含酸敏感化学键的pH敏感性脂质体在肿瘤治疗中研究进展
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摘要
<正>化学药物治疗简称化疗,是癌症治疗的有效手段之一,阿霉素(doxorubicin,DOX)、紫杉醇(paclitaxel,PTX)等用于化疗的细胞毒性物质可显著改善癌症患者的生活质量~([1])。但多数成药的细胞毒性成分对肿瘤细胞选择性差,且存在非靶向性的全身副作用。迄今为止,这些问题仍然是化学治疗的主要瓶颈~([2])。为了提高肿瘤细胞选择性,改善抗癌疗效,多功能纳米系统研发受到了普遍关注~([3])。常见的药物递送系统包括:胶束~([4])、脂质体~([5])、金属纳米粒子~([6])、二氧
引文
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[26]Zhang L,Wang Y,Yang Y,et al.High tumor penetration of paclitaxel loaded pH sensitive cleavable liposomes by depletion of tumor collagen I in breast cancer.ACS Appl Mater Interfaces,2015,7(18):9691-9701.
[27]Xiang B,Jia XL,Qi JL,et al.Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptidemodified liposomal system.Int J Nanomedicine,2017,12:2385-2405.
[28]Oude Blenke E,Sleszynska M,Evers MJ,et al.Strategies for the activation and release of the membranolytic peptide melittin from liposomes using endosomal pH as a trigger.Bioconjug Chem,2017,28(2):574-582.
[29]Huang Z,Guo X,Li W,et al.Acid-triggered transformation of diortho ester phosphocholine liposome.J Am Chem Soc,2006,128(1):60-61.
[30]Guo X,MacKay JA,Szoka FC Jr.Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid.Biophys J,2003,84(3):1784-1795.
[31]Kanamala M,Palmer BD,Ghandehari H,et al.PEG-benzaldehyde-hydrazone-lipid based PEG-sheddable p H-sensitive liposomes:abilities for endosomal escape and long circulation.Pharm Res,2018,35(8):154.
[32]Nie Y,Günther M,Gu Z,et al.Pyridylhydrazone-based PEGylation for pH-reversible lipopolyplex shielding.Biomaterials,2011,32(3):858-869.
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[34]Kim HK,Thompson DH,Jang HS,et al.pH-responsive biodegradable assemblies containing tunable phenyl-substituted vinyl ethers for use as efficient gene delivery vehicles.ACS Appl Mater Interfaces,2013,5(12):5648-5658.
[35]Scomparin A,Florindo HF,Tiram G,et al.Two-step polymer-and liposome-enzyme prodrug therapies for cancer:PDEPT and PELTconcepts and future perspectives.Adv Drug Deliver Rev,2017,118:52-64.
[36]Luo Z,Cai K,Hu Y,et al.Mesoporous silica nanoparticles end-capped with collagen:redox-responsive nanoreservoirs for targeted drug delivery.Angew Chem Int Ed Engl,2011,50(3):640-643.
[37]Berndt I,Popescu C,Wortmann FJ,et al.Mechanics versus thermodynamics:swelling in multiple-temperature-sensitive core-shell microgels.Angew Chem Int Ed Engl,2006,45(7):1081-1085.
[38]Yan F,Li L,Deng Z,et al.Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers.J Control Release,2013,166(3):246-255.
[39]Ercole F,Davis TP,Evans RA.Photo-responsive systems and biomaterials:photochromic polymers,light-triggered self-assembly,surface modification,fluorescence modulation and beyond.Polym Chem,2010,1:37-54.
[40]Zhang CY,Wu D,Lu LJ,et al.Multifunctional hybrid liposome as a theranostic platform for magnetic resonance imaging guided photothermal therapy.ACS Biomater Sci Eng,2018,4(7):2597-2605.
[41]Zhang WL,Choi HJ.Fast and facile fabrication of a graphene oxide/titania nanocomposite and its electro-responsive characteristics.Chem Commun(Camb),2011,47(45):12286-12288.
