2-氯-3,4-二甲氧基苯甲醛的合成研究

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英文篇名：Synthesis of 2-chloro-3,4-dimethoxybenzaldehyde 作者：徐玉美 ; 曹文贵 ; 阿尔腾其其格 ; 仝红娟 英文作者：XU Yu-mei;CAO Wen-gui;AERTENG Qi-qi-ge;TONG Hong-juan;School of Pharmacy,Shaanxi Institute of International Trade & Commerce;Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province; 关键词：3 ; 4-二甲氧基苯甲醛 ; 2-氯-3 ; 4-二甲氧基苯甲醛 ; 氯代反应 ; 合成 英文关键词：3,4-dimethoxybenzaldehyde;;2-chloro-3,4-dimethoxybenzaldehyde;;chlorination reaction;;synthsis 中文刊名：JXHX 英文刊名：Fine and Specialty Chemicals 机构：陕西国际商贸学院医药学院;陕西省中药绿色制造技术协同创新中心; 出版日期：2019-03-21 出版单位：精细与专用化学品 年：2019 期：v.27 基金：国家级大学生创新创业项目(201849002) 语种：中文; 页：JXHX201903010 页数：3 CN：03 ISSN：11-3237/TQ 分类号：27-29

摘要

以3,4-二甲氧基苯甲醛为原料,在二氯亚砜作用下,一步反应合成得到目标产物2-氯-3,4-二甲氧基苯甲醛,其结构经1 HNMR和GC-MS确证。对影响目标产物收率的因素进行了考察,确定的最佳反应条件为:物料n(3,4-二甲氧基苯甲醛)∶n(二氯亚砜)=1∶1.3,反应溶剂为二氯甲烷,反应温度为-30℃,反应时间为16h。在此最佳反应条件下,目标产物的收率为63.4%。
        2-Chloro-3?4-dimethoxybenzaldehyde was synthesized from 3?4-dimethoxybenzaldehyde in the presence of SOCl_2 by a one-step reaction.The structure of the product was confirmed by ~1HNMR and ESI-MS.The optimal reaction conditions were also investigated,n(3?4-dimethoxybenzaldehyde)∶n(SOCl_2)=1∶1.3;CH_2Cl_2 as solvent;the target compound was obtained in a yield of 63.4% at-30℃ for 16 h.

引文

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