郭换珍,赵直光,唐中权,等.三氧化二砷治疗晚期原发性肝癌的临床观察[J].中国肝脏病杂志(电子版),2014,6(1):5-7.
[2]Jeong SO,Kim EB,Jeong SW,et al.Predictive factors for complete response and recurrence after transarterial chemoembolization in hepatocellular carcinoma[J].Gut Liver,2017,2:1-9.
[3]Chen H,Gao S,Yang XZ,et al.Comparison of safety and efficacy of different models of target vessel regional chemotherapy for gastric cancer with liver metastases[J].Chemotherapy,2016,61(2):99-107.
[4]Lv XH,Wang CH,Xie Y.Arsenic trioxide combined with transarterial chemoembolization for primary liver cancer:A meta-analysis[J].J Gastroenterol Hepatol,2017,32(9):1 540-1 547.
[5]Wang L,Wang R,Fan L.Arsenic trioxide is an immune adjuvant in liver cancer treatment[J].Mol Immunol,2017,81:118-126.
[6]Cui L,Gao B,Cao Z,et al.Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide[J].Mol Med Rep,2016,13(3):2 032-2 038.
[7]屈凤莲,郝学志,秦叔逵,等.亚砷酸注射液治疗原发性肝癌的Ⅱ期多中心临床研究[J].中华肿瘤杂志,2011,33(9):697-701.
[8]Bie B,Sun J,Guo Y,et al.Baicalein:A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma[J].Biomed Pharmacother,2017,93:1 285-1 291.
[9]Wang N,Feng Y,Tan HY,et al.Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma[J].J Ethnopharmacol,2015,164:309-318.
[10]中国抗癌协会肝癌专业委员会.原发性肝癌诊断标准[J].中华肝脏病杂志,2000,8(3):135.
[11]Miller AB,Hoogstraten B,Staquet M,et al.Reporting results of cancer treatment[J].Cancer,1981,47:207-214.
[12]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:48.
[13]抗癌药急性及亚急性毒性反应分度标准(WHO标准)[J].癌症,1992(3):254.
[14]Livragh T,Makisalo H,Line PD.Treatment options in hepatocellular carcinoma today[J].Scand J Surg,2011,100(1):22-29.
[15]Jarnagin WR.Management of small hepotocellular carcinoma:a review of transplantation,resection,and ablation[J].Ann Surg Oncol,2010,17(5):1 226-1 233.
[16]Cohen GS,Black M.Multidisciplinary management of hepatocellular carcinoma:a model for therapy[J].J Multidiscip Healthc,2013,6(3):189-195.
[17]方雪琴.黄连解毒汤药理作用研究进展[J].中成药,2015,37(10):2 254-2 258.
[18]张梦月,孙燕,于宁,等.黄连解毒汤对S180肉瘤、MVD及VEGF、MMP-9表达的影响[J].沈阳医学院学报,2017,19(2):178-181,188.
[19]孙健,温庆辉,宋宇,等.黄连解毒汤抗肿瘤作用的实验研究[J].中国中药杂志,2006,31(17):1 461-1 463.
[20]Hsu YL,Kuo PL,Tzeng TF,et al.Huang-lian-jie-du-decoction,a traditional Chinese medicine prescription,induces cellcycle arrest and apoptosis in human liver cancer cells in vitro and in vivo.J Gastroenterol Hepatol.2008,23(7):e290–9.
[21]Ma Z,Otsuyama K,Liu S,et al.Baicalein,a component of Scutellaria radix from Huang-Lian-Jie-Du-decoction(HLJDT),leads to suppression of proliferation and induction of apoptosis in human myeloma cells.Blood.2005(105):3312–8.
[22]周阿高,张勇,孔德云,等.黄连解毒汤对荷瘤小鼠免疫调节作用的实验研究[J].中国实验方剂学杂志,2007,13(3):56-58.
[23]钱军,秦叔逵,何泽明,等.三氧化二砷注射液治疗中晚期原发性肝胆癌的临床研究[J].中华肿瘤杂志,2001,23(6):487-489.
[24]郭换珍,赵直光,唐中权,等.三氧化二砷治疗晚期原发性肝癌的临床观察[J].中国肝脏病杂志(电子版),2014,6(1):5-7.
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