[2]Rothenberg ML,Carbone DR,Johnson DH.Improving the evaluation of new cancer treatments:challenges and opportunities.Nat Rev Cancer,2003,3(4):303-309.
[3]Haley B,Frenkel E.Nanoparticles for drug delivery in cancer treatment.Urol Oncol,2008,26(1):57-64.
[4]Kim S,Shi YZ,Kim JY,et al.Overcoming the barriers in micellar drug delivery:loading efficiency,in vivo stability,and micelle-cell interaction.Expert Opin Drug Deliv,2010,7(1):49-62.
[5]Sercombe L,Veerati T,Moheimani F,et al.Advances and challenges of liposome assisted drug delivery.Front Pharmacol,2015,6:286.
[6]Li JC,Rao JH,Pu KY.Recent progress on semiconducting polymer nanoparticles for molecular imaging and cancer phototherapy.Biomaterials,2018,155:217-235.
[7]Castillo RR,Colilla M,Vallet-RegíM.Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer.Expert Opin Drug Deliv,2017,14(2):229-243.
[8]Pattni BS,Chupin VV,Torchilin VP.New developments in liposomal drug delivery.Chem Rev,2015,115(19):10938-10966.
[9]Wang X,Wang Y,Chen ZG,et al.Advances of cancer therapy by nanotechnology.Cancer Res Treat,2009,41(1):1-11.
[10]Karve S,Bandekar A,Ali MR,et al.The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity.Biomaterials,2010,31(15):4409-4416.
[11]Monteiro LOF,Malachias?,Pound-Lana G,et al.Paclitaxel-loaded pH-sensitive liposome:new insights on structural and physicochemical characterization.Langmuir,2018,34(20):5728-5737.
[12]Liu J,Huang Y,Kumar A,et al.pH-Sensitive nano-systems for drug delivery in cancer therapy.Biotechnol Adv,2014,32(4):693-710.
[13]Sun TM,Wang YC,Wang F,et al.Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds.Biomaterials,2014,35(2):836-845.
[14]Jain NK,Tare MS,Mishra V,et al.The development,characterization and in vivo anti-ovarian cancer activity of poly(propylene imine)(PPI)-antibody conjugates containing encapsulated paclitaxel.Nanomed-Nanotechnol,2015,11(1):207-218.
[15]SzabóI,Manea M,Orbán E,et al.Development of an oxime bond containing daunorubicin-gonadotropin-releasing hormone-III conjugate as a potential anticancer drug.Bioconjug Chem,2009,20(4):656-665.
[16]Jin Y,Song L,Su Y,et al.Oxime lnkage:a robust tool for the design of pH-sensitive polymeric drug carriers.Biomacromolecules,2011,12(10):3460-3468.
[17]Deng H,Liu J,Zhao X,et al.PEG-b-PCL copolymer micelles with the ability of pH-controlled negative-to-positive charge reversal for intracellular delivery of doxorubicin.Biomacromolecules,2014,15(11):4281-4292.
[18]Zloh M,Dinand E,Brocchini S.Aconityl-derived polymers for biomedical applications.Modeling study of cis-trans isomerisation.Theor Chem Acc,2003,109(4):206-212.
[19]Gillies ER,Goodwin AP,Fréchet JM.Acetals as pH-sensitive linkages for drug delivery.Bioconjug Chem,2004,15(6):1254-1263.
[20]Heffernan MJ,Murthy N.Polyketal nanoparticles:a new pH-sensitive biodegradable drug delivery vehicle.Bioconjug Chem,2005,16(6):1340-1342.
[21]Shin JH,Shum P,Grey J,et al.Acid-labile m PEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity:synthesis and structural effects on hydrolysis rates,DOPE liposome release performance,and pharmacokinetics.Mol Pharm,2012,9(11):3266-3276.
[22]Masson C,Garinot M,Mignet N,et al.pH-sensitive PEG lipids containing orthoester linkers:new potential tools for nonviral gene delivery.J Control Release,2004,99(3):423-434.
[23]Farkhani SM,Valizadeh A,Karami H,et al.Cell penetrating peptides:efficient vectors for delivery of nanoparticles,nanocarriers,therapeutic and diagnostic molecules.Peptides,2014,57:78-94.
[24]Jiang T,Zhang Z,Zhang Y,et al.Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery.Biomaterials,2012,33(36):9246-9258.
[25]Ko r en E,Ap te A,Jani A,et al.Mul ti func tio nal PEG yla ted2C5-immunoliposomes containing pH-sensitive bonds and TATpeptide for enhanced tumor cell internalization and cytotoxicity.J Control Release,2012,160(2):264-273.
[26]Zhang L,Wang Y,Yang Y,et al.High tumor penetration of paclitaxel loaded pH sensitive cleavable liposomes by depletion of tumor collagen I in breast cancer.ACS Appl Mater Interfaces,2015,7(18):9691-9701.
[27]Xiang B,Jia XL,Qi JL,et al.Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptidemodified liposomal system.Int J Nanomedicine,2017,12:2385-2405.
[28]Oude Blenke E,Sleszynska M,Evers MJ,et al.Strategies for the activation and release of the membranolytic peptide melittin from liposomes using endosomal pH as a trigger.Bioconjug Chem,2017,28(2):574-582.
[29]Huang Z,Guo X,Li W,et al.Acid-triggered transformation of diortho ester phosphocholine liposome.J Am Chem Soc,2006,128(1):60-61.
[30]Guo X,MacKay JA,Szoka FC Jr.Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid.Biophys J,2003,84(3):1784-1795.
[31]Kanamala M,Palmer BD,Ghandehari H,et al.PEG-benzaldehyde-hydrazone-lipid based PEG-sheddable p H-sensitive liposomes:abilities for endosomal escape and long circulation.Pharm Res,2018,35(8):154.
[32]Nie Y,Günther M,Gu Z,et al.Pyridylhydrazone-based PEGylation for pH-reversible lipopolyplex shielding.Biomaterials,2011,32(3):858-869.
[33]Shin J,Shum P,Thompson DH.Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids.J Control Release,2003,91(1-2):187-200.
[34]Kim HK,Thompson DH,Jang HS,et al.pH-responsive biodegradable assemblies containing tunable phenyl-substituted vinyl ethers for use as efficient gene delivery vehicles.ACS Appl Mater Interfaces,2013,5(12):5648-5658.
[35]Scomparin A,Florindo HF,Tiram G,et al.Two-step polymer-and liposome-enzyme prodrug therapies for cancer:PDEPT and PELTconcepts and future perspectives.Adv Drug Deliver Rev,2017,118:52-64.
[36]Luo Z,Cai K,Hu Y,et al.Mesoporous silica nanoparticles end-capped with collagen:redox-responsive nanoreservoirs for targeted drug delivery.Angew Chem Int Ed Engl,2011,50(3):640-643.
[37]Berndt I,Popescu C,Wortmann FJ,et al.Mechanics versus thermodynamics:swelling in multiple-temperature-sensitive core-shell microgels.Angew Chem Int Ed Engl,2006,45(7):1081-1085.
[38]Yan F,Li L,Deng Z,et al.Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers.J Control Release,2013,166(3):246-255.
[39]Ercole F,Davis TP,Evans RA.Photo-responsive systems and biomaterials:photochromic polymers,light-triggered self-assembly,surface modification,fluorescence modulation and beyond.Polym Chem,2010,1:37-54.
[40]Zhang CY,Wu D,Lu LJ,et al.Multifunctional hybrid liposome as a theranostic platform for magnetic resonance imaging guided photothermal therapy.ACS Biomater Sci Eng,2018,4(7):2597-2605.
[41]Zhang WL,Choi HJ.Fast and facile fabrication of a graphene oxide/titania nanocomposite and its electro-responsive characteristics.Chem Commun(Camb),2011,47(45):12286-12288